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Cardiosmile – The worlds FIRST N.O. boosting toothpaste!

N1o1 Nitric Oxide
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N1o1 Inside & Out Glow Collection
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N1o1 Inside & Out Glow Collection

Your Daily Ritual for Unmatched Wellness

Imagine a routine where every step enhances your health. Start your morning with a smile that supports your heart. Boost your afternoon with natural energy. End your day with a skincare routine that combats the effects of time.

The N1o1 Inside & Out Glow Collection is more than just products—it’s a pathway to a healthier, more vibrant life. This complete nitric oxide system works seamlessly to support your heart, improve blood flow, boost natural energy, and care for your skin and oral health.

Featuring:

This complete collection enhances your body’s nitric oxide production, addressing the root causes of aging skin and promoting overall wellness. Nitric oxide is an essential molecule that improves skin elasticity and texture, leading to firmer, smoother, and more revitalized skin. Beyond skincare, increased nitric oxide supports better circulation, contributing to improved energy and vitality. Our formulas are grounded in Nobel Prize-winning science, providing scientifically validated, visible results.

$409.38

N1o1 inside out glow collection

Unlock Your Best Health. Look and Feel Your Best.

Healthy nitric oxide levels are crucial for optimal health. However, as we age, our natural nitric oxide production declines, leading to low energy, reduced stamina, poor blood flow, and negative impacts on skin and oral health.

N1o1 Nitric Oxide solutions offer comprehensive, whole-body care. Our innovative collection, backed by over 25 years of research, supports your body’s natural systems—from nutrition to oral care and skincare. From strengthening your oral microbiome and promoting healthy gums to nourishing your skin and supporting heart health, N1o1 formulas help you look and feel your best every day. Redefine self-care with N1o1.

What’s Inside

For Internal Health & Vitality:

N1O1-Nitric-Oxide-Lozenges

N1o1 Nitric Oxide
Lozenges:

Get a rapid boost of vitality with these quick-dissolve lozenges. Perfect for on-the-go support, they are scientifically designed to promote healthy circulation, blood pressure, and cardiovascular function within minutes.

Benefits:

  • Supports blood flow and circulation
  • Supports cardiovascular health
  • Supports nitric oxide production
  • Protection against oxidative stress
  • Supports cognitive health
  • Supports organ system functions
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N.O. Beetz (Fermented Beets Powdered Drink Mix):

Fuel your day and enhance your workouts with this clean, delicious energy source. This unique oxalates-free, beet-based formula provides sustained stamina and electrolytes and antioxidant support without the jitters, mess, or earthy taste.

Benefits:

  • Improves blood flow and circulation
  • Enhances natural energy and endurance
  • Supports cardiovascular health
  • Supports nitric oxide production
  • Improved cellular hydration with electrolytes
  • Reduces oxidative stress
N1o1 CardioSmile Nitric Oxide Toothpaste fluoride free

CardioSmile Nitric Oxide Toothpaste:

Transform your daily routine with the only toothpaste that generates nitric oxide. It’s fluoride free and supports a healthy oral microbiome—the gateway to systemic health—while whitening teeth and freshening breath, all without fluoride.

Benefits:

  • Boosts your mouth's natural microbiome
  • Improves blood flow and circulation
  • Fluoride free formula, safe from harmful toxins and ingredients
  • Supports cardiovascular health
  • Supports nitric oxide production

For Age-Defying Skincare:

N1o1 gel cleanser transparent

Age-Defiance Gel Cleanser:

Begin your skincare ritual with this gentle, effective cleanser. Rich in Alpha-Hydroxy Acids (AHAs) and soothing botanicals like Green Tea and Aloe, it exfoliates, brightens, and oxygenates, preparing your skin for optimal rejuvenation.

N1O1 Age-Defiance Serum by Dr. Nathan Bryan

Age-Defiance
Serum:

Experience the first and only serum that generates nitric oxide directly on your skin. This potent dual-chamber formula is clinically proven to reduce the appearance of wrinkles, improve skin tone, and restore a youthful, radiant glow by stimulating collagen and revitalizing skin cells.

N1o1 Nitric Oxide Boosting Age Defiance Eye Cream

Age-Defiance Eye Cream:

Revitalize the delicate skin around your eyes. This targeted cream combines nitric oxide, Hyaluronic Acid, and complex peptides to diminish dark circles, reduce puffiness, and smooth away fine lines and crow’s feet for a brighter, more awake appearance.

