Cleanse
Remove surface impurities, excess oil, sunscreen and makeup.









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A gel cleanser with alpha hydroxy acids, fruit extracts and hydrating ingredients. Use it as the first step before serum and moisturizer.
3.3 fl oz / 97.6 mL
A gel cleanser with alpha hydroxy acids, fruit extracts and hydrating ingredients. Use it as the first step before serum and moisturizer.
Remove surface impurities, excess oil, sunscreen and makeup.
The formula combines AHAs and fruit-derived ingredients for exfoliation.
Clean, dry skin is ready for the next step in the N1O1 routine.
Build your routine, step by step. Follow the directions on each current package.
Apply 2–3 pumps to damp skin.
Gently massage over the face and neck for 30–60 seconds.
Rinse thoroughly with lukewarm water and pat dry before applying serum.
An AHA blend with glycolic, lactic, citric, tartaric and malic acids, fruit extracts, glycerin, aloe and green tea. The complete ingredient list is available below.
Water, Ammonium Lauryl Sulfate , Glycerin , Hydroxyethylcellulose , Potassium Oleate, Potassium Cocoate , Glycolic Acid , Lactic Acid , Citric Acid , Tartaric Acid , Malic Acid , Passiflora Edulis Fruit Extract , Ananas Sativus (Pineapple) Fruit Extract , Vitis Vinifera (Grape) Fruit Extract , Aloe Barbadensis Leaf Juice , Algae Extract, Ascorbic Acid , Camellia Oleifera Leaf Extract , Lonicera Caprifolium (Honeysuckle) Flower Extract , Lonicera Japonica (Honeysuckle) Flower Extract , Propanediol , Cola Acuminata Seed Extract , Polysorbate 20 , Fragrance , Alcohol Denat ., Potassium Citrate, Tetrasodium EDTA
View the original label images in the gallery above. Your current package is the reference for the formula and directions.
Back to the product galleryOriginal N1O1 videos for this product. Choose a video to hear the explanation and see the routine.
Watch the original N1O1 demonstration.
Dr. Nathan S. Bryan’s work focuses on nitric oxide biochemistry. Explore the formulation, follow the directions and keep learning about the science behind your routine.
Hear from N1O1
Research references linked by N1O1 for this product. Individual studies have their own designs and populations; they are provided for further reading.
4.93 / 5.0 from 15 published customer reviews.
The essentials for Age-Defiance Gel Cleanser.
Use the cleanser first, then pat the skin dry before applying the N1O1 serum. Follow with your moisturizer and eye cream.
Apply 2–3 pumps to damp skin, massage gently for 30–60 seconds, then rinse thoroughly. Use morning and night according to the current bottle.
Yes. The original formula lists alpha hydroxy acids and fruit-derived ingredients. Review the complete formula if your skin is sensitive to specific ingredients.
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Read shipping & return terms1 bottle$39.98
Sales, bundle pricing and new product drops, a few times a month.