Studies
[1] Dermal Nitrite Application Enhances Global Nitric Oxide Availability: New Therapeutic Potential for Immunomodulation?
Journal of Investigative Dermatology
Maria Francisca Garcia-Saura, Bernadette O. Fernandez, Brian P. McAllister, David R. Whitlock, William W. Cruikshank, Martin Feelisch
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA
Nitroceutic LLC, Dover, Massachusetts, USA
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[2] Nitric oxide therapy for dermatologic disease
PubMed
Brandon L Adler, Adam J Friedman
Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA
Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
George Washington School of Medicine & Health Sciences, Washington, DC, USA
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[3] Nitric Oxide Signal Transduction and Its Role in Skin Sensitization
PubMed
Jong Hun Kim, Min Sik Choi
Department of Food Science and Biotechnology, and Institute for Basic Sciences, Sungshin Women’s University, Seoul 01133, Republic of Korea
Lab of Pharmacology, College of Pharmacy, Dongduk Women’s University, Seoul 02748, Republic of Korea
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[4] Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review
PubMed
Andrada Pintea, Andrei Manea, Cezara Pintea, Robert-Alexandru Vlad, Magdalena Bîrsan, Paula Antonoaea, Emöke Margit Rédai, Adriana Ciurba
Medicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania
Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures
Department of Drug Industry and Pharmaceutical Biotechnology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
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[5] Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
PubMed
Sekyoo Jeong, Seokjeong Yoon, Sungwoo Kim, Juyeon Jung, Myungho Kor, Kayoung Shin, Chaejin Lim, Hyo Sun Han, Haekwang Lee, Kyeong-Yong Park, Jinwan Kim, Hwa Jee Chung, Hyun Jung Kim
Research Division, Incospharm Corporation, Daejeon 34036, Korea
P&K Skin Research Center Company Limited, Seoul 07236, Korea
Research Division, Cha Meditech Corporation, Daejeon 34025, Korea
CHA Bio F&C, Seongnam 13488, Korea
Department of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea
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[6] A review of the efficacy of popular eye cream ingredients
PubMed
Hanin Hamie, Reem Yassine, Rajaa Shoukfeh, Dilara Turk, Farhan Huq, Meena Moossavi
College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan
School of Medicine, Wayne State University, Detroit, Michigan
Department of Dermatology, Wayne State University, Detroit, Michigan
See The Study
Terry M –
I’ve been using the N1 o1 serum for about 6 months and super happy with the results.
I was looking forward to trying the N1 o1 age-defiance eye cream to help with the dark area and fine lines around my eyes,
First, the packaging is beautiful. The eye cream is rich, smooth, reduced the dark area, and small lines around my eyes.
Martin W –
I like the texture, smell is very neutral, which i like, and it is filled completely to the top so be careful when taking off the lid, be ready to apply some. I have tried other N1O1 products and this is a great compliment and worth the price. after applying i could feel a slight tingling sensation, but seems to be working great to hydrate the area around my eyes. I am grateful there is a N1O1 store on amazon.
Tina L. –
I actually just receive my jar about 10 day ago because I live in Taiwan and I have to have it sent to my relatives in the US and her brother brought it to Taiwan for me , so only used for one week really can’t tell a whole lot but I did notice my dark spot gotten a bit lighter and under eye bag has some improvement I believe after finishing one jar I should have much noticeable change , this is the only kind of cream with cN1O1 which has done wonderful job to our body , check it out !
Karen Schwenke –
I saw almost immediate results, fine lines disappearing, dark circles gone. I will definitively purchase again.
CJo –
I love this eye cream. I am getting ready to start my 2nd jar. I have tried many eye creams and I think I found the one I will be staying with as I really love it. I use it every morning and night. Not greasy. I highly recommend you try it. You won’t be disappointed.
Swil75 –
I will admit I was a skeptic at first but figured I’d take the chance. So it’s only been a couple weeks but have already seen a difference. While it’s not drastic yet in the first couple weeks, I can definitely tell the lines have faded and under the eyes looks firmer. Excited to see what another couple weeks does! It is expensive for a small jar but in my opinion, worth the price for something that actually works. I will be re-ordering when it’s time!
