Feel Stronger. Perform Better. Stay Energized.
Your body depends on healthy circulation, endurance, and peak performance to thrive. But as you age, declining nitric oxide production can lead to low energy, reduced stamina, and poor blood flow.
That’s where N1o1 Nitric Oxide Lozenges come in. These powerful lozenges are specially formulated to release nitric oxide as they dissolve, providing numerous benefits to your body. Nitric oxide plays a crucial role in supporting blood flow and circulation, which helps deliver oxygen and nutrients to your muscles and organs. This improved circulation can enhance energy levels, endurance, and overall physical performance—perfect for workouts or staying active throughout the day. Additionally, nitric oxide supports cardiovascular health by relaxing blood vessels, helping to maintain healthy blood pressure. It also aids in improving cognitive function by increasing blood flow to the brain and boosting immune system performance by promoting better cellular communication. With N1o1 Nitric Oxide Lozenges, you can support your body on every level, helping you stay at your best—whether you’re at the gym, at work, or tackling your daily activities. Everyone deserves great blood flow!
The Decline of Nitric Oxide With Age
As we grow older, many bodily functions naturally begin to decline, including the production of nitric oxide. Research shows that by the time you reach 40, your body’s ability to produce nitric oxide can decrease by over 50%.
This decline can have significant effects on overall health, contributing to:
- Stiffened arteries and elevated blood pressure
- Reduced cognitive performance
- Lower exercise capacity and slower recovery
- Declined sexual function
- An increased risk of cardiovascular disease
In the pursuit of longevity and wellness, maintaining optimal nitric oxide levels isn’t just beneficial—it’s essential.








A Cortez –
I had so much focus that my eyeballs felt energy like my heart just took a dose of white powder. I had to get up and move around. I think around 30 minutes both, of my nostrils was able to take in oxygen like normal. This stuff really wakes you up, not just you, your whole you, from head to toe. I’m not promoter, but this stuff works. It did me anyway. Today as of 12/30/23 @ 12:45 was my first dose… Don’t chew it, slowly let it dissolve, too much at a time if you chew, it puts too much at one time in your system. I did feel great after taking it, I just have to keep my brain keeping up with my eyes…They’re at an all time “whoa” feeling. It’s not a bad whoa either. You may or may not enjoy the rush this product gives, but I enjoy it. Too each their own.
Ray Rusin –
One of the few products based on clinical studies supporting how the body actually supports NO production. These tabs utilize the oral pathway and highlights the importance of mouth biome.
John –
With this one I don’t ask myself, “did I get snookered? is this real? did I just get scammed?” plain and simple, it works and you can tell. zero ambiguity.
Richard –
I judge the effectiveness by blood oxygen saturation device. With this its 100 or 99 percent. works great.
C J –
I am soon to be on my 4th bottle. That speaks for its self in my opinion. I for sure like this product.. give it a try soon.
Emmanuel Igweh –
So quick story. I’ve been trying to quit coffee and go cold Turkey, I usually consumed about 3000 mg of caffeine a day due to work schedule.
My first week of coffee, I was so sleepy, that I fell asleep standing. So I started doing research. And I started taking B12 but it wasn’t enough so I supplemented with L arginine and L citrulline for that Nitric Oxide boost. But still wasn’t enough boost, and I came across Docs interview and tried this, and oh my God, I was able to wake up at 1:30 am and worked till 8 pm and still was able to have date night with high energy. This is awesome. And I can maintain my 12 – 16 hour work days. Oh and it helps in the indoor Olympics 😉 I just ordered 5 more
K J Spring –
A little expensive, but it is actually helping at least as far as I can tell. I’m revising this review with some evidence that it is working for me:
Firstly, I’m a 62-year-old male in relatively decent shape. I work out in my home gym 1hr+ each week day and 1/2 hr. on weekends. I very rarely miss a workout. I track myself on an Apple watch. I have maintained this pattern for about 5 years now. Before that I was 50lbs overweight and did not work out for quite a few years and obviously wasn’t careful about what I ate.