Age-Defiance Face Cream Skincare Lasting Radiance, Lasting Value

Age-Defiance Face Cream:

Lock in hydration and amplify your results with this luxurious, peptide-rich face cream. Infused with Epidermal Growth Factor (EGF), it stimulates collagen and elastin, leaving your skin feeling firm, supple, and deeply nourished.

N1o1 4 Step Skincare Routine

Benefits:

  • Boosts circulation & oxygen flow in skin
  • Revived glow & elasticity
  • Targets the root cause of aging skin
  • Visibly firmer, smoother skin
  • N1o1 Nitric Oxide Age-Defiance Serum is clinically proven in 5 studies to improve skin health, tone, texture and clarity

Essential for Your Health

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Why the N1o1 Inside & Out Glow Collection is
Essential for Your Health & Wellness

The full N1o1 product line is designed to support your body’s natural nitric oxide production, promoting health and vitality from the inside out. The Nitric Oxide Lozenges and N.O. Beetz boosts circulation, energy, and overall vitality, while CardioSmile supports cardiovascular health. For skincare, the Nitric Oxide Activating Age-Defiance Serum, Gel Cleanser, Eye Cream, and Face Cream work together to restore firmness, radiance, and resilience. With N1o1, you can experience comprehensive well-being and age-defying results.

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Synergistic Formulas

The cleanser preps your skin, the serum repairs it, and the lozenges boost internal nitric oxide. Together, they deliver maximum nitric oxide activation for skin and body.

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Targeted Anti-Aging & Wellness

Supports memory, focus, cognitive clarity, heart health, and overall physical performance by optimizing your nitric oxide levels, both topically and internally.

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Backed by Biochemistry

Created by Dr. Nathan S. Bryan, world-renowned nitric oxide researcher.

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Biohacker Approved

Promotes healthy blood pressure, circulation, and overall cardiovascular function, while visibly improving oral health and skin health.

N1o1 science meets simplicity

Science Meets Simplicity

Clean, effective, non-toxic formulas that just work, fitting seamlessly into your daily routine.

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Long-Term Results

Not a quick fix. A proven routine for sustained, visible skin improvement and enhanced overall health. Experience the profound difference nitric oxide can make for your skin, oral care and overall wellness.

Shop the Collection

Science-Backed Ingredients

Science Backed Ingredients

N1O1 Nitric Oxide Lozenges front back

Nitric Oxide Lozenges

Key Ingredients & Benefits:

  • Vitamin C & Magnesium: Essential nutrients that support overall health and may aid in nitric oxide production.
  • N1o1™ Proprietary Blend (Magnesium Ascorbate, Sodium Nitrite): Designed to activate and boost nitric oxide levels.
  • Stevia, Monk Fruit: Natural sweeteners.

Vitamin C (from Magnesium Ascorbate), Magnesium (from Magnesium Ascorbate), N1o1™ Proprietary Blend [Magnesium Ascorbate, Sodium Nitrite], Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltodextrin, Stearic Acid, Vegetable Stearate, Food Starch – Modified, Starch, Silica, Stevia, Citric Acid, Monk Fruit

N1o1 N.O. Beetz

N.O. Beetz

Key Ingredients & Benefits:

  • Vitamins C & D: Antioxidant and immune support.
  • Magnesium, Zinc, Manganese, Sodium, Potassium: Key electrolytes and minerals for body function.
  • NO2U™ Proprietary Blend: Formulated for nitric oxide activation.
  • Fermented Beet Root Powder: Rich in nitrates, supporting nitric oxide production and circulation.
  • D-Ribose & PEAK ATP®: Support cellular energy and performance.

Vitamin C (as Ascorbic Acid), Vitamin D (as Cholecalciferol), Magnesium (as DiMagnesium Malate), Zinc (as Zinc Bisglycinate Chelate), Manganese (as Manganese Bisglycinate Chelate), Sodium, Potassium, NO2U™ Proprietary Blend, Fermented Beet Root Powder, D-Ribose, PEAK ATP® (Adenosine 5′-Triphosphate Disodium), Citric Acid, Sea Salt, Rebaudioside A (Stevia Extract), Malic Acid, Natural Flavor

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CardioSmile Nitric Oxide Toothpaste

Key Ingredients & Benefits:

  • Potassium Nitrate: Helps reduce tooth sensitivity.
  • Xylitol: Aids in cavity prevention and promotes oral health.
  • Hydroxyapatite: Supports enamel remineralization for stronger teeth.
  • Zinc Citrate: Helps control plaque and gingivitis.
  • Peppermint, Spearmint, Wintergreen, Tea Tree, Eucalyptus, Thyme Oils: Provide fresh breath and natural antiseptic properties for oral hygiene.

Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite 4 Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulvaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate

N1o1 Age Defiance Gel Cleanser Ingredients

Age-Defiance Exfoliating Gel Cleanser

Key Ingredients & Benefits:

  • Glycolic Acid, Lactic Acid, Citric Acid, Tartaric Acid, Malic Acid (AHAs): Gently exfoliate, promoting brighter and smoother skin.
  • Fruit Extracts (Passionfruit, Pineapple, Grape): Natural sources of AHAs and antioxidants for skin renewal.
  • Aloe Barbadensis Leaf Juice: Soothes and hydrates the skin.
  • Ascorbic Acid (Vitamin C): Provides antioxidant protection and brightens skin tone.

Water, Ammonium Lauryl Sulfate, Glycerin, Hydroxyethylcellulose, Potassium Oleate, Potassium Cocoate, Glycolic Acid, Lactic Acid, Citric Acid, Tartaric Acid, Malic Acid, Passiflora Edulis Fruit Extract, Ananas Sativus (Pineapple) Fruit Extract, Vitis Vinifera (Grape) Fruit Extract, Aloe Barbadensis Leaf Juice, Algae Extract, Ascorbic Acid, Camellia Oleifera Leaf Extract, Lonicera Caprifolium (Honeysuckle) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Propanediol, Cola Acuminata Seed Extract, Polysorbate 20, Fragrance, Alcohol Denat., Potassium Citrate, Tetrasodium EDTA

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Nitric Oxide Activating Anti-Aging Serum

Key Ingredients & Benefits:

  • Ascorbic Acid (Vitamin C): A potent antioxidant that helps brighten skin and support collagen production.
  • Sodium Nitrite: Works to activate nitric oxide, supporting skin repair and renewal.
  • d-Tocopheryl Acetate (Vitamin E): Offers antioxidant protection, safeguarding skin from environmental damage.

Water, Ascorbic Acid (Vit. C), Polysorbate 20, Hydroxyethylcellulose, Sodium Nitrite, d-Tocopheryl Acetate (Vit. E), Dehydroacetic Acid, Benzyl Alcohol, Sodium Sulfite, Sodium Metabisulfite, Tetrasodium EDTA.

N1o1 Nitric Oxide Boosting Age Defiance Eye Cream Ingredients

Nitric Oxide Boosting Age-Defiance Eye Cream

Key Ingredients & Benefits:

  • Sodium Nitrite: Boosts nitric oxide to promote skin health and radiance.
  • Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7: A powerful peptide complex that helps reduce the appearance of fine lines and wrinkles.
  • Ceramides (NP, NS, EOS, EOP, AP): Essential lipids that strengthen the skin’s natural barrier, locking in moisture and protecting against environmental damage.
  • Sodium Hyaluronate & Squalane: Provide intense hydration, plumping the skin to reduce dryness and improve elasticity.
  • Cucumber & Green Tea Extracts: Soothe and calm the delicate skin around the eyes while offering antioxidant protection.

Water, Helianthus Annuus (Sunflower) Seed Oil, Cetearyl Alcohol, Glyceryl Stearate SE, Squalane, Dimethicone, Garcinia Indica Seed Butter, Ceteareth-20, Glycerin, Sodium Nitrite, Magnesium Aluminum Silicate, Sodium PCA, Palmitoyl Tripeptide-5, Coconut Alkanes, Propanediol, Polyacrylamide, Sodium Hyaluronate, Tremella Fuciformis (Mushroom) Extract, Palmitoyl Tripeptide-1, Dicaprylyl Ether,N-Hydroxysuccinimide, Camellia Sinensis Leaf Extract, Cetyl Alcohol, Palmitoyl Tetrapeptide-7, Cetyl Esters, Dunaliella Salina Extract, Cocos Nucifera (Coconut) Oil, C13-14 Isoparaffin, Cucumis Sativus (Cucumber) Fruit Extract, Biosaccharide Gum-1, Ceteareth-25, Steareth-20, Laureth-7, Behenic Acid, Phenoxyethanol, Cholesterol, Cocos Nucifera (Coconut) Liquid Endosperm, Ceramide NP, Ceramide NS, Ceramide EOS, Ceramide EOP, Ceramide AP, Chrysin, Cocos Nucifera (Coconut) Fruit Juice, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Caprylyl Glycol, Panthenol, Coco-Caprylate/ Caprate, Lecithin, Titanium Dioxide.

