Instagram Linkedin Facebook Tiktok

Biggest discount of the year! Use discount code LOVE for 20% off + Free Shipping

User

FAQ

FAQ

Product Questions

N1o1 Nitric Oxide Lozenges

N1o1 Lozenges contain Magnesium Ascorbate and Sodium Nitrite, which combine to stimulate natural Nitric Oxide production in your body. This helps enhance blood flow, reduce fatigue, and support heart and brain health.

Anyone looking to improve circulation, boost energy, enhance endurance, or support cardiovascular health can benefit. It’s especially helpful for active individuals, older adults, and those looking to optimize overall wellness.

Simply dissolve one lozenge in your mouth daily for best results. Taking it in the morning or before physical activity can help maximize its effects. We suggest taking on an empty stomach for optimal results. But if you forget – take the lozenge anyway! Nitric oxide gas will still be created and you will still receive the benefit.

Yes, N1o1 Nitric Oxide Lozenges are safe for daily use. They are made with high-quality, clinically backed research and are free from harmful additives, providing a natural way to support your wellness.

Boosting nitric oxide promotes improved blood flow, supports heart health, enhances stamina, and facilitates better nutrient delivery throughout the body. N1o1 Lozenges help you feel more energized while supporting your body’s natural processes.  Nitric oxide also helps reduce inflammation and oxidative stress.

Each bottle contains 60 lozenges, providing a full 30-day supply when taken twice daily.
Increased blood flow and increased oxygen flow may aid in better sleep.
Yes, Cialis and other similar products need oxygen to work. Our Nitric Oxide lozenges can increase blood flow, and oxygen delivery, which enables those products to work more effectively.

While N1o1 Lozenges are safe for most people, always check with your healthcare provider before combining them with other medications or supplements.

For those with high saliva acidity, we recommend swishing a mixture of baking soda and 2-3 ounces of water in your mouth for 30-60 seconds before taking the lozenge. This simple step helps alkalize and balance pH levels, reducing sensitivity to Vitamin C and enhancing your experience.

N1o1 Lozenges are made with carefully selected ingredients and are generally well tolerated. However, if you have low blood pressure or are taking medication, consult your doctor before use.

N1o1 Nitric Oxide Lozenges are formulated based on extensive scientific research into nitric oxide’s health benefits. The ingredients in N1o1 are clinically validated to enhance nitric oxide production and promote vitality.

Our Nitric Oxide Lozenges provide a sustained release of nitric oxide – which can provide a long-term restorative benefit. This can result in systemic support with continued use.

Our N.O. Beetz powder provides an episodic delivery of nitric oxide to the body, which once it is burned through the body, is expelled and gone from your system. This episodic delivery is great for pre-workout use, or any time you need a boost of energy and clarity.

One product does not preclude the other…you’ll want to take the lozenges twice daily as an ongoing remedy for decreased nitric oxide production, and the beet powder for a more instant delivery of nitric oxide.

A very small amount of Maltodextrin is used in the formulation of our Lozenges and is necessary to aid in the success of our product.

Yes, small dogs can take 1/2 lozenge and larger dogs can take a whole lozenge.

N.O. Beetz Nitric Oxide Supplement

How does N.O. Beetz work?

N.O. Beetz harnesses the power of specially fermented beetroot powder to naturally elevate your body’s nitric oxide levels. By improving circulation, it promotes better energy and overall wellness—offering a gentle, sustained boost without the jitters or crash of stimulant-packed energy drinks.

Yes, N.O. Beetz is made from organic, non-GMO beetroot and is safe for daily use. It’s free from stimulants and artificial additives, making it a natural way to support your health.
Nitric oxide improves blood flow, supports cardiovascular health, enhances stamina, and aids nutrient delivery throughout the body. N.O. Beetz helps you feel energized and supports your body’s natural functions.

Adults can consume one packet of N.O. Beetz daily to help naturally boost Nitric Oxide production and feel more energized throughout the day. Mix the contents of one packet with 2-3 ounces of water, dissolve fully, and drink immediately as a shot. For best results, take it immediately before exercising or whenever an energy boost is needed.

