N1o1 Nitric Oxide Lozenges

Nitric oxide, released as it dissolves. A daily lozenge formulated by Dr. Nathan S. Bryan to support circulation, energy, and everyday vitality.

$59.98

60 lozenges · Take 2 daily

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1 bottle · $59.98 today

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Meet the people talking N1O1

  • Formulated by Dr. Nathan Bryan
  • Vegan
  • Gluten Free
  • Non-GMO

Creators and clinicians.

The N1O1 lozenge, explained by its founders and shared by the people who use it.

Formulated by the scientist behind N1O1.

Dr. Nathan S. Bryan’s work focuses on nitric oxide biochemistry and its role in human health. The lozenge brings that focus into a dissolving format, designed to release nitric oxide in the mouth.

Explore the formulation, see the complete label, and hear the instructions directly from the people who created it. Understanding what you take should be part of your daily routine, not an afterthought.

Hear from Dr. Bryan
Dr. Nathan Bryan holding N1O1 lozenges

Watch. Learn. Make it a routine.

The way you take a dissolving lozenge matters. These original N1O1 demonstrations walk through using the product, with Dr. Nathan Bryan and Susan Shaffer, President and Co-Founder. Watch either video before your first serving, and use the directions on your current bottle as your reference.

Dr. Nathan Bryan

The formulation, explained by its founder.

Susan Shaffer

A practical guide to taking your lozenge.

A small molecule. An essential role.

Nitric oxide is a signaling molecule involved in blood-vessel relaxation and healthy circulation. Blood flow carries oxygen and nutrients throughout the body, connecting everyday movement, stamina, and cardiovascular wellness.

N1O1 lozenge bottle on a blue display

Support healthy circulation

N1O1 lozenges are formulated to support nitric oxide levels and healthy blood flow. The product releases nitric oxide as the lozenge dissolves, placing the delivery format at the center of the formulation.

Support everyday vitality

The N1O1 formula supports energy, stamina, and cardiovascular wellness. It fits into a broader routine that includes movement, nourishment, and rest. Individual experiences vary; the product is not a substitute for medical care.

A dissolving format

This is a lozenge rather than a capsule. Letting it dissolve slowly in the mouth is part of the intended use. You can see the bottle, the back label, and the original product information in the gallery above.

Know what you are taking

Each serving is two lozenges. The label lists vitamin C, magnesium, and the N1O1 proprietary blend, alongside the complete other-ingredient list. The facts panel below reproduces those amounts so you can review the formula before purchasing.

60

Lozenges per bottle

Each bottle holds 60 lozenges, or 30 servings of two lozenges. How long a bottle lasts depends on the directions you follow. N1O1 recommends one lozenge twice daily, 12 hours apart.

2

Lozenges per serving

A measured serving makes it straightforward to read the amounts on the label. Review the current bottle directions and discuss use with your healthcare professional if you have questions about your individual routine.

5-6

Minutes to dissolve

N1O1 describes a typical dissolution time of approximately 5-6 minutes. Move the lozenge slowly around your mouth. The founder and president demonstrate the technique in the videos above, so you can return to the instructions whenever you need a refresher.

Let it dissolve. Give it time.

N1O1 recommends one lozenge twice a day, 12 hours apart. Move it slowly around the mouth as it dissolves, which the N1O1 guide describes as taking approximately 5-6 minutes. Follow the directions on your current product label.

01 · Start with one

Two lozenges, one in the morning and one 12 hours later, make one serving. Keep your bottle somewhere that makes the routine easy to remember, and check its directions before your first use.

02 · Dissolve slowly

Move the lozenge around your mouth rather than leaving it in one place. The two instructional videos above show the intended technique.

03 · Keep it consistent

Use according to the label. If you notice mouth irritation or have concerns about combining supplements or medications, stop and ask a healthcare professional before continuing.

Inside the formulation.

See the form and amount of the ingredients declared on the product label. The proprietary blend is listed as a combined amount; individual quantities within that blend are not disclosed. This explorer is a guide to the label, followed by the complete Supplement Facts panel.

Vitamin C · 328 mg per serving

Provided as magnesium ascorbate. A 2-lozenge serving provides 364% of the Daily Value (164 mg, 182% per lozenge). Vitamin C is included as part of this formulation; the complete panel below also shows the magnesium contribution and the proprietary blend.

The complete label. Nothing tucked away.

