Skin Care
Nitric Oxide Activating Age-Defiance Serum
The N1O1 dual-chamber serum keeps the two formulas separate until use. Mix them in your palm, then apply to the face and neck.
$95.98 Subscribe, save 20%
$119.98 one-time
The N1O1 collection
Cleansers, serum, face and eye creams, and complete systems. Explore the N1O1 skincare range and build your routine one step at a time.
Skin Care
The N1O1 dual-chamber serum keeps the two formulas separate until use. Mix them in your palm, then apply to the face and neck.
$95.98 Subscribe, save 20%
$119.98 one-time
Skin Care
Bring Age-Defiance Gel Cleanser, Age-Defiance Activating Serum, Age-Defiance Eye Cream and Age-Defiance Face Cream together in one N1O1 b...
$242.93 Subscribe, save 10%
$269.92 one-time was $299.92
Skin Care
A gel cleanser with alpha hydroxy acids, fruit extracts and hydrating ingredients. Use it as the first step before serum and moisturizer.
$31.98 Subscribe, save 20%
$39.98 one-time
Skin Care
An eye cream formulated with a peptide complex, ceramides and hydrating ingredients. Gently pat a small amount around the eyes as part of...
$47.98 Subscribe, save 20%
$59.98 one-time
Skin Care
A face cream with peptides, growth factors, humectants and nourishing lipids. Finish your morning and evening skincare routine with a moi...
$63.98 Subscribe, save 20%
$79.98 one-time
Skin Care
Bring Age-Defiance Activating Serum and Age-Defiance Eye Cream together in one N1O1 bundle.
$145.76 Subscribe, save 10%
$161.96 one-time was $179.96
Skin Care
Bring Breath of Life Toothpaste, N1o1 Nitric Oxide Lozenges, N.O. Beetz, Age-Defiance Gel Cleanser, Age-Defiance Activating Serum, Age-De...
$409.37 was $454.87
Bundles
Bring N1o1 Nitric Oxide Lozenges, N.O. Beetz, Breath of Life Toothpaste and Age-Defiance Activating Serum together in one N1O1 bundle.
$247.43 was $274.93
Bundles
Bring Age-Defiance Gel Cleanser and Age-Defiance Eye Cream together in one N1O1 bundle.
$80.96 Subscribe, save 10%
$89.96 one-time was $99.96
Bundles
Bring Age-Defiance Gel Cleanser and Age-Defiance Activating Serum together in one N1O1 bundle.
$129.56 Subscribe, save 10%
$143.96 one-time was $159.96
Bundles
Bring N1o1 Nitric Oxide Lozenges and Age-Defiance Activating Serum together in one N1O1 bundle.
$145.76 Subscribe, save 10%
$161.96 one-time was $179.96
Your skincare questions, answered
From the first cleanse to the final cream.
Start with the step your routine needs. The collection includes a cleanser, serum, face cream, and eye cream, plus systems and combinations.
Explore the cleanser
Age-Defiance Gel Cleanser
The serum is a separate step from cleansing and moisturizing. Its product page explains the ingredients and application directions so you can fit it into your existing routine.
Explore the serum
Nitric Oxide Activating Age-Defiance Serum
They are separate products for different areas. Compare their ingredients and follow each product’s application directions.
Explore face cream
Nitric Oxide Age-Defiance Face Cream
The eye cream has its own product page, ingredients, and directions. The Bright Eyes collection is another option to compare if you want a combination.
Explore eye cream
Nitric Oxide Boosting Age-Defiance Eye Cream
The skincare system brings together several steps. Check its product page for the exact included products and instructions rather than assuming every skincare item is included.
See the skincare system
N1o1 Nitric Oxide Age-Defiance Skincare System
Compare what you already own with the contents of the bundle. Choose a combination that adds the steps you want, rather than duplicating products in your routine.
Explore Bright Eyes
N1o1 Nitric Oxide Age-Defiance Bright Eyes Collection
Build around the products your routine actually needs.
01 · Cleanse
Your cleansing step
Follow the cleanser’s application directions
Explore this option: Age-Defiance Gel Cleanser
02 · Serum
A dedicated serum step
Compare ingredients and application instructions
Explore this option: Nitric Oxide Activating Serum
03 · Moisturize
Choose for the area you apply it
Use each cream according to its own directions
Explore this option: Face & eye creamsMeet the formulator
Dr. Bryan formulates the N1O1 lineup himself. Hear the brand story, then explore the science and directions behind the products you choose.
Meet Dr. BryanA skincare routine is easier to understand when every product has a role. The N1O1 range separates cleansing, serum, face cream, and eye cream, so you can explore one step or a complete system.
Check the ingredient list and directions on each product page, especially when combining N1O1 with products you already use. Bundles are a way to buy products together; the individual application directions still matter.
A little more clarity
The collection includes the N1O1 cleanser, serum, face cream, eye cream, skincare system, and combinations that include skincare products.
You can shop individual products. Choose the steps you want to add and compare the system contents if you prefer a combination.
Open the product page for its application instructions. Follow those directions when building your routine.
They are listed as separate products. Use each for the area and application described in its directions.
Each skincare product has its own ingredient information on its product page. Do not assume one formula represents the entire collection.
Review the ingredients and product directions before use. If you have a skin condition or a concern about your existing routine, ask your healthcare professional.
Still have a question?
Ask the N1O1 teamExplore the range, read the details, and choose the routine that fits.