Okay, for Christmas I received a bottle of this product. I had my blood pressure taken at a Dr. appt. after using the first bottle. It was 102/60 which I was told is excellent. I’ve always had good blood pressure, but nothing like this. Secondly, for my 1/2-hour workout on Saturdays and Sundays, I run, in place, in my office/ gym. I do not have treadmill, so my metrics are me against me. I have typically ‘run’ about 3 – 3.5 miles in 30 minutes and burned about 400 – 430 calories in that time. After using this product for a month (and continuing to use it) I have seen significant improvement. I just finished a ‘run’ and ran 4.5 miles burning 598 calories. The only reason I didn’t go farther and burn more calories is because I have 62-year-old bones and joints and I could tell I was going to injure myself if I exerted myself more. It was not due to a lack of energy.
One more thing to note that I believe could be impacting my performance and the gains I’m seeing from using this product is that I have taken Vitamin K2 and Nattokinase for quite a while. It is my understanding that both of these supplement’s help keep the arteries and veins clear. Also, in 2018 I went off all ‘added’ sugar except for 1 cheat day a week. I don’t know, but I suspect that both of these things may have improved the efficacy of these lozenges. Oh, finally, as per Dr. Bryan’s recommendations, I do not use a mouth wash and use a non-fluoride toothpaste. Good health all!
Gwina Baek –
I started school at my late 30’s. However, it was difficult to focus on studying. Then, I decided to try this and… wow, I can focus much better than before! Also when I exercise, I feel much less muscle ache. I will order my second bottle soon!
David Rogers –
Blisters on roof of mouth after taking product will try again after it heals don’t understand why since I don’t see any data on that problem
Alyssa Seidler (verified owner) –
Hi David, We’re sorry to hear you are experiencing irritation from the lozenges. This can happen for a few reasons.
1. You may be experiencing an irritation from the vitamin C in the lozenge. You can chew the lozenge followed by 5-6 ounces of water and this should alleviate the irritation. You will still receive the same benefits from the nitric oxide production.
2. The irritation can also be caused by the acidity levels in your mouth. You can try swishing a teaspoon of baking soda in your mouth with water, and spitting it out before taking the lozenge to reduce the acidity.
3. You could substitute the lozenges with our N.O. Beetz drink powder sachets. The drink powder is mixed with water and drank similarly to an electrolyte drink sachet. The N.O. Beetz are just as effective as the lozenge. Please reach out to our support team if we can assist any further.
Michael Degnen –
I’ve been trying to lower my blood pressure naturally, I have a withings cuff and have been tracking it for a while. My blood pressure sits around 135 over 90, 24h after starting this product I was 125 over 80
Terence Matheson –
Great
Chris Harrey –
I love this product it really really helps me but Im at a point now I cant take them anymore due to them making the sides and roof of my mouth really sore and swollen. I withstood it for some time but now its effecting the way I smile and even talk and as a saleman I need to not pull weird facial expressions when im with a customer. Is there any round round this? What could be causing this problem? Im really dissaponted I cant use it anymore it helped so much all round and I would really love another solution but I undertsand the tabs need to be sucked and this isnt good for me anymore. Any help would be greatly apprecited.
Alyssa Seidler (verified owner) –
Hi Chris, We’re sorry to hear you are experiencing irritation from the lozenges. This can happen for a few reasons.
1. You may be experiencing an irritation from the vitamin C in the lozenge. You can chew the lozenge followed by 5-6 ounces of water and this should alleviate the irritation. You will still receive the same benefits from the nitric oxide production.
2. The irritation can also be caused by the acidity levels in your mouth. You can try swishing a teaspoon of baking soda in your mouth with water, and spitting it out before taking the lozenge to reduce the acidity.
