Nitric Oxide Boosting Age-Defiance Eye Cream

(15 customer reviews)

Revitalize Your Eyes with the Power of Nitric Oxide

Developed by Dr. Nathan S. Bryan, our Nitric Oxide Boosting Age-Defiance Eye Cream is specifically designed to target the delicate skin around your eyes. By improving microcirculation at the cellular level, this advanced formula reduces the appearance of fine lines, wrinkles, puffiness, and dark circles. Infused with collagen boosters, peptides, hyaluronic acid and ceramides, it hydrates deeply while enhancing firmness and elasticity. The result? Brighter, smoother, and more youthful-looking eyes every day.

  • Potentiates nitric oxide production to support healthy, radiant skin.
  • Reduces puffiness and dark circles for a refreshed appearance. 
  • Visibly smooths fine lines and wrinkles around the eyes.
  • Improves skin texture and elasticity, restoring youthful firmness.
  • Deeply hydrates and nourishes the delicate under-eye area.

Maximum of 2 per order.

$59.98 or subscribe to save 10%

In stock

N1o1 Nitric Oxide Boosting Eye Cream Ludi Delfino

Treat the Delicate Eye Area

Healthy nitric oxide levels are essential for optimal microcirculation, which is key to maintaining a vibrant, youthful appearance. As we age, natural nitric oxide production declines, leading to visible signs of aging like dark circles, puffiness, and fine lines.

N1o1’s Nitric Oxide Boosting Age-Defiance Eye Cream works synergistically with our Nitric Oxide Activating Serum to restore nitric oxide levels, improving blood flow and oxygen delivery to the skin. This innovative process helps reduce puffiness, brighten dark circles, and smooth fine lines, leaving your eyes looking refreshed and rejuvenated.

N1o1 nitric oxide age defiance eye cream benefits

What Makes the Nitric Oxide Boosting Age-Defiance Eye Cream Unique?

Unlike most eye creams that only address surface-level concerns, N1o1’s formula works at the cellular level to transform your skin from within. Backed by Nobel Prize-winning nitric oxide science, this eye cream is expertly crafted with four powerful anti-aging ingredients to target and revitalize the delicate under-eye area: 

  • Nitric Oxide: The foundation for healthy, radiant skin. 
  • Complex Peptide Formula: Rejuvenates and restores youthful firmness. 
  • Hyaluronic Acid: Hydrates and locks in moisture for smoother, plumper skin. 
  • Ceramides: Strengthens the skin’s natural barrier to retain moisture and defend against environmental damage.

Experience the visible transformation as our advanced formula revitalizes your under-eye area, reducing the appearance of wrinkles, puffiness, and dark circles. 

Additional information

Weight .3 oz
Dimensions 2 × 2 × 2 in

How To Use

N1o1 Nitric Oxide Age Defiance Eye Cream How to Use

How to Use for Optimal Results

For brighter, smoother, and more youthful-looking eyes, use the Nitric Oxide Boosting Age-Defiance Eye Cream twice daily.

Your Morning & Night Ritual:

  1. Apply a small amount to clean, dry skin around the eyes.
  2. Gently pat with your ring finger until fully absorbed.


Storage:

To maintain potency, store in a cool, dark place and use before the expiration date printed on the package.

N1o1 Dr. Nathan S Bryan Nitric Oxide Boosting Eye Cream

What to Expect

Our formula works at a cellular level to address visible signs of aging around the eyes. By improving microcirculation with nitric oxide, it reduces puffiness, brightens dark circles, and smooths fine lines. With consistent use, you’ll notice a firmer, more youthful appearance.

Pairs effectively with: 


Within 30 Days:

Most users report visible improvements in the appearance of dark circles, puffiness, and fine lines within the first 30 days of consistent use.

Why Nitric Oxide Matters

N1o1 Nitric Oxide Age Defiance Eye Cream Benefits

Why Nitric Oxide Matters for Your Skin

Nitric oxide is a vital molecule that enhances microcirculation, delivering oxygen and nutrients to your skin cells. This improved blood flow helps reduce puffiness, brighten dark circles, and smooth fine lines. By supporting cellular repair, nitric oxide revitalizes the delicate under-eye area, leaving your skin looking healthier, stronger, and more radiant.

