The Science Of Age Defiance



The Science of Age-Defiance


Don’t just age with grace. Age better with advanced science.

Explore our range of products that are based on groundbreaking research into replenishing the Nitric Oxide (NO) that’s lost as we age.

Featured on The Human Upgrade with Dave Asprey

No Risk - 60-day Money Back Guarantee

Made in America

Nitric Oxide Products Backed by 20+ Years of Science

Our products are clinically proven to enhance Nitric Oxide in the body so that you feel the effects of aging less.

You loved us – too much!

With the increase in demand from our incredible customers, we are working hard to get the products in stock for you. We all understand the importance of Nitric Oxide for your daily health routine. Pre-order now to secure your order and allow us to ship to you as soon as the product is back in stock.
We are automatically adding a 10% discount with free US shipping to your order. Please note that any coupon you add will replace this automatic 10% off coupon.
Thank you for your support and for trusting us to be your favorite Nitric Oxide solution!

Changing the Way We Age for the Better

We’re all going to age. It’s just a matter of how you’re going to do it. We believe in aging on your
own terms, and for us that means maintaining a high quality of health all around. One of the
common factors for making that happen is Nitric Oxide.

Properly formulated Nitric Oxide products have the ability to:

  • Improve Nitric Oxide production
  • Enhance the delivery of oxygen and nutrients to cells
  • Provide antioxidant support
  • Reduce wrinkles and fine lines
  • Correct dark spots and even skin tone
  • Improve skin texture and moisture
  • Increase elasticity
  • Create tighter, smoother skin
  • Repair damaged skin
  • Increase energy levels
  • Improve sexual function
  • Support cognitive function and memory
  • Support cardiovascular health
  • Promote normal heart function
  • Aid in healthy blood circulation and blood pressure
  • Create healthy blood flow to the brain and other organs
  From the surface of your skin to the arteries underneath, Nitric Oxide is the factor that can make aging better.

Backed by 20 Years of Scientific Research and Peer-Reviewed Published Clinical Studies. View the clinical studies click here.


A recently published study in the Journal of Surgery by Gregory Chernoff, M.D., F.R.C.S.(C) demonstrated the successful use of N1O1 a topical Nitric Oxide serum on aging skin, acne, wound healing, and scar therapy. View the study here. 


Dr. Bryan, CEO & Founder, has been a pioneering figure in the field of nitric oxide research for over 20 years. In addition to creating N1O1 by Pneuma Nitric Oxide, he is the holder of more than a dozen issued U.S. and International patents for breakthrough techniques that have revolutionized human physiology and disease management. The revolutionary N1O1 Nitric Oxide Activating Anti-Aging Serum is his next breakthrough patent.


N1o1 Anti-aging serum

the Aesthetic guide featuring n1o1 serum

“Early intervention with skincare keeps you looking younger, longer, sooner and often without expensive procedures.” – Dr. Chernoff


What Causes Clogged Pores?

What Causes Clogged Pores? Do you get breakouts that don’t ever seem to go away? Have you tried everything and for some reason you can’t get rid of a few blackheads or whiteheads? Clogged pores might be the reason your skin hasn’t been able to...

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Daily Beauty Habits That Are Aging Your Eyes

Daily Beauty Habits That Are Aging Your Eyes

Sometimes there just aren’t enough hours in the day—add in genetics, gravity, stress, and years of squinting and smiling, you get crow's feet, dark circles, and under-eye puffiness-factors that instantly add years to your appearance. But these aren’t the only things...

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What real n1o1 users are Saying...

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The N1o1 Money-Back Guarantee

There's nothing to lose, except Your wrinkles.

Developed and manufactured in the USA by Pneuma Nitric Oxide LLC.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat,
cure, or prevent any disease

© 2024 Pneuma Nitric Oxide LLC

By purchasing Pneuma Nitric Oxide LLC products, the buyer agrees that the products are for personal use or use by the purchaser only and may not be resold, redistributed, or exported. Unauthorized resale or distribution may lead to legal action, including but not limited to injunctions, seizure of products, and damages.

Pneuma Nitric Oxide LLC enforces its rights against unauthorized resale activities vigorously and will take legal action to protect its intellectual property to the fullest extent of the law.


All company brand names, and logos of Pneuma Nitric Oxide LLC are trademarks or registered trademarks of Pneuma Nitric Oxide LLC or its affiliates. Unauthorized use is strictly prohibited.

Pneuma Nitric Oxide

Mailing Address

Pneuma Nitric Oxide, LLC
2407 S. Congress
Suite E 134
Austin, TX. 78704