N1o1 Nitric Oxide Boosting Age Defiance Face Cream Ingredients

Nitric Oxide Boosting Age-Defiance Face Cream

Key Ingredients & Benefits:

  • Sodium Nitrite: Boosts nitric oxide in the skin to promote a revitalized, healthy-looking complexion.
  • Peptide Complex (Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, sh-Polypeptide-11): A powerful blend of growth factors and peptides that work to firm the skin and visibly smooth wrinkles and fine lines.
  • Squalane & Sodium Hyaluronate: Provide deep hydration, helping to leave the skin feeling soft, supple, and plump.
  • Botanical Extracts (Arnica, Hops, Rosemary): A blend of natural extracts known for their soothing and antioxidant properties, helping to protect the skin from environmental stressors.
  • Grape Seed Oil & Hydrogenated Olive Oil: Rich in fatty acids and antioxidants, these oils nourish and condition the skin, promoting a smooth, healthy texture.

Water, Vitis Vinifera (Grape) Seed Oil, Cetearyl Alcohol, Glyceryl Stearate SE, Squalane, Ceteareth-20, Glycerin, Sodium Nitrite, Magnesium Aluminum Silicate, Sodium PCA, Sodium Hyaluronate, Butylene Glycol, Polyacrylamide, Palmitoyl Tripeptide-1, Lecithin, Acetyl Glutamine, Palmitoyl tetrapeptide-7, sh-Oligopeptide-1, sh-Oligopeptide-2, Arnica Montana Flower Extract, Cetyl Esters, Humulus Lupulus (Hops) Extract, sh-Polypeptide-1, sh-Polypeptide-9, Equisetum Hyemale Extract, sh-Polypeptide-11, Pinus Strobus Cone Extract, Lecithin, Bacillus/Folic Acid Ferment Filtrate Extract, Hydrogenated Ethylhexyl Olivate, Hydrogenated Olive Oil Unsaponifiables, Citrus Limon (Lemon Bioflavonoids) Peel Extract, Rosmarinus Officinalis (Rosemary) Extract, C13-14 Isoparaffin, Phenoxyethanol, Cetyl Alcohol, 1,2-Hexanediol, Caprylyl Glycol, Laureth-7, Polysorbate 20, Carbomer, Titanium Dioxide.

Meet Dr. Bryan

About Dr Nathan Bryan e1760108713984

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

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A Pioneer in Nitric Oxide Science

With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on nitric oxide’s role in human health.

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Clinically Backed & Scientifically Proven

His discoveries have shaped the field of nitric oxide therapy, leading to cutting-edge solutions like the Inside & Out Glow Collection you’re about to experience.

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On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of nitric oxide—so they can live longer, healthier, and more vibrant lives.

Studies

[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
 Annals of Plastic  & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF

[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF

[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF

[5] A Novel Combination Therapy in Aesthetic and Reconstructive Surgery: Sea Salt Exfoliation, Cavitating Ultrasound, and High Intensity Multiwavelength LED Treatment: (SaltFacial)
Sciforschen Journal of Clinical and Cosmetic Dermatology
Greg Chernoff, BSc, MD, FRCSC*
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[6] Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
PubMed
Sandesh C S Nagamani, Philippe M Campeau, Oleg A Shchelochkov, Muralidhar H Premkumar, Kilian Guse, Nicola Brunetti-Pierri, Yuqing Chen, Qin Sun, Yaoping Tang, Donna Palmer, Anilkumar K Reddy, Li Li, Timothy C Slesnick, Daniel I Feig, Susan Caudle, David Harrison, Leonardo Salviati, Juan C Marini, Nathan S Bryan, Ayelet Erez, Brendan Lee
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Download the PDF

[7] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF

[8] Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Download the PDF

[9] Nitric oxide enhancement strategies
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Download the PDF

[10] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile

  • Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
  • Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
  • Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
  • Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

Download the PDF

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