3. You could substitute the lozenges with our N.O. Beetz drink powder sachets. The drink powder is mixed with water and drank similarly to an electrolyte drink sachet. The N.O. Beetz are just as effective as the lozenge. Please reach out to our support team if we can assist any further.
Lena Kroessig –
I am very EMF sensitive and my blood pressure is already down 30 and 25 points! And I feel great. Calmer, happier. I felt the difference right away, but waited four days before checking my progress. There are no wireless devices in our home. I’m suspicious of the new Omron BP machine. Like so many new appliances these days, EMF pulses are coming from medical devices, like my husband’s CPAP machine. We are the only ones in our neighborhood that opted out of the smart meter installations. I have always had 120/80 blood pressure. Never been on medication for that. I quit most sweet drinks and treats years ago and we are buying most of food from farmers we know and trust. My husband is waiting to see how I do as he is on plenty of medications and wants to talk to his cardio guy. So happy that I came across Dr. Nathan S. Bryan. Thank you.
Helen (verified owner) –
When I initially took the first tablet I wondered if Dr Bryan hadn’t simply mixed some chalk with a stimulant because my head cleared instantly and I got a bit of heat in my chest. However, about 4 hours later I noticed a strong sensation of pins and needles and heat in my feet! The amazing clarity in my head has not gone off now 2 days after taking the pill (so it’s not an artificial stimulant!) and the ankle – the one I tore a ligament in just on 20 years ago – started throbbing again, the way it only throbs after I’ve spent a day in the hot tub. I also noticed that I have INCREDIBLE sinus drainage down my right side (only the right side) and that I used to still get horriffic stabbing pains in the inner corner of my right eyebrow every now and again…and now every time I swallow I can feel it draining down the right side. To add, I slept 9 hours back to back last night, something that hasn’t happened for years. I am delighted with the purchase and will definitely be buying more for myself and my family!
James Chavira (verified owner) –
I’ve been popping one of these lozenges every morning for a few weeks, and I genuinely feel more energized—my circulation seems smoother, and my workouts even feel easier now.
Kai Lopuk (verified owner) –
It dissolves nicely and my blood pressure has noticeably improved—real results without extra meds. I’m officially hooked
Amanda Bodini (verified owner) –
I wasn’t expecting much at first, but these lozenges deliver. I feel clearer in the brain, and my blood flow feels more balanced—like my body’s functioning better
Mark Charles (verified owner) –
I’ve tried other heart and circulation supplements before, but this is different. These lozenges are easy, clean, and they actually work—my energy and blood pressure both say so
Jennifer Castro (verified owner) –
After taking the lozenge, I noticed my cognitive thinking was on point and my mood is lifted. I no longer take an energy drink in the morning that I was drinking before taking the lozenge. I feel more energized and focused!
Dawn Frier (verified owner) –
When I went to reorder I noticed a couple reviews that really caught my attention. My tongue and roof of mouth have been white/lacey for months now. These reviews warned about sensitivity to the lozenges and I read in the response from the company what to do. I decided to stop the lozenges and lo and behold in a couple days all the white went away. Because these lozenges are valuable to me in a big way I decided to follow what the company said to do to minimize the impact of the Vitamin C (why do you have to add that anyway?) and restarted them. And lo and behold the mysterious thick white went away after just a few days! I have restarted the lozenges by chewing them and swishing out my mouth multiple times and the thick white has not returned – there is still a little white). If I stop the lozenges again I’m sure the remaining white would go away so I’m living with it. I am so grateful for these reviews. Please take out the slew of additives to the product – there are so many!! I would rather consume something pure and it not taste great than have a product with things like Malodextrin and Natural Flavors, etc.
Alyssa Seidler (verified owner) –
Hi Dawn, We’re sorry to hear you are experiencing irritation from the lozenges. This can happen for a few reasons.