Ingredients

Ingredients

Our formula blends advanced scientific ingredients with nourishing botanicals to deliver age-defying results while supporting skin health. It hydrates, smooths, and brightens the under-eye area, leaving your skin refreshed and rejuvenated.

Sodium Nitrite

Nitric Oxide–Activating Component (Sodium Nitrite)

Boosts circulation to brighten and revitalize the skin.

Multi Peptide

Multi-Peptide Complex (Palmitoyl Tripeptide-1, -7, -5)

Improves firmness and reduces the look of fine lines.

Ceramide

Ceramide Complex (Ceramide NP, NS, EOS, EOP, AP)

Reinforces the skin barrier for improved hydration and resilience.

Advanced Hydration

Advanced Hydration Matrix (Sodium Hyaluronate, Sodium PCA, Tremella Fuciformis Extract)

Locks in moisture for a plumper appearance.

Nourishing Lipids Emollients

Nourishing Lipids & Emollients (Sunflower Seed Oil, Squalane, Garcinia Indica Seed Butter, Coconut Oil)

Soften skin and support its natural barrier.

Botanical Antioxidants Soothers

Botanical Antioxidants & Soothers (Green Tea, Cucumber, Dunaliella Salina Extract)

Calm and protect the delicate under-eye area.

Coconut Derived Actives

Coconut-Derived Actives (Coconut Liquid Endosperm & Fruit Juice)

Deliver essential nutrients and hydration.

Skin Soothing Agents

Skin-Soothing Agents (Chrysin, Panthenol, Biosaccharide Gum-1)

Reduce puffiness and soothe the under-eye area.

N1o1 Nitric Oxide Age Defiance Eye Cream Ingredients

Full Ingredient List

Water, Helianthus Annuus (Sunflower) Seed Oil, Cetearyl Alcohol, Glyceryl Stearate SE, Squalane, Dimethicone, Garcinia Indica Seed Butter, Ceteareth-20, Glycerin, Sodium Nitrite, Magnesium Aluminum Silicate, Sodium PCA, Palmitoyl Tripeptide-5, Coconut Alkanes, Propanediol, Polyacrylamide, Sodium Hyaluronate, Tremella Fuciformis (Mushroom) Extract, Palmitoyl Tripeptide-1, Dicaprylyl Ether,N-Hydroxysuccinimide, Camellia Sinensis Leaf Extract, Cetyl Alcohol, Palmitoyl Tetrapeptide-7, Cetyl Esters, Dunaliella Salina Extract, Cocos Nucifera (Coconut) Oil, C13-14 Isoparaffin, Cucumis Sativus (Cucumber) Fruit Extract, Biosaccharide Gum-1, Ceteareth-25, Steareth-20, Laureth-7, Behenic Acid, Phenoxyethanol, Cholesterol, Cocos Nucifera (Coconut) Liquid Endosperm, Ceramide NP, Ceramide NS, Ceramide EOS, Ceramide EOP, Ceramide AP, Chrysin, Cocos Nucifera (Coconut) Fruit Juice, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Caprylyl Glycol, Panthenol, Coco-Caprylatel Caprate, Lecithin, Titanium Dioxide.

Dr. Bryan

About Dr Nathan Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

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A Pioneer in Nitric Oxide Science

With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

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Clinically Backed & Scientifically Proven

His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the Nitric Oxide Boosting Age-Defiance Eye Cream you’re about to experience.

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On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

FAQs

How does nitric oxide improve the look of my under-eye area?

Nitric oxide enhances microcirculation, delivering oxygen and nutrients to your skin cells. This process helps reduce puffiness, brighten dark circles, and smooth fine lines, leaving your eyes looking refreshed and youthful.

Yes. The Nitric Oxide Boosting Age-Defiance Eye Cream is gentle yet effective for all skin types, including sensitive, oily, dry, and combination skin.

Many users experience a refreshed appearance after the first application. With consistent use, most report visible improvements in dark circles, puffiness, and fine lines within 30 days.

Yes. Formulated by Dr. Nathan S. Bryan, this eye cream is backed by clinical studies and is vegan, cruelty-free, gluten-free, and non-GMO.

Ready to unlock your eyes’ full potential?

Add the N1o1 Nitric Oxide Boosting Age-Defiance Eye Cream to your routine and reveal brighter, smoother, and more youthful-looking eyes.  

