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Unlock radiant, youthful skin with our expertly crafted skincare solutions for every skin type and concern.

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Skin Care

Revitalize your skin with Pneuma Nitric Oxide’s Skin Care line, expertly crafted by Dr. Nathan S. Bryan. Our products, enriched with powerful nitric oxide, are designed to nourish, repair, and protect your skin, promoting a clear, youthful, and vibrant complexion. Dive into our scientifically formulated range for ultimate skin health and beauty. Shop now and witness the transformation!

This face cream is amazing! It’s lightweight, non-greasy, and perfect for my sensitive skin. My complexion has never looked better.

Over 1,600 Five Star Reviews

Best Skin Cream

Your Skincare Solution

A Symphony of Skincare

Hydrates Deeply Protects Skin Boosts Collagen

Pneuma Nitric Oxide’s skincare system is a harmonious blend of scientifically crafted products, each playing a unique role, yet all working together to achieve complete skin revitalization.

N1O1 Skin Care
Nitric Oxide Age-Defiance Gel Cleanser by Dr. Nathan S. Bryan

EXFOLIATING GEL CLEANSER

Benefit: Gently cleanses and primes the skin, preparing it for the serum

Impact: Ensures optimal absorption of nitric oxide, enhancing the serum’s effects.

NITRIC OXIDE SERUM

Benefit: Replenishes nitric oxide, smoothens wrinkles, and enhances complexion.

Impact: The heart of our system, setting the stage for transformation.

Nitric Oxide Age-Defiance Eye Cream by Dr. Nathan Bryan

AGE-DEFIANCE EYE CREAM

Benefit: Locks in hydration, nourishes, and protects the skin

Impact: Complements the serum by sealing in the benefits and maintaining skin’s radiant glow.

Age-Defiance Face Cream Skincare Lasting Radiance, Lasting Value

AGE-DEFIANCE EYE CREAM

Benefit:Targets signs of aging, firms, and boosts skin elasticity.

Impact: Works in harmony with the serum to provide a comprehensive anti-aging solution.

See the Transformation: Before & After

Allison
Age: 25
Nick
Age: 28
Nancy
Age: 49
Before After
Before After
Before After
Allison
Age: 25
Before After
Nick
Age: 28
Before After
Nancy
Age: 49
Before After

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Beauty Products For Anti-Aging

1,000,000+ customers worldwide!

Don't just take our word for it

Over 1,600 five star reviews
4.9 average
776 reviews
Serum Bottle Transparent

LOVE the combination of this serum! It tightened my face and helped keep my face looking its best. I truly loved it and it’s worth every penny! I am 45+ and have become very purposeful with every serum and face cream I use these days. This was never oily, it never broke out my skin, and the results have been obvious! Thrilled with the results.

Berri Gormley

Age-Defiance Serum shop now

Has amazing action on some long standing dried non-healing skin lesions. Also pale dry, corpse-like complexion looks alive again. Hoping with long-term use I’ll see more uniformity in color and tone. Moisturizes well but a follow up with another moisturizing product enhances it. Scent is somewhat reminiscent of when parched earth is damped by light rainfall, so not your typical fruitiness of common moisturizers.

Antoinette Simmons

Age-Defiance Face Cream shop now

I like the texture, smell is very neutral, which i like, and it is filled completely to the top so be careful when taking off the lid, be ready to apply some. I have tried other N1O1 products and this is a great compliment and worth the price. after applying i could feel a slight tingling sensation, but seems to be working great to hydrate the area around my eyes. I am grateful there is a N1O1 store on amazon.

Martin W.

Age-Defiance Eye Cream shop now

Don't just take our word for it

Over 1,600 five star reviews
4.9 average
776 reviews
Serum Bottle Transparent

LOVE the combination of this serum! It tightened my face and helped keep my face looking its best. I truly loved it and it’s worth every penny! I am 45+ and have become very purposeful with every serum and face cream I use these days. This was never oily, it never broke out my skin, and the results have been obvious! Thrilled with the results.

Berri Gormley

Age-Defiance Serum shop now

Has amazing action on some long standing dried non-healing skin lesions. Also pale dry, corpse-like complexion looks alive again. Hoping with long-term use I’ll see more uniformity in color and tone. Moisturizes well but a follow up with another moisturizing product enhances it. Scent is somewhat reminiscent of when parched earth is damped by light rainfall, so not your typical fruitiness of common moisturizers.

Antoinette Simmons

Age-Defiance Face Cream shop now

I like the texture, smell is very neutral, which i like, and it is filled completely to the top so be careful when taking off the lid, be ready to apply some. I have tried other N1O1 products and this is a great compliment and worth the price. after applying i could feel a slight tingling sensation, but seems to be working great to hydrate the area around my eyes. I am grateful there is a N1O1 store on amazon.

Martin W.

Age-Defiance Eye Cream shop now

Don't just take our word for it

Over 1,600 five star reviews

4.9 average
776 reviews

Serum Bottle Transparent

LOVE the combination of this serum! It tightened my face and helped keep my face looking its best. I truly loved it and it’s worth every penny! I am 45+ and have become very purposeful with every serum and face cream I use these days. This was never oily, it never broke out my skin, and the results have been obvious! Thrilled with the results.

Berri Gormley

Age-Defiance Serum shop now

Has amazing action on some long standing dried non-healing skin lesions. Also pale dry, corpse-like complexion looks alive again. Hoping with long-term use I’ll see more uniformity in color and tone. Moisturizes well but a follow up with another moisturizing product enhances it. Scent is somewhat reminiscent of when parched earth is damped by light rainfall, so not your typical fruitiness of common moisturizers.

Antoinette Simmons

Age-Defiance Face Cream shop now

I like the texture, smell is very neutral, which i like, and it is filled completely to the top so be careful when taking off the lid, be ready to apply some. I have tried other N1O1 products and this is a great compliment and worth the price. after applying i could feel a slight tingling sensation, but seems to be working great to hydrate the area around my eyes. I am grateful there is a N1O1 store on amazon.

Martin W.

Age-Defiance Eye Cream shop now

Pure Ingredients, Pure Results

We prioritize high-quality ingredients to ensure you look and feel your best. No shortcuts, no compromises just effective, reliable skincare.

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