Review the serving size, declared amounts, and Daily Values before choosing a product. These figures are the per-lozenge amounts from the N1O1 bottle label, shown for a 2-lozenge serving. The original label is also in the gallery, with a zoom control for a closer look.

Other ingredients: Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltodextrin, Stearic Acid, Vegetable Stearate, Food Starch - Modified, Starch, Silica, Stevia, Citric Acid, Monk Fruit Extract.

Always refer to the label on the bottle you receive for the most current product information.

Supplement Facts

Serving size: 2 lozenges
Servings per container: 30

NutrientAmount% DV
Vitamin C
from magnesium ascorbate
328 mg364%
Magnesium
from magnesium ascorbate
25.6 mg6%
N1O1 proprietary blend
Magnesium ascorbate, sodium nitrite
440 mg*

* Daily Value not established.

Amounts are per 2-lozenge serving. Each lozenge provides 164 mg vitamin C (182% DV), 12.8 mg magnesium (3% DV) and 220 mg N1O1 proprietary blend.

Choose the format that fits.

N1O1 offers dissolving lozenges and a beet powder drink. They have different formats, ingredient lists, and directions. Start by choosing how you prefer to take a supplement, then read the specific label. A similar purpose does not make two formulations interchangeable.

What to compareN1O1 lozengesBeet powder drink
FormatDissolves in the mouthMixed into water
PreparationTwo lozenges per servingFollow the drink’s own label
Ingredient referenceComplete facts aboveSeparate formula and facts

Follow the science.

N1O1 brings together research on nitric oxide, oral bacteria, and nutrition. These resources provide context for the science behind the category. A research paper is not automatically a clinical trial of the current retail product, and study populations and methods matter when interpreting a result.

Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria

Read on PubMed ↗

Experiences from N1O1 customers.

4.63 / 5.0 from 41 published customer reviews.

Science you can keep exploring.

Dr. Nathan S. Bryan is the founder behind N1O1’s nitric oxide formulation. His published work explores nitric oxide biochemistry, the oral microbiome, and nutritional approaches to nitric oxide availability. N1O1 brings together his instructional videos, research references, and books.

Use the videos on this page to understand the lozenge, and the study links to go deeper into the underlying science. Keeping the formula, directions, and references together makes it easier to ask informed questions and decide whether this format fits your routine.

Returns, made clear.

Review the store’s shipping and return terms before ordering. Eligibility, timing, and return instructions are set out in the policy. If something is not right with your order, contact the store with your order details so the team can guide you through the next step.

Keep your order details

Your order number helps the team find the purchase and answer questions.

Contact the store

Ask about eligibility and instructions before sending a product back.

Follow the policy

Read the applicable terms for shipping, returns, and refunds.

Read shipping and return terms

Explore the rest of your routine.

Stock up on your daily lozenges or explore another format.

Questions before you start?

The essentials for your daily lozenge routine. The current product label is your reference for ingredients and directions; a healthcare professional can help with questions about your particular health circumstances.

How do the lozenges work?

N1O1 lozenges are designed to release nitric oxide as they dissolve in the mouth. Nitric oxide plays a role in blood-vessel relaxation and healthy circulation. The format and directions are part of the formulation, so review the demonstrations before your first use.

How should I take a lozenge?

N1O1 recommends letting one lozenge dissolve slowly while moving it around the mouth. It describes a dissolution time of approximately 5-6 minutes and recommends use twice daily, 12 hours apart. Follow the directions on your current bottle.

What if I notice mouth sensitivity?

The N1O1 FAQ discusses mouth sensitivity. If you experience irritation, stop use and ask a healthcare professional for advice. Do not continue through persistent discomfort. The store can also help with questions about the product and its return policy.

Can I combine it with other supplements?

The N1O1 FAQ discusses using lozenges alongside other supplements, including the beet powder drink. Because products, medications, and individual circumstances differ, ask your healthcare professional about your complete routine before combining them.

Where can I see all the ingredients?

The complete Supplement Facts panel and other-ingredient list are above. You can also zoom into the original label image in the product gallery. One serving is two lozenges, and the bottle contains 30 servings (60 lozenges).

How many bottles can I order?

For one-time purchases, choose 1 bottle, 2 bottles at 10% off, or 4 bottles: buy 3, get 1 free. Select Subscribe in the buy box to see subscription prices and delivery schedules.

Where do the reviews come from?

These are customer reviews originally submitted to N1O1. The review list, rating, and count come from the published reviews for this product in Judge.me.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

1 bottle · One-time$59.98

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