1. You may be experiencing an irritation from the vitamin C in the lozenge. You can chew the lozenge followed by 5-6 ounces of water and this should alleviate the irritation. You will still receive the same benefits from the nitric oxide production.
2. The irritation can also be caused by the acidity levels in your mouth. You can try swishing a teaspoon of baking soda in your mouth with water, and spitting it out before taking the lozenge to reduce the acidity.
3. You could substitute the lozenges with our N.O. Beetz drink powder sachets. The drink powder is mixed with water and drank similarly to an electrolyte drink sachet. The N.O. Beetz are just as effective as the lozenge. Please reach out to our support team at support@n1o1.com if we can assist any further.
j. shutt (verified owner) –
I was a walking dead man and now I’m well. one year later at 71 and see no end. Thanks doc
Darrell hoover (verified owner) –
Thank you Dr. Nathan Bryan for your good work. Bringing safe nitric oxide products to the market that actually work
Avo Iz –
This product is truly incredible. Its helped me a lot in the gym and overall feeling more energy and clarity of mind! Also, I’ve gotten multiple family members on it whom are diabetic and they’ve all reported very positive results and increased energy, better blood sugar levels and improved mood!
Matt –
I’ve been using the lozenges for a few weeks now and I’m genuinely impressed. My energy is up and I noticed my focus has been much better. Love this product. Definitely worth trying.
Derrick R –
These lozenges are a game changer! Since I started using them I have more energy, more focus, and I just feel better. I was skeptical at first but one bottle has convinced me that these are the real deal.
dan desalvo (verified owner) –
Mitopure and N1O1 have been in my supplement repertoire since their development. I take them at the same time and have noticed energy, body temperature especially when accompanied by raw beets in my diet.
I’m 76 years old, scienced based and realize I don’t have much time left to metabolically change and improve upon. I primarily focus upon supplements which will benefit my blood circulation…the “plumbing” if you will.
Veronica W –
I am amazed! I am a female, 62 yrs old who has battled weight her whole life . Went off Wegovy over a year ago (side effects) gained all weight back. Was researching how to support GLP production in the body when I came across a great podcast (Diary of a CEO) with Dr. Bryan as the guest. Bought the lozenge, the beet supplement and the toothpaste, I’ve been using it in conjunction with another product called RxSugar and 5 weeks later I’ve lost 12 pounds with out any special effort or change to diet or workout schedule. It really does work like the Wegovy did for me because now I can once again feel when I’m full and the racing thoughts that obsess on food have stopped. I row with a women’s team and I play pickleball, the beet supplement really helps my energy levels and endurance (I have found that mixing it with tea or coffee to drink it down masks the taste) I still have a long way to go on my weight loss journey but now my body is responding again which is amazing (and no shots that make me nauseous and headachy). Thank you from the bottom of my heart for some great products I’m a believer and next I’m switching over to your skin care line!
Jeff (verified owner) –
Been using the lozenges for a couple of weeks and feel like that have been quite beneficial.
Ronnie Taga (verified owner) –
I simply love taking the N1o1 nitric oxide lozenges. It’s a great boost for my health, cognitive function, energy and supports my heart health. Nobody in the nitric oxide space comes close to Dr. Bryan’s expertise.
Laura Berggruen (verified owner) –
Loving the lozenges! My blood pressure is down and my energy is up! Very happy with my results!
MARCIA L GARY (verified owner) –
I just started taking the lozenges and believe they will assist me in my health journey. If I wasn’t retired, I would buy some for a number of my family and friends. Really wonderful and effective product. Thank you Dr. Bryan.
Mari –
My last BP check at my Dr’s was 156/98. My BP had hovered around that mark for 5 years and I was at the point where I couldn’t ignore it any longer. After 4 days of 2 lozenges + 1 beetz sachet daily my BP, at last check, was 116/68……AMAZING! I’m so happy that I’ve found something that not only demonstrably works, but worked so quickly. Happy, happy, happy 🙂