Studies

[1] Dermal Nitrite Application Enhances Global Nitric Oxide Availability: New Therapeutic Potential for Immunomodulation?
Journal of Investigative Dermatology
Maria Francisca Garcia-Saura, Bernadette O. Fernandez, Brian P. McAllister, David R. Whitlock, William W. Cruikshank, Martin Feelisch
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA
Nitroceutic LLC, Dover, Massachusetts, USA
Download the PDF

[2] Nitric oxide therapy for dermatologic disease
PubMed
Brandon L Adler, Adam J Friedman
Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA
Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
George Washington School of Medicine & Health Sciences, Washington, DC, USA
Download the PDF

[3] Nitric Oxide Signal Transduction and Its Role in Skin Sensitization
PubMed
Jong Hun Kim, Min Sik Choi
Department of Food Science and Biotechnology, and Institute for Basic Sciences, Sungshin Women’s University, Seoul 01133, Republic of Korea
Lab of Pharmacology, College of Pharmacy, Dongduk Women’s University, Seoul 02748, Republic of Korea
Download the PDF

[4] Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review
PubMed
Andrada Pintea, Andrei Manea, Cezara Pintea, Robert-Alexandru Vlad, Magdalena Bîrsan, Paula Antonoaea, Emöke Margit Rédai, Adriana Ciurba
Medicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania
Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures
Department of Drug Industry and Pharmaceutical Biotechnology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Download the PDF

[5] Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
PubMed
Sekyoo Jeong, Seokjeong Yoon, Sungwoo Kim, Juyeon Jung, Myungho Kor, Kayoung Shin, Chaejin Lim, Hyo Sun Han, Haekwang Lee, Kyeong-Yong Park, Jinwan Kim, Hwa Jee Chung, Hyun Jung Kim
Research Division, Incospharm Corporation, Daejeon 34036, Korea
P&K Skin Research Center Company Limited, Seoul 07236, Korea
Research Division, Cha Meditech Corporation, Daejeon 34025, Korea
CHA Bio F&C, Seongnam 13488, Korea
Department of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea
See The Study

[6] A review of the efficacy of popular eye cream ingredients
PubMed
Hanin Hamie, Reem Yassine, Rajaa Shoukfeh, Dilara Turk, Farhan Huq, Meena Moossavi
College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan
School of Medicine, Wayne State University, Detroit, Michigan
Department of Dermatology, Wayne State University, Detroit, Michigan
See The Study

15 reviews for Nitric Oxide Boosting Age-Defiance Eye Cream

  1. Terry M

    I’ve been using the N1 o1 serum for about 6 months and super happy with the results.
    I was looking forward to trying the N1 o1 age-defiance eye cream to help with the dark area and fine lines around my eyes,
    First, the packaging is beautiful. The eye cream is rich, smooth, reduced the dark area, and small lines around my eyes.

  2. Martin W

    I like the texture, smell is very neutral, which i like, and it is filled completely to the top so be careful when taking off the lid, be ready to apply some. I have tried other N1O1 products and this is a great compliment and worth the price. after applying i could feel a slight tingling sensation, but seems to be working great to hydrate the area around my eyes. I am grateful there is a N1O1 store on amazon.

  3. Tina L.

    I actually just receive my jar about 10 day ago because I live in Taiwan and I have to have it sent to my relatives in the US and her brother brought it to Taiwan for me , so only used for one week really can’t tell a whole lot but I did notice my dark spot gotten a bit lighter and under eye bag has some improvement I believe after finishing one jar I should have much noticeable change , this is the only kind of cream with cN1O1 which has done wonderful job to our body , check it out !

  4. Karen Schwenke

    I saw almost immediate results, fine lines disappearing, dark circles gone. I will definitively purchase again.

  5. CJo

    I love this eye cream. I am getting ready to start my 2nd jar. I have tried many eye creams and I think I found the one I will be staying with as I really love it. I use it every morning and night. Not greasy. I highly recommend you try it. You won’t be disappointed.

  6. Swil75

    I will admit I was a skeptic at first but figured I’d take the chance. So it’s only been a couple weeks but have already seen a difference. While it’s not drastic yet in the first couple weeks, I can definitely tell the lines have faded and under the eyes looks firmer. Excited to see what another couple weeks does! It is expensive for a small jar but in my opinion, worth the price for something that actually works. I will be re-ordering when it’s time!

