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Glycerin, sodium PCA and sodium hyaluronate are included in the formula.






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A face cream with peptides, growth factors, humectants and nourishing lipids. Finish your morning and evening skincare routine with a moisturizer designed by Dr. Nathan S. Bryan.
1.75 oz / 50 g
A face cream with peptides, growth factors, humectants and nourishing lipids. Finish your morning and evening skincare routine with a moisturizer designed by Dr. Nathan S. Bryan.
Glycerin, sodium PCA and sodium hyaluronate are included in the formula.
Grape seed oil and squalane support a soft, moisturized skin feel.
Use after the cleanser and serum on clean, dry skin.
Build your routine, step by step. Follow the directions on each current package.
Begin with clean, dry skin.
Apply the cream to the face as directed on the current package, morning and night.
Keep in a cool, dark place and use before the expiration date on the package.
Sodium nitrite, a peptide complex, growth factors including sh-oligopeptide-1, glycerin, sodium PCA, sodium hyaluronate, grape seed oil and squalane. See the complete ingredient list below.
Water, Vitis Vinifera (Grape) Seed Oil , Cetearyl Alcohol , Glyceryl Stearate SE , Squalane , Ceteareth-20 , Glycerin , Sodium Nitrite , Magnesium Aluminum Silicate , Sodium PCA , Sodium Hyaluronate , Butylene Glycol , Polyacrylamide , Palmitoyl Tripeptide-1 , Lecithin , Acetyl Glutamine , Palmitoyl tetrapeptide-7 , sh-Oligopeptide-1 , sh-Oligopeptide-2 , Arnica Montana Flower Extract , Cetyl Esters , Humulus Lupulus (Hops) Extract , sh-Polypeptide-1 , sh-Polypeptide-9 , Equisetum Hyemale Extract , sh-Polypeptide-11 , Pinus Strobus Cone Extract , Lecithin, Bacillus/Folic Acid Ferment Filtrate Extract , Hydrogenated Ethylhexyl Olivate , Hydrogenated Olive Oil Unsaponifiables , Citrus Limon (Lemon Bioflavonoids) Peel Extract , Rosmarinus Officinalis (Rosemary) Extract , C13-14 Isoparaffin , Phenoxyethanol , Cetyl Alcohol , 1,2-Hexanediol , Caprylyl Glycol , Laureth-7 , Polysorbate 20 , Carbomer , Titanium Dioxide .
View the original label images in the gallery above. Your current package is the reference for the formula and directions.
Back to the product galleryOriginal N1O1 videos for this product. Choose a video to hear the explanation and see the routine.
Watch the original N1O1 demonstration.
Watch the original N1O1 demonstration.
Dr. Nathan S. Bryan’s work focuses on nitric oxide biochemistry. Explore the formulation, follow the directions and keep learning about the science behind your routine.
Hear from N1O1
Research references linked by N1O1 for this product. Individual studies have their own designs and populations; they are provided for further reading.
4.85 / 5.0 from 13 published customer reviews.
The essentials for Age-Defiance Face Cream.
Apply morning and night on clean, dry skin.
The original product page pairs it with the Gel Cleanser, Activating Serum and Eye Cream. Let the serum absorb before layering other products.
Keep the cream in a cool, dark place and use it before the expiration date printed on the package.
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Sales, bundle pricing and new product drops, a few times a month.