The N1o1 story

About N1o1

Nitric oxide skincare and supplements, with a philosophy of honor, integrity, transparency and accountability.

Our Story

Decades of Nitric Oxide Research. One Mission: Redefine Healthy Aging.

Built on more than 30 years of pioneering nitric oxide research by Dr. Nathan S. Bryan, N1o1 brings science-backed innovation to everyday wellness.

From our proprietary dual-chamber Nitric Oxide Activating Serum to our advanced nutritional supplements, oral care, and age-defying skincare, every product is designed to support your body's nitric oxide needs as you age.

One molecule. Complete Inside & Out Wellness.

N1o1 Inside & Out Glow Collection full product line

Our Philosophy

We promise to operate with honor, integrity, transparency, and accountability in all of our dealings with our customers. This philosophy guides all our business decisions.

Our Vision

To stay true to the science of NO and harness the potential it has to change the landscape of the beauty and cosmetic industry. We want to change the world and leave a lasting legacy on humanity.

Nathan S. Bryan, Ph.D.

Founder and CEO

Dr. Bryan’s work focuses on molecular medicine and nitric oxide biochemistry.

He completed his B.S. in Biochemistry from The University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine. He then completed his post-doctoral training at Boston University School of Medicine in the Whitaker Cardiovascular Institute. In 2006, Dr. Bryan was recruited to join the faculty at The University of Texas Health Science Center by Dr. Ferid Murad, a Nobel Prize winner known for his work with nitric oxide.

Read Dr. Bryan’s biography and bibliography

Susan K. Shaffer

Co-founder & President

Susan Shaffer has over 30 years of corporate experience and a vast network of industry associations. Her unique brand of strategic business acumen, relationship, and management skills has helped high-profile companies like Lancome, Dell, 3COMM, and HumanN.

Ms. Shaffer worked with Dr. Bryan at a company dedicated to using nitric oxide in dietary supplementation. Her work at N1o1 focuses on product innovation.

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I started these a month ago after my sister sent me a bottle. I have MS and have had many issues of pressure sores due to being paralyzed. My sores have healed very fast and hoping they continue. My husband also takes them as he has cancer and being on chemo; he has had no bad reaction to his treatments. These are a winner at our home.

I really appreciate the deep research backed behind this product (I also have his book. Still need to read). I've been a consistent customer for WELL over a year now but I may have to stop. Things are getting so expensive that I'm having to find a more affordable product. Also, there are SO MANY 'Other Ingredients' that I didn't realize until recently (not sure how I missed this). There's probably a reason for that. I don't like the citric acid, natural flavors, stevia AND monk fruit (rather than just one), ,,, I don't know. I've lost trust with the American food, preservative, and supplementation systems. I've struggled with health issues and wonder how much of it has to do with these 'fillers' that people say are 'reasonably safe'.

I think this tooth paste is excellent and my teeth feels happily cleaned I’m in my eighties and have pain in my hands and it’s so difficult to squeeze maybe the tube could be made softer for us older folks 😊

I have been using the N1o1 and I can tell the difference in my energy level. I can also tell that my cholesterol numbers are lower.

I've been giving this to my father who has emphasema and an oxygen saturation count of 89 after having one lozenger he's oxygen saturation goes up to 98.to 99 for about 6 to 8 hours before needing another longer
It has helped improve his breathing is not short of breath or wheezing while having lozenger
I take them myself being a smoker I noticed I'm shorter breath when exercising if I have one before exercising I'm not as short of breath and dizzy at the end of exercises
My father's lung specialist Brian Jarvis thought there are waste of time until he seen the results on his pulse oximeter and the fact that my father was not sure of breath he recommended that I keep giving him to my father and he was gonna do some more research to see about recommending some to his other patients

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About N1o1

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Nathan S. Bryan, Ph.D.

Susan K. Shaffer

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Nathan S. Bryan, Ph.D.

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