N.O. Beetz is oxalate-free and uses an advanced delivery system to provide an exogenous source of nitric oxide without the typical beet taste, color, or mess. It is clean, portable, and free from stimulants, making it a convenient and effective option for boosting energy and supporting heart health. If your body has lost the ability to naturally produce nitric oxide, N.O. Beetz provides it for you.

N.O. Beetz is formulated based on scientific research highlighting the health benefits of nitric oxide. Dr. Bryan has made many seminal discoveries in the nitric oxide field and has created a solid dose form of nitric oxide gas.

Yes, N.O. Beetz can be combined with other supplements, such as N1o1 Nitric Oxide Lozenges. However, it’s recommended to take them at different times as part of a well-rounded health routine. If you have any specific health conditions or concerns, consult your healthcare provider before use. Allow at least 4 hours between dosing N.O. Beetz and N1o1 lozenges.

Users should only consume one packet no sooner than every 4 hours to avoid a potential unsafe drop in blood pressure. It is recommended to consult your healthcare provider before use if you are pregnant, nursing, taking medications, or have a medical condition.

Our Nitric Oxide Lozenges provide a sustained release of nitric oxide – which can provide a long-term restorative benefit. This can result in systemic support with continued use.

Our N.O. Beetz powder provides an episodic delivery of nitric oxide to the body, which once it is burned through the body, is expelled and gone from your system. This episodic delivery is great for pre-workout use, or any time you need a boost of energy and clarity.

One product does not preclude the other…you’ll want to take the lozenges twice daily as an ongoing remedy for decreased nitric oxide production, and the beet powder for a more instant delivery of nitric oxide.

No – our N.O. Beetz product has no measurable oxalates. Both beet greens and beetroot have high levels of oxalates, which have been linked to kidney stones. Our N.O. Beetz product has been formulated to remove the color, smell, and taste of beets – so perfectly safe for anyone who may have experienced issues with kidney stones in the past.

Yes, you can sprinkle the Beetz powder on their food.

CardioSmile Nitric Oxide Boosting Toothpaste

What is Nitric Oxide?
Nitric Oxide (NO) is a molecule that helps relax and widen blood vessels, improving circulation, oxygen delivery, and overall cardiovascular health. It also supports energy levels, endurance, cognitive, oral, and sexual function.

Nitric oxide plays a crucial role in maintaining good oral health. It helps to improve blood flow and supports the body’s natural defenses against harmful bacteria. Additionally, it aids in saliva production, which is essential for keeping the mouth clean and neutralizing acids that can erode tooth enamel. Without enough nitric oxide, these functions can become compromised, leading to various oral health problems.

Brush thoroughly, at least twice a day, or as directed by a healthcare provider. Use desired amount on a toothbrush.

Many users report an immediate clean mouth feeling with fresh breath.  Within a couple of days, an improvement in the oral microbiome and normal salivary pH.  Many people also report an increased energy and better circulation within days. However, consistent use over a few weeks yields the best long-term benefits.

Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite Ψ Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulvaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate

📦 Free Shipping for Orders Over $300
🚚 Fast Delivery within 2-6 business days

N1o1 Age Defiance Serum

What makes the N1o1 Nitric Oxide Activating Serum different from other anti-aging serums?

This is the first and only serum in the world that generates nitric oxide directly on your skin’s surface. Its unique dual-chamber system activates upon use, delivering a fresh, potent dose every time to revitalize your skin’s appearance in a way no other product can.

Nitric oxide is a vital molecule that supports circulation. By improving localized microcirculation, it helps deliver oxygen and nutrients to skin cells, which in turn supports the look of healthy collagen, refines skin texture, and promotes a brighter, more even-toned complexion.

Our serum is the only product on the market that generates nitric oxide on the surface of the skin. There literally is no other product like this serum!

The brief pink flush and warming sensation you may feel is a visible sign that the serum is working. This indicates the generation of nitric oxide and an increase in local circulation, which is a normal and temporary effect that typically fades within a few minutes.

