Instagram Linkedin Facebook

Cardiosmile – The worlds FIRST N.O. boosting toothpaste!

N1o1 -
User
Nitric Oxide Anti-Aging Bundle
Nitric Oxide Anti-Aging Bundle - Image 2
Nitric Oxide Anti-Aging Bundle - Image 3
Nitric Oxide Anti-Aging Bundle - Image 4
Nitric Oxide Anti-Aging Bundle - Image 5
Nitric Oxide Anti-Aging Bundle - Image 6

I used N1o1 for three months and my skin never looked better. Foolishly I stopped. Within two days, I noticed my skin texture had changed and the radiance of my skin became dull again. I started N1o1 again and my skin looks great.

— Mary T

Nitric Oxide Anti-Aging Bundle

(8 customer reviews)

Nitric Oxide Activating Age-Defiance Serum + Gel Cleanser

Still not seeing results from your skincare routine? Time to upgrade. The N1o1 Age-Defiance Gel Cleanser and Nitric Oxide Activating Serum are designed to work in perfect harmony, addressing aging skin at its core by enhancing nitric oxide production. The outcome? Firmer, smoother, and more youthful skin—all backed by Nobel Prize-winning science.

  • Visibly firmer, smoother skin
  • Revived glow & elasticity
  • Boosted circulation & oxygen flow
  • Protection from oxidative stress

Why Subscribe?

  • Price-locked at $143.96
  • Pause or cancel anytime
  • 89% of customers subscribe for long-term results

$143.96 — available on subscription

🚚 Free Shipping for Orders Above $300

Doctor Formulated & Vegan

Free Shipping for $300+

60-Day Guarantee

100% Satisfaction Guarantee

Try the bundle for 60 days, risk-free! Not satisfied with your results? It’s on us!

N1o1 Nitric Oxide Serum Cleanser Bundle

What’s Inside the Bundle?

N1O1 Nitric Oxide Serum Antioxidants Wrinkles Skin Tone Clarity

Age-Defiance Serum (1 fl oz / 30 ml)
Nitric Oxide + Vitamin C = Collagen-Boosting Power

Age Defiance Gel Cleanser Small

Age-Defiance Gel Cleanser (3.3 oz)
AHAs + Antioxidants + Nitric Oxide Pathway Activation

  • Stimulates collagen & elastin production
  • Smooths wrinkles, improves texture
  • Absorbs fast, non-greasy finish
  • Built on Nobel Prize-Winning Nitric Oxide technology
Reverse Visible Signs of Aging Now
product logos 1 1

Your N1o1 Anti-Aging Protocol

Age Defiance Gel Cleanser Small

STEP 1:

Age-Defiance Gel Cleanser
– Clean, Prep, Prime

  • Apply to damp skin AM & PM
  • Massage gently until foam forms

    • * Pro tip: For a deeper, more refreshing cleanse and exfoliation, let the product sit on your skin a bit longer than usual. "I like to apply it before hopping in the shower and rinsing it off at the end. This provides gentle yet effective exfoliation without irritating my skin." - Susan Shaffer, N1o1 President

  • Rinse thoroughly

N1O1 Nitric Oxide Serum Antioxidants Wrinkles Skin Tone Clarity Texture

STEP 2:

Nitric Oxide Activating Serum
– Repair, Rejuvenate, Rebuild

  • Apply a single pump from each chamber to the palm of your hand, mix together and apply to the entire face and neck.
  • Allow to fully absorb 1-2 minutes before applying anything else.
  • Continue as a daily routine, applying morning and night to a clean face.

NOTE: Within a few seconds your face may turn a slight pink due to an increase in Nitric Oxide. This may last up to 5 minutes.

Before & After

Lack of Nitric Oxide: The Real Reason Your Skin Looks Older Than It Should

Aging skin isn’t just about time — it’s about declining Nitric Oxide levels. By age 40, your body produces up to 50% less Nitric Oxide, a molecule essential for cellular communication, blood flow, collagen synthesis, and detoxification. That means:

  • Slower skin regeneration
  • Loss of firmness
  • More wrinkles and discoloration
  • Loss of elasticity and decrease in collagen production


Solution? Biohack it at a cellular level. The N1o1 Anti-Aging Bundle reactivates your skin’s youth code with Nitric Oxide-enhancing actives, growth factors, and clean botanicals — for long-term, visible results.

n1o1 nitric oxide - before after - decreased acne
n1o1 nitric oxide - before after - decreased age spots
n1o1 nitric oxide - before after - rejuventates skin

Nitric Oxide Is Essential

Why the Nitric Oxide Anti-Aging Bundle is Essential for Your Skin

The N1o1 Gel Cleanser and Age-Defiance Serum work in synergy with your body’s natural processes to revive Nitric Oxide production—restoring firmness, radiance, and resilience from the inside out.

N1o1 nitric oxide symbol

Synergistic Formulas

The cleanser preps your skin, the serum repairs it. Together they deliver maximum Nitric Oxide activation.