  7. Jeff Gonzales

    I am a huge fan of their serum and hoped or, more likely, assumed that the eye cream would work just as well and just as quickly. With the serum, it was only a matter of a few days before I started to notice some pretty fantastic results. A few months later, the lines on my forehead (my primary focus) are far less noticeable. 1 of my 4 lines is almost gone and another one is barely hanging on – out of spite, I’m sure. As far as the other 2, well, they are still there, but much less prominent. I admit, I’ve become a little obsessed, but couldn’t be happier with the results so far.

    On to the Eye Cream. I kinda love this stuff. It’s creamy and rich and easy to use. I’ve been using it for about 3 to 4 weeks. I have noticed some subtle changes under my eyes. Not as dramatic as using the serum on my forehead, but I like what I see and I’m not giving up now.

    I am definitely a fan.

  8. Ari

    I’ve struggled with dark circles and fine lines for years, but the Age-Defiance Eye Cream has been a game-changer. Its lightweight texture absorbs quickly without feeling heavy, making it perfect for daily use. Within just a few weeks, the area under my eyes looked noticeably brighter, and the fine lines around them started to fade. It’s amazing to finally find something that truly works—I’m beyond thrilled!

  9. Anna G.

    The Age-Defiance Eye Cream is exactly what my skin needed! The peptides in the formula really make a difference—my under-eye area feels incredibly hydrated and looks visibly firmer. Within days, I noticed a subtle lift that made my eyes look brighter and more awake. I couldn’t be happier with how refreshed and youthful my skin feels. Dr. Bryan makes the best products!

  10. Layla

    I’m amazed at how quickly the Age-Defiance Eye Cream worked for me! My under-eye puffiness was always the first thing people noticed, but within just a few days of using this cream, the swelling reduced dramatically. It’s so gentle on my skin, and the overall texture of my eye area has improved—it’s so much smoother now. It’s a little jar of magic, and I’m so happy this is available to subscription so I don’t have to run into a fear of running out!

  11. Nancy

    My eyes have never looked this refreshed! The Age-Defiance Eye Cream has an incredibly lightweight feel, so it’s perfect for wearing under makeup. Within a couple of weeks, my crow’s feet softened dramatically, and the area around my eyes now looks so much brighter. My tired eyes are finally rejuvenated, and I can’t imagine my routine without this cream—highly recommend. Five stars!!

  12. Christopher Lopez

    I never paid much attention to skincare until my wife pointed out the dark circles under my eyes were making me look exhausted all the time. As a 38-year-old who works long hours in finance, I figured it came with the territory. But after using the Age-Defiance Eye Cream for about a month, the difference is really noticeable. The dark circles have lightened significantly, and those fine lines at the corners of my eyes aren’t as prominent. What I appreciate most is how lightweight it feels—no greasy residue or weird smell. It’s become part of my morning routine, and honestly, I look more refreshed and alert. Even my colleagues have commented that I seem more rested lately.

  13. stephanie lang

    As a busy mom who’s always on the go, I started noticing the skin around my eyes looking tired and dull. Between sleepless nights and the stress of daily life, the fine lines and puffiness were getting worse. A friend recommended the Age-Defiance Eye Cream, and honestly, I wasn’t sure it would make a difference. But after using it twice a day for about six weeks, I’m amazed. The skin around my eyes looks smoother and more hydrated, and the puffiness has noticeably reduced. It’s lightweight, absorbs quickly, and fits perfectly into my skincare routine. I feel more refreshed and confident, even without makeup. This has definitely become a go-to product for me!

  14. Regina luis

    I’m a nurse so I’m constantly on my feet and working long shifts, I started noticing the effects of stress and sleepless nights on my eyes. Fine lines, puffiness, and a tired, dull look became all too common. I’ve always been fan of Dr. Bryan’s work so I finally decided to give the n1o1 eye cream a try, I didn’t expect much—but I decided to give it a shot. After using it everyday for a month, I’m blown away by the difference. The puffiness has gone down, my fine lines look softer, and my skin feels smoother and more hydrated. Now, even after night shifts, I look more awake.

  15. Suzie K.

    Best eye cream on the market. Expensive for the size but with consistent use, i feel like this really makes a difference for my under-eye bags

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