The N1o1 Nitric Oxide Activating Serum is formulated to be gentle and effective for all skin types, including sensitive, oily, dry, and combination skin. Its purpose is to restore healthy skin function, making it a universal tool for anyone seeking to address the visible signs of aging.

Use it twice daily, morning and night, on clean skin. Dispense one pump from each chamber, mix them in your palm, and apply a thin layer to your face and neck. A single bottle provides approximately 70 applications.

While many users notice an immediate glow, consistent use is key for long-term benefits. Most people report visible improvements in skin tone, texture, and the appearance of fine lines and wrinkles within the first 30 days of daily use.

Yes. Our serum contains 20% Vitamin C, so you won’t need a separate one. Apply N1o1 first on clean, dry skin, wait 1-2 minutes for it to fully absorb, and then you can layer other products like moisturizers or your nightly retinoid on top.

Yes, the N1o1 Nitric Oxide Activating Age-Defiance Serum is supported by multiple clinical studies that demonstrate its effectiveness in improving the appearance of skin tone, texture, reducing the visibility of fine lines and wrinkles, and boasts a 100% satisfaction rating among users in the clinical studies. Regular use in these studies led to noticeable cosmetic improvements for most participants.

We are committed to creating powerful skincare without compromise. The N1o1 serum is proudly vegan, cruelty-free, gluten-free, and non-GMO.

Store your serum in a cool, dark place to protect its potency, and be sure to use it before the expiration date on the package. We are confident you’ll love the results, which is why every purchase is backed by our 60-day money-back guarantee.

Nitric Oxide Age-Defiance Face Cream

How does nitric oxide improve the look of my skin?

Nitric oxide is a vital molecule that supports microcirculation. By applying it topically, our formula helps deliver oxygen and nutrients to your skin cells. This process, complemented by powerful antioxidants Vitamin C and E, helps refine skin texture, promote a brighter complexion, and restore a youthful glow.

Yes. The Nitric Oxide Age-Defiance Face Cream is formulated to be gentle yet effective for all skin types, including sensitive, oily, dry, and combination skin. Its primary goal is to help restore healthy-looking skin function, making it a universal solution for anyone wanting to address the visible signs of aging.

For the best results, always apply the N1o1 Face Cream first on clean, dry skin. After applying, wait 1-2 minutes for it to fully absorb. You can then layer your other products, in the morning, or a retinoid product at night.

Many users experience an immediate, refreshed glow after their first application. However, consistent daily use is essential for long-term benefits. Most people report visible improvements in skin tone, texture, and the appearance of fine lines within the first 30 days.

The N1o1 Face Cream was formulated by Dr. Nathan S. Bryan and its ingredients are backed by multiple clinical studies demonstrating their cosmetic effectiveness.  We are also committed to clean beauty: the formula is vegan, cruelty-free, gluten-free, and non-GMO.

For the best results, start by cleansing with our Age-Defiance Gel Cleanser. Follow up with our Nitric Oxide Activating Age-Defiance Serum. Once the serum is fully absorbed, apply the N1o1 Face Cream and follow up with the Nitric Oxide Age-Defiance Eye Cream to treat the delicate under-eye area. This routine ensures that the benefits of each product are maximized for optimal skin health.

Nitric Oxide Age-Defiance Eye Cream

How does nitric oxide improve the look of my under-eye area?

Nitric oxide enhances microcirculation, delivering oxygen and nutrients to your skin cells. This process helps reduce puffiness, brighten dark circles, and smooth fine lines, leaving your eyes looking refreshed and youthful.

Yes. The Nitric Oxide Boosting Age-Defiance Eye Cream is gentle yet effective for all skin types, including sensitive, oily, dry, and combination skin.

Many users experience a refreshed appearance after the first application. With consistent use, most report visible improvements in dark circles, puffiness, and fine lines within 30 days.

Yes. Formulated by Dr. Nathan S. Bryan, this eye cream is backed by clinical studies and is vegan, cruelty-free, gluten-free, and non-GMO.

N1o1 Nitric Oxide Body & Mind Essentials

What’s happening in my body as I take the N1o1 Nitric Oxide Lozenge?