N1o1 skin symbol

Targeted Anti-Aging

Supports memory, focus, and cognitive clarity by optimizing your Nitric Oxide levels.

lab icon

Backed by Biochemistry

Created by Dr. Nathan S. Bryan, world-renowned Nitric Oxide researcher.

Image gp h full 28

Biohacker Approved

Promotes healthy blood pressure, circulation, and overall cardiovascular function.

N1o1 science meets simplicity

Science Meets Simplicity

Clean, effective, non-toxic formulas that just work.

N1o1 long term symbol

Long-Term Results

Not a quick fix. A proven routine for sustained, visible skin improvement.

Achieve Radiant Skin Today!

Ingredients

OUR KEY INGREDIENTS

The Science Behind the Results

Together, these powerhouse ingredients fuel Nitric Oxide production, stimulate collagen and elastin, protect against environmental damage, and accelerate skin cell renewal—giving your skin the strength, clarity, and glow it deserves.

N1O1 Nitric Oxide Serum Antioxidants Wrinkles Skin Tone Clarity
Vitamin C Ascorbic Acid

Vitamin C (Ascorbic Acid)

A powerful antioxidant known for its brightening and anti-aging properties.

Polysorbate 20 transparent

Polysorbate 20

A versatile skincare ingredient that emulsifies oil and water.

220 MG N1O1 Proprietary Blend

d-Tocopheryl Acetate

Form of Vitamin E used as an antioxidant in skincare and cosmetic products.

Age Defiance Gel Cleanser Small
Pineapple Fruit

Pineapple Fruit Extract

Gently exfoliates dead skin cells

Aloe Vera

Aloe Vera

Soothes and hydrates deeply

Vitamin C Ascorbic Acid

Vitamin C (Ascorbic Acid)

Brightens tone and boosts collagen

AHAs Fruit Acids

AHAs (Fruit Acids)

Increase cell turnover and smooth texture

Full Ingredients List

FAQs

What is Nitric Oxide?

Nitric Oxide, a Nobel Prize-winning discovery, plays a vital role in promoting cardiovascular and skin health. We are all born with this remarkable molecule that helps relax and expand blood vessels, enhancing circulation, oxygen delivery, and nutrient absorption. By improving blood flow, it supports overall cardiovascular function while nourishing skin cells for healthier, more vibrant skin.

Nitric oxide is naturally present in our bodies from birth, but its production declines with age, contributing to visible signs of skin aging like wrinkles, dark spots, fine lines, and reduced skin elasticity. Restoring Nitric Oxide levels can directly address these issues and slow down the signs of aging.
  • Stimulates collagen production for firmer, smoother skin
  • Enhances oxygen and hydration delivery to skin cells
  • Improves overall skin tone, texture, and clarity
  • Reduces the appearance of wrinkles, dark spots, and fine lines

Backed by 20 years of research and proven in clinical studies, N1o1 Anti-Aging Serum replenishes Nitric Oxide levels in your skin. Its unique formula works immediately, helping you achieve youthful, radiant skin while addressing the root causes of aging.

The N1o1 Age-Defying Gel Cleanser helps by gently cleansing the skin using natural fruit, flower, and plant extracts. Its Alpha-Hydroxy Acid (AHA) blend promotes cell turnover and oxygenates skin cells, while Vitamin C and Green Tea provide antioxidant protection and brighten the complexion. Soothing ingredients like Aloe Vera, Algae Extract, and Kola Nut Extract calm and nourish the skin, leaving it refreshed and radiant. It pairs perfectly with the N1o1 anti-aging serum, face cream, and eye cream for enhanced results.

The time it takes to see results can vary depending on individual skin type and concerns. However, many users have reported visible improvements in their skin’s texture, tone, and overall appearance within a few weeks of consistent use. With continuous use, the N1o1 Nitric Oxide Serum and Age-Defiance Gel Cleanser can help achieve brighter, smoother, and radiant looking skin. So don’t be discouraged if you don’t see immediate changes – give it time for the natural ingredients to work their magic! Consistency is key when it comes to proper skincare. 

About Dr. Bryan

About Dr Nathan Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

Image gp h full 41

A Pioneer in Nitric Oxide Science

With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

Image gp h full 42

Clinically Backed & Scientifically Proven

His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 Nitric Oxide Lozenges you’re about to experience.

Image gp h full 43

On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

Clinical Studies

 

[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
Annals of Plastic  & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF

[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF

[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF

8 reviews for Nitric Oxide Anti-Aging Bundle

  1. Vincent –

    My wife loves this bundle. I purchased this as a gift and she has since replaced her old skin cleanser. She raves how well it works.

  2. Greg –

    I’ve been using the Nitric Oxide Anti‑Aging Bundle for about six weeks now, and I’m genuinely impressed by the results. Each part of this trio works in harmony to deliver a full anti‑aging skincare and wellness routine.

  3. David –

    I’ve been using both products for a year now, and I’ve noticed a significant improvement; my skin looks noticeably brighter and tighter. It’s rare to find something that delivers on both performance and anti-aging benefits, but this product does. I’m 52, and people think I’m in my 30s.

