The Science Of Age Defiance



The Science of Age-Defiance

Confidence Begins Here.

Visibly Smoother Skin. Clinically Proven.

Explore Our Range Of Age-Defiance Products


• Reduces Wrinkles & Fine Lines

• Corrects Dark Spots & Evens Skin Tone

• Improves Skin Texture & Clarity

• Increases Elasticity & Restores Moisture

• Creates Tighter, Smoother Skin

• Repairs Damaged Skin


Backed by 20 Years of Scientific Research and Peer-Reviewed Published Clinical Studies. View the clinical studies click here.


A recently published study in the Journal of Surgery by Gregory Chernoff, M.D., F.R.C.S.(C) demonstrated the successful use of N1O1 a topical Nitric Oxide serum on aging skin, acne, wound healing, and scar therapy. View the study here. 


Dr. Bryan, CEO & Founder, has been a pioneering figure in the field of nitric oxide research for over 20 years. In addition to creating N1O1 by Pneuma Nitric Oxide, he is the holder of more than a dozen issued U.S. and International patents for breakthrough techniques that have revolutionized human physiology and disease management. The revolutionary N1O1 Nitric Oxide Activating Anti-Aging Serum is his next breakthrough patent.


N1o1 Anti-aging serum

the Aesthetic guide featuring n1o1 serum

“Early intervention with skincare keeps you looking younger, longer, sooner and often without expensive procedures.” – Dr. Chernoff


What Causes Clogged Pores?

What Causes Clogged Pores?

Do you get breakouts that don’t ever seem to go away? Have you tried everything and for some reason you can’t get rid of a few blackheads or whiteheads? Clogged pores might be the reason your skin hasn’t been able to breathe. But what are the pores clogged with? And...

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Daily Beauty Habits That Are Aging Your Eyes

Daily Beauty Habits That Are Aging Your Eyes

Sometimes there just aren’t enough hours in the day—add in genetics, gravity, stress, and years of squinting and smiling, you get crow's feet, dark circles, and under-eye puffiness-factors that instantly add years to your appearance. But these aren’t the only things...

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What real n1o1 users are Saying...

Michelle W., 49

My skin was dry, aging, lifeless, kind of dull. I needed to rejuvenate my skin but needed something simple, no deep regimens. My age spots diminished, so did the wrinkles around my mouth and smile lines, my skin plumped up. I felt it was working the minute I put it on. I felt a little bit of heat, which dissipated, and I felt it plumping my skin. My pores diminished, my makeup goes on smoother, my skin is brighter, rejuvenated, less fine lines, and wrinkles.

Cheyenne A., 19

I’m ecstatic. I can show everyone my face. Look at me now. I’m a new person.

Teneisha A.

She struggled in high school. We tried everything and went to a few different doctors but none of it worked. A friend reached out about N1o1. We tried everything else, why not. In the first week, I noticed a difference; her skin got tighter, the pores got smaller, and the oiliness dried up. As she continued to use it, the better it got. The blemishes were lightening up and the clusters of blemishes got smaller.

Suzanne S., 57

My skin overall has a better texture and a healthier glow. I have never been very consistent with my beauty routine due to my busy schedule, but the results from Pneuma Nitric Oxide have inspired me to use the product regularly. I don’t want to stop using this product. It is the one beauty product I won’t skip.

Gia A., 45

I am using Pneuma currently, so that's how I know about it.  It is simply the most transformative skincare product I've ever used!

Lora A, Dragon Tree Therapeutic, LLC

I'm a FMR esthetician and as such come across countless skincare products. But a product, a compound that actually primes your skin? Now that's genius! Pneuma serum is truly a game-changer. A must-have weapon in the war on aging skin.

Robert M., 49

Being a guy, I don't like using products that have a strong fragrance. Pneuma has very little. I get shaving burn daily. Pneuma helped soothe my irritated skin and gave me an airbrushed complexion. I'd recommend it to any guy who just wants to look better

Laurie H., Owner & Co-Director, Facial Rejuvenation Center

Pneuma Nitric Oxide makes aging less daunting because now when I look in the mirror...I see radiance

The N1o1 Money-Back Guarantee

There's nothing to lose, except Your wrinkles.

Pneuma Nitric Oxide

Mailing Address

Pneuma Nitric Oxide, LLC

2407 S. Congress

Suite E 134

Austin, TX. 78704


(877) 476-3862


Developed and manufactured in the USA by Pneuma Nitric Oxide LLC.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat,
cure, or prevent any disease

© 2023 Pneuma Nitric Oxide LLC
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