Timeline of Physiological Effects Induced by a N1o1 Nitric Oxide Lozenge

Discover what’s happening in your body when you use a N1o1 Nitric Oxide Lozenge, from its physiological effects to how it quietly supports your overall health—even if you can’t feel it.

  • 12 Seconds – Carotid arteries begin to dilate, increasing blood flow to the brain.
  • 1 Minute – Blood vessels dilate, enhancing circulation throughout the body.
  • 5 Minutes – Notice a 2.1% boost in exercise performance.
  • 10 Minutes – Carotid arteries dilate by 13%, leading to a 34% increase in blood flow to the brain and body.
  • 20 Minutes – For individuals with elevated blood pressure (130-139/80-89 mmHg), systolic and diastolic blood pressure drops by 5-6 mmHg.
  • 20-30 Minutes – Blood vessels become more flexible and compliant, improving vascular function by 20% and reducing arterial strain.
  • 60 Minutes – Elevated blood pressure drops further by 8-10 mmHg, with some cases seeing reductions of up to 50-60 mmHg for extremely high readings.
  • 4 Hours – Endothelial function improves by 15-25%, boosting natural nitric oxide production.
  • 2 Weeks – Blood flow regulation improves, enhancing mitochondrial function and exercise capacity.
  • 3 Weeks – Reduced oxidative stress and inflammation.
  • 1 Month – Blood pressure in pre-hypertension and hypertension patients decreases by 12 mmHg systolic and 6 mmHg diastolic, triglycerides drop by 27%, and cardiovascular health improves.
  • 6 Months – Existing arterial plaque stabilizes and begins to regress by 11%; endothelial function normalizes.
  • 9 Months – Kidney function improves, protein excretion decreases, and cardiac function strengthens, including reduced cardiac hypertrophy.
  • 12 Months – Arterial health improves, telomeres stabilize, and antioxidant defenses combat post-meal oxidative stress and inflammation. Cognitive gains include better verbal memory and problem-solving skills.


Experience the comprehensive benefits of N1o1 Nitric Oxide Lozenges and transform your cardiovascular health at every stage.

Timeline of Benefits with N.O. Beetz

Discover how N.O. Beetz works to support your health step by step:

  • Within Minutes: Blood vessels begin to dilate, improving circulation and oxygen delivery.
  • Within Hours: Enhanced nitric oxide levels lead to better energy, stamina, and focus.
  • Within Weeks: Consistent use supports cardiovascular health, reduced oxidative stress, and improved endurance.
  • Within Months: Long-term benefits include stabilized blood pressure, reduced arterial plaque, more mitochondria per cell producing more energy more efficiently and improved overall vitality

Experience the Power of N.O. Beetz
Transform your health and performance with N.O. Beetz, the natural, science-backed solution for boosting nitric oxide levels.

CardioSmile is a first-of-its-kind toothpaste, designed to actively support your body’s nitric oxide ecosystem, beyond just cleaning teeth.

What makes it different:

  • Nitric oxide focus: The world’s first toothpaste supporting nitric oxide production and a healthy oral microbiome, linking oral care to whole-body circulation and cardiovascular wellness.
  • Fluoride free remineralization: Uses hydroxyapatite to strengthen and rebuild enamel, gentle on teeth and gums.
  • Oral microbiome support: Nurtures beneficial bacteria, avoids harsh antiseptics that suppress nitric oxide pathways, and maintains healthy saliva pH.
  • Sensitivity & tartar control: Potassium nitrate reduces sensitivity; zinc citrate, hydrated silica, and calcium carbonate control tartar and polish without aggressive abrasives.
  • Clean essential oils: Peppermint, spearmint, wintergreen, tea tree, and cinnamon provide natural antimicrobial breath freshening, free from chemical aftertaste.
  • Doctor-developed credibility: Created by leading nitric oxide researcher, Dr. Nathan S. Bryan, aligning with N1o1’s science-backed approach.


CardioSmile redefines toothpaste as a daily nitric oxide routine, supporting gum circulation, enamel health, fresh breath, and a resilient oral microbiome—all while being fluoride and harsh antiseptic-free.