Jeff Gonzales –
I am a huge fan of their serum and hoped or, more likely, assumed that the eye cream would work just as well and just as quickly. With the serum, it was only a matter of a few days before I started to notice some pretty fantastic results. A few months later, the lines on my forehead (my primary focus) are far less noticeable. 1 of my 4 lines is almost gone and another one is barely hanging on – out of spite, I’m sure. As far as the other 2, well, they are still there, but much less prominent. I admit, I’ve become a little obsessed, but couldn’t be happier with the results so far.
On to the Eye Cream. I kinda love this stuff. It’s creamy and rich and easy to use. I’ve been using it for about 3 to 4 weeks. I have noticed some subtle changes under my eyes. Not as dramatic as using the serum on my forehead, but I like what I see and I’m not giving up now.
I am definitely a fan.
Ari –
I’ve struggled with dark circles and fine lines for years, but the Age-Defiance Eye Cream has been a game-changer. Its lightweight texture absorbs quickly without feeling heavy, making it perfect for daily use. Within just a few weeks, the area under my eyes looked noticeably brighter, and the fine lines around them started to fade. It’s amazing to finally find something that truly works—I’m beyond thrilled!
Anna G. –
The Age-Defiance Eye Cream is exactly what my skin needed! The peptides in the formula really make a difference—my under-eye area feels incredibly hydrated and looks visibly firmer. Within days, I noticed a subtle lift that made my eyes look brighter and more awake. I couldn’t be happier with how refreshed and youthful my skin feels. Dr. Bryan makes the best products!
Layla –
I’m amazed at how quickly the Age-Defiance Eye Cream worked for me! My under-eye puffiness was always the first thing people noticed, but within just a few days of using this cream, the swelling reduced dramatically. It’s so gentle on my skin, and the overall texture of my eye area has improved—it’s so much smoother now. It’s a little jar of magic, and I’m so happy this is available to subscription so I don’t have to run into a fear of running out!
Nancy –
My eyes have never looked this refreshed! The Age-Defiance Eye Cream has an incredibly lightweight feel, so it’s perfect for wearing under makeup. Within a couple of weeks, my crow’s feet softened dramatically, and the area around my eyes now looks so much brighter. My tired eyes are finally rejuvenated, and I can’t imagine my routine without this cream—highly recommend. Five stars!!
Christopher Lopez –
I never paid much attention to skincare until my wife pointed out the dark circles under my eyes were making me look exhausted all the time. As a 38-year-old who works long hours in finance, I figured it came with the territory. But after using the Age-Defiance Eye Cream for about a month, the difference is really noticeable. The dark circles have lightened significantly, and those fine lines at the corners of my eyes aren’t as prominent. What I appreciate most is how lightweight it feels—no greasy residue or weird smell. It’s become part of my morning routine, and honestly, I look more refreshed and alert. Even my colleagues have commented that I seem more rested lately.
stephanie lang –
As a busy mom who’s always on the go, I started noticing the skin around my eyes looking tired and dull. Between sleepless nights and the stress of daily life, the fine lines and puffiness were getting worse. A friend recommended the Age-Defiance Eye Cream, and honestly, I wasn’t sure it would make a difference. But after using it twice a day for about six weeks, I’m amazed. The skin around my eyes looks smoother and more hydrated, and the puffiness has noticeably reduced. It’s lightweight, absorbs quickly, and fits perfectly into my skincare routine. I feel more refreshed and confident, even without makeup. This has definitely become a go-to product for me!
Regina luis –
I’m a nurse so I’m constantly on my feet and working long shifts, I started noticing the effects of stress and sleepless nights on my eyes. Fine lines, puffiness, and a tired, dull look became all too common. I’ve always been fan of Dr. Bryan’s work so I finally decided to give the n1o1 eye cream a try, I didn’t expect much—but I decided to give it a shot. After using it everyday for a month, I’m blown away by the difference. The puffiness has gone down, my fine lines look softer, and my skin feels smoother and more hydrated. Now, even after night shifts, I look more awake.
Suzie K. –
Best eye cream on the market. Expensive for the size but with consistent use, i feel like this really makes a difference for my under-eye bags