Comprehensive Skin Revitalization

N1O1 nitric oxide nitric oxide nitric oxide signaling molecule

N1O1 nitric oxide nitric oxide Dr. Nathan Bryan

N1O1 nitric oxide nitric oxide signaling molecule

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Build a four-step routine with Age-Defiance Gel Cleanser, Activating Serum, Eye Cream and Face Cream.

4 steps · cleanser, serum, eye cream & face cream

Created by Dr. Nathan Bryan
4-product routine
Directions for every step

Your N1O1 skincare routine, step by step.

The N1O1 Age-Defiance Skincare System brings four existing products together in one bundle. Start with the Gel Cleanser, mix the dual-chamber Activating Serum when you apply it, then use the Eye Cream and Face Cream according to their individual directions. Explore every included product and its formula below.

Cleanse and prepare

Begin with the Gel Cleanser, then pat the skin dry before applying serum.

Mix at application

The Activating Serum keeps its two formulas separate until you dispense and mix them.

Complete the routine

Use the Eye Cream for the eye area and Face Cream for facial hydration, following each product’s label.

N1o1 Nitric Oxide Age-Defiance Skincare System

Everything in your collection.

A closer look at each product included in this routine.

Make each step count.

Build your routine, step by step. Follow the directions on each current package.

Age-Defiance Gel Cleanser

Apply 2–3 pumps to damp skin.
Gently massage over the face and neck for 30–60 seconds.
Rinse thoroughly with lukewarm water and pat dry before applying serum.

See complete product details

Nitric Oxide Activating Age-Defiance Serum

On clean, dry skin, dispense one pump from each chamber into your palm.
Mix the two formulas together before applying.
Apply evenly to the face and neck, morning and night. Allow 1–2 minutes to absorb before layering other products.

See complete product details

Nitric Oxide Boosting Age-Defiance Eye Cream

Start with clean, dry skin around the eyes.
Apply a small amount and gently pat with your ring finger until absorbed.
Use morning and night as directed. Store in a cool, dark place.

See complete product details

Nitric Oxide Age-Defiance Face Cream

Begin with clean, dry skin.
Apply the cream to the face as directed on the current package, morning and night.
Keep in a cool, dark place and use before the expiration date on the package.

See complete product details

Inside the formulation.

Each product in this bundle has its own formula. Open the included product pages below for ingredients and current label information.

Where to find each formula

Read the product label

View the original label images in the gallery above. Your current package is the reference for the formula and directions.

Back to the product gallery

Developed by the scientist behind N1O1.

Dr. Nathan S. Bryan’s work focuses on nitric oxide biochemistry. Explore the formulation, follow the directions and keep learning about the science behind your routine.

Meet Dr. Bryan

Dr. Nathan S. Bryan, the scientist behind N1O1

Go deeper into the science.

Research references linked by N1O1 for this product. Individual studies have their own designs and populations; they are provided for further reading.

A Novel Combination Therapy in Aesthetic and Reconstructive Surgery: Sea Salt Exfoliation, Cavitating Ultrasound, and High Intensity Multiwavelength LED Treatment: (SaltFacial)

What customers report.

4.91 / 5.0 from 11 published customer reviews.

Questions before you start?

The essentials for Comprehensive Skin Revitalization.

Which products are included?

Age-Defiance Gel Cleanser, Age-Defiance Activating Serum, Age-Defiance Eye Cream and Age-Defiance Face Cream. The included-product cards link to each product’s full details.

How do I apply the Activating Serum?

On clean, dry skin, dispense one pump from each chamber into your palm. Mix the two formulas, then apply to the face and neck. Allow 1–2 minutes before layering other products. Follow the current package directions.

Are these different formulas from the individual products?

No. The system combines the four listed products; it does not create a separate combined formulation.

Can I shop the products individually?

Yes. Open an included-product card to see its individual product page and available purchase options.

Where can I find ingredients and directions?

The routine guide summarizes how to use each product. Follow the formula links for each complete ingredient list and use the current package as your reference.

How do subscriptions work?

Choose Subscribe in the buy box to see the current price and delivery schedule. The selling plan and selected quantity are included when you add the product to your cart. Review the subscription terms at checkout.

What about shipping and returns?

Free shipping applies to orders over $75 in the continental US. Read the current policy for eligibility, timing and return instructions.

Read shipping & return terms

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

1 bundle$269.92

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I started these a month ago after my sister sent me a bottle. I have MS and have had many issues of pressure sores due to being paralyzed. My sores have healed very fast and hoping they continue. My husband also takes them as he has cancer and being on chemo; he has had no bad reaction to his treatments. These are a winner at our home.

I really appreciate the deep research backed behind this product (I also have his book. Still need to read). I've been a consistent customer for WELL over a year now but I may have to stop. Things are getting so expensive that I'm having to find a more affordable product. Also, there are SO MANY 'Other Ingredients' that I didn't realize until recently (not sure how I missed this). There's probably a reason for that. I don't like the citric acid, natural flavors, stevia AND monk fruit (rather than just one), ,,, I don't know. I've lost trust with the American food, preservative, and supplementation systems. I've struggled with health issues and wonder how much of it has to do with these 'fillers' that people say are 'reasonably safe'.

I think this tooth paste is excellent and my teeth feels happily cleaned I’m in my eighties and have pain in my hands and it’s so difficult to squeeze maybe the tube could be made softer for us older folks 😊

I have been using the N1o1 and I can tell the difference in my energy level. I can also tell that my cholesterol numbers are lower.

I've been giving this to my father who has emphasema and an oxygen saturation count of 89 after having one lozenger he's oxygen saturation goes up to 98.to 99 for about 6 to 8 hours before needing another longer
It has helped improve his breathing is not short of breath or wheezing while having lozenger
I take them myself being a smoker I noticed I'm shorter breath when exercising if I have one before exercising I'm not as short of breath and dizzy at the end of exercises
My father's lung specialist Brian Jarvis thought there are waste of time until he seen the results on his pulse oximeter and the fact that my father was not sure of breath he recommended that I keep giving him to my father and he was gonna do some more research to see about recommending some to his other patients

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Comprehensive Skin Revitalization