N1o1 Nitric Oxide Activating Age-Defying Skincare Serum stands out for several key reasons:

  • First and only nitric oxide–generating serum: Unlike conventional serums, it actively generates nitric oxide on the skin’s surface. This addresses aging at a cellular level by improving oxygen and nutrient delivery to skin cells, boosting collagen, hydration, and healthy metabolism.
  • Dual‑chamber activation you can see: The two-part system mixes on application, visibly activating in seconds. A brief pink flush indicates increased nitric oxide activity, a visible sign of activation.
  • Clinically backed outcomes: Multiple clinical studies support improvements in wrinkles, pore size, skin tone, texture, clarity, and dark spots with regular use.
  • Synergy with Vitamin C and antioxidants: It combines nitric oxide activation with 20% Vitamin C and Vitamin E, enhancing brightening, collagen support, and free‑radical defense for comprehensive results.
  • Simple, high‑impact routine: Each bottle provides up to ~70 applications. Apply one pump from each chamber, twice daily on clean skin, and allow 1–2 minutes to absorb. This makes clinical‑grade results achievable with minimal effort.
  • Science led by a nitric oxide pioneer: Developed by Dr. Nathan S. Bryan, a leading authority in nitric oxide biochemistry, bringing two decades of research to daily skincare.

Bottom line: This serum doesn’t just layer antioxidants; it restores nitric oxide at the skin surface to re‑energize cellular function, helping skin look and act younger.

Many users feel an immediate sense of refreshment from the toothpaste and an energy lift from the lozenges and N.O. Beetz (it’s best to space these 4 hours apart). With consistent daily use of the Age-Defiance Serum, visible improvements in skin tone, texture, and the appearance of fine lines are often reported within 30 days.

Morning: Start by brushing with CardioSmile Toothpaste. Then, apply the Age-Defiance Serum to clean skin. Use N.O. Beetz for sustained energy or a pre-workout boost.

Throughout the Day: Use a N1o1 Nitric Oxide Lozenge as needed for a quick vitality lift.

Evening: Brush with CardioSmile Toothpaste and apply the Age-Defiance Serum before bed.

Nitric Oxide Age-Defiance Skincare System

How does the Age-Defiance Gel Cleanser work, and what are the key benefits?

The gel cleanser is designed to gently remove dirt, oil, and makeup without stripping the skin. It removes impurities and preps the skin for optimal absorption of active ingredients. With its advanced formula, it supports overall skin health and vitality.

Key benefits include:

  • Oxygenating and exfoliating the skin.
  • Brightening and protecting against environmental aggressors.
  • Encouraging cell turnover for a youthful appearance.
  • Soothing and hydrating the skin with natural ingredients like Aloe Vera and Green Tea.

The Nitric Oxide Activating Serum boosts nitric oxide levels to improve circulation, stimulate collagen production, and deliver essential nutrients to the skin. With 20% Vitamin C, it targets wrinkles and skin damage for a radiant, youthful complexion.

Key benefits include:

  • Reduction of wrinkles and fine lines.
  • Improved skin tone, texture, and hydration.
  • Minimized pores and dark spots.
  • Enhanced collagen production and oxygenation of skin cells.
  • A brighter, more youthful complexion.

The Nitric Oxide Age-Defiance Eye Cream is formulated with peptides, hyaluronic acid, and other active ingredients to restore nitric oxide levels, improve hydration, and promote collagen production.

Key benefits include:

  • Reduction of fine lines, wrinkles, and crow’s feet.
  • Brightening of dark circles and reduction of puffiness.
  • Enhanced hydration and firmness around the eyes.
  • Improved skin tone and texture for a youthful appearance.

The Nitric Oxide Age-Defiance Face Cream penetrates deeply to restore skin health at a cellular level. Nitric oxide enhances circulation, peptides rejuvenate skin, and EGF stimulates collagen and elastin production, leaving your skin firm, radiant, and youthful.

Key benefits include:

  • Reduction of wrinkles, fine lines, and uneven skin tone.
  • Enhanced hydration and skin elasticity.
  • Improved skin texture and a radiant, youthful glow.