  4. Lediane –

    After consistently using both products for the past three month, I can honestly say they’ve transformed my skin and overall vitality. My complexion feels firmer, smoother, and more radiant—and I’m constantly getting compliments on how youthful I look.

  5. Simon –

    This bundle is fantastic! The combination of both products has worked wonders on my skin. I truly cannot recommend it enough!

  6. Veronica –

    What a pair! I have struggles to find a cleanser that cleans, but is gentle to my skin. I love how my skin feels with these two products. Both are game changers.

  7. Denise –

    Incredible! I can tell a difference with my skin. I have gotten compliments and asked what treatment I got?! I am excited to share that I was able to use these products at home with great ease & success. I love the cleanser and serum!

  8. S. Lee –

    These two products are absolute essentials for me. The age-defiance gel cleanser provides such a gentle, refreshing cleanse, and the nitric oxide serum is truly a game-changer—I can’t go without it! Whenever I run out, the difference in my skin is impossible to ignore.. I’m so happy these are now available in 1 convenient subscription!

Add a review

Your email address will not be published. Required fields are marked *

AS SEEN IN

Limited Time Offer

Unlock Visibly Younger, Firmer, More Radiant Skin

With the N1o1 Nitric Oxide Anti-Aging Bundle, you’re not just masking aging — you’re reversing its cellular signals.

  • Rebuilds collagen, boosts glow, reduces wrinkles
  • Powered by Nitric Oxide – the anti-aging molecule
  • Clinically formulated by Dr. Nathan S. Bryan
Try It Risk-Free – Get Yours Today!

Loved by 10,000+ CUSTOMERS Across the U.S

Real Customers, Real Results

Javier G.
Honestly, I have been taking these over the last few months and my cardiovascular health has improved significantly. I have been able to run farther and longer. Have recommended these to others given their effectiveness.
I also have noticed my blood pressure overtime dropping a few points, which has been positive.
These really do seem to make a difference if taken regularly.
  • Improved Cardiovascular Health
Carl P.
N.O. Beetz taste pretty good and I feel better the longer I use it. It is east to add to a protein shake or mix up in a water bottle.
Shake it good and it blends really quickly. No chunks even without a mixing ball in your water bottle. Very happy with this.
  • Enhanced Mood & Energy
K J Spring
Amazing Supplements!

This Nitric Oxide Lozenges are simply wonderful, along with a great magnesium and potassium supplement, it helps me regulate my blood pressure without any medication and the energy I get from taking this great too!
  • Blood Pressure Regulation
Ray Rusin
One of the few products based on clinical studies supporting how the body actually supports NO production.
These tabs utilize the oral pathway and highlights the importance of mouth biome.
  • Scientifically Backed Ingredients
Romy S.
Heard about this product from Dr. Nathan Bryan’s YouTube channel. Flavor is great, just started taking it and already feeling the benefits and love that I can replace an expensive energy drink everyday with something that’s good for your heart health and gives you a boost.
  • Energy Boost & Flavor
Carrie R.
I started using this based on a recommendation from my functional medicine doctor when my blood pressure was too high. Watched a bunch of Nathan Bryan’s videos so I could understand what I was taking and yep, this stuff works. My energy levels are noticeably higher and I can almost literally feel blood hitting parts of my body that maybe were not getting adequate blood flow. I’ve been feeling really sluggish lately and I feel like I can get up and run at any time. Eager to see how this impacts my performance at the gym.
  • Energy Boost & Blood Pressure Regulation
Zell Q.

LOVE IT!!



Finally, a formula from an expert with over 30 years research focused on Nitric Oxide this critical health supplement! YAH!! Personally, I’ve only been investing in supplements this year manufactured by/ with the decades gurus who have studied them.

  • Scientifically Backed Ingredients
Better Health Starts Here

Our 100% Satisfaction Guarantee—Risk-Free!

We’re so confident that our Nitric Oxide Anti-Aging Bundle will boost your energy, improve circulation, and support your heart and brain health, that we offer a no-questions-asked, 60-day money-back guarantee on every regular purchase.



If you don’t experience the benefits or are simply not satisfied for any reason, return your purchase within 60 days, and we’ll refund your full order—guaranteed. No hassle. No stress.

DON’T MISS OUT

Join The Thousands Already Loving Their Nitric Oxide Solutions!

  • Clinically Backed & Scientifically Proven
  • Full Support for Your Overall Health
  • For Men & Women of All Ages
For a limited time, get the full bundle for just $143.96!
Try It Risk-Free – Get Yours Today!

Customer

Resources
Quicklinks
Products
Subscribe Now

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

By purchasing N1o1 products, the buyer agrees that the products are for personal use or use by the purchaser only and may not be resold, redistributed, or exported. Unauthorized resale or distribution may lead to legal action, including but not limited to injunctions, seizure of products, and damages. N1o1 enforces its rights against unauthorized resale activities vigorously and will take legal action to protect its intellectual property to the fullest extent of the law.

All company brand names, and logos of N1o1 & Pneuma Nitric Oxide LLC are trademarks or registered trademarks of Pneuma Nitric Oxide LLC or its affiliates. Unauthorized use is strictly prohibited.

Instagram Linkedin Facebook