Stimulation of collagen and elastin production for firmer, rejuvenated skin.
Nitric oxide enhances circulation, peptides restore and rejuvenate, and EGF boosts collagen and elastin, leaving your skin firm, healthy, and youthful.

Yes, the Age-Defiance Skincare System is designed to work with all skin types, providing hydration, nourishment, and anti-aging benefits.

Our N1o1 Nitric Oxide Activating Age-Defiance Serum is scientifically formulated and clinically proven in 5 peer-reviewed published studies to deliver results inspired by a Nobel Prize-winning discovery.

For best results, use the cleanser, serum, eye cream, and face cream daily as part of your skincare routine. Follow the instructions on each product for optimal usage.

Nitric Oxide Anti-Aging Bundle

What is Nitric Oxide?

Nitric Oxide, a Nobel Prize-winning discovery, plays a vital role in promoting cardiovascular and skin health. We are all born with this remarkable molecule that helps relax and expand blood vessels, enhancing circulation, oxygen delivery, and nutrient absorption. By improving blood flow, it supports overall cardiovascular function while nourishing skin cells for healthier, more vibrant skin.

Nitric oxide is naturally present in our bodies from birth, but its production declines with age, contributing to visible signs of skin aging like wrinkles, dark spots, fine lines, and reduced skin elasticity. Restoring Nitric Oxide levels can directly address these issues and slow down the signs of aging.
  • Stimulates collagen production for firmer, smoother skin
  • Enhances oxygen and hydration delivery to skin cells
  • Improves overall skin tone, texture, and clarity
  • Reduces the appearance of wrinkles, dark spots, and fine lines

Backed by 20 years of research and proven in clinical studies, N1o1 Anti-Aging Serum replenishes Nitric Oxide levels in your skin. Its unique formula works immediately, helping you achieve youthful, radiant skin while addressing the root causes of aging.

The N1o1 Age-Defying Gel Cleanser helps by gently cleansing the skin using natural fruit, flower, and plant extracts. Its Alpha-Hydroxy Acid (AHA) blend promotes cell turnover and oxygenates skin cells, while Vitamin C and Green Tea provide antioxidant protection and brighten the complexion. Soothing ingredients like Aloe Vera, Algae Extract, and Kola Nut Extract calm and nourish the skin, leaving it refreshed and radiant. It pairs perfectly with the N1o1 anti-aging serum, face cream, and eye cream for enhanced results.

The time it takes to see results can vary depending on individual skin type and concerns. However, many users have reported visible improvements in their skin’s texture, tone, and overall appearance within a few weeks of consistent use. With continuous use, the N1o1 Nitric Oxide Serum and Age-Defiance Gel Cleanser can help achieve brighter, smoother, and radiant looking skin. So don’t be discouraged if you don’t see immediate changes – give it time for the natural ingredients to work their magic! Consistency is key when it comes to proper skincare. 

The Science

Nitric Oxide (NO) is a molecule that helps relax and widen blood vessels, improving circulation, oxygen delivery, and overall cardiovascular health. It also supports energy levels, endurance, and cognitive function.

Nitric oxide is naturally present in our bodies from birth, but its production declines with age, contributing to visible signs of skin aging like wrinkles, dark spots, fine lines, and reduced skin elasticity. Restoring Nitric Oxide levels can directly address these issues and slow down the signs of aging.
  • Stimulates collagen production for firmer, smoother skin
  • Enhances oxygen and hydration delivery to skin cells
  • Improves overall skin tone, texture, and clarity
  • Reduces the appearance of wrinkles, dark spots, and fine lines
Nitric oxide plays a crucial role in maintaining good oral health. It helps to improve blood flow and supports the body’s natural defenses against harmful bacteria. Additionally, it aids in saliva production, which is essential for keeping the mouth clean and neutralizing acids that can erode tooth enamel. Without enough nitric oxide, these functions can become compromised, leading to various oral health problems.

Pet Questions

Yes, small dogs can take 1/2 lozenge and larger dogs can take a whole lozenge.

Yes, you can sprinkle the Beetz powder on their food.