Dr. Nathan Bryan Ph.D.
International Leader in Molecular Medicine. Founder of Bryan Therapeutics,Inc., Nitric Oxide Innovations, LLC, N1O1.com, and Bryan Nitriceuticals (NO2U.com)
Dr Nathan Bryan has been involved in nitric oxide research for the past 18 years and has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in many chronic diseases. Dr. Bryan has published a number of highly cited papers and authored or edited 6 books.
Dr Nathan Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He was the first to demonstrate and discover an endocrine function of nitric oxide via the formation of S-nitrosoglutathione and inorganic nitrite.
This technology is now validated in six published clinical trials. He is also a successful entrepreneur who has commercialized his nitric oxide technology through the formation of N1O1 (formerly Pneuma Nitric Oxide), who’s products can be found here on n1o1.com, no2u.com, and Amazon.
Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research. He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute. After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology.
Academic Education
The University of Texas at Austin
Jan 1994 – May 1997
Bachelor of Science in Biochemistry
Mentor: Jon Robertus, Ph.D.
Undergraduate research in protein purification and over-expression in bacteria
LSU School of Medicine in Shreveport
Aug 2000 – July 2004
Doctor of Philosophy
Department of Molecular and Cellular Physiology
Mentor/Advisor: Martin Feelisch, Ph.D.
Dissertation topic: Formation and physiological significance of blood and tissue nitros(yl)ation products.
Boston University School of Medicine
Whitaker Cardiovascular Institute
Department of Medicine
July 2004 – May 2006
Ruth L. Kirschstein Post-doctoral fellow
The role of nitrite as a biologically active molecule in physiology
Professional Positions
Graduate Asst.
(08/00-05/01)
LSUHSC
Dept of Molecular & Cellular Physiology, Shreveport, LA
Doctoral Candidate
(05/01-05/04)
LSUHSC
Dept of Molecular & Cellular Physiology, Shreveport, LA
Kirschstein Fellow
(06/04-05/06)
Boston University School of Medicine
Whitaker Cardiovascular Institute – Department of Medicine
Instructor
(06/06-05/07)
The University of Texas Health Science
Center at Houston, Institute of Molecular Medicine
Asst. Professor
(05/07- 08/14 )
The University of Texas Health Science Center at Houston Institute of Molecular Medicine
Adjunct Professor
(10/14 – Present)
Baylor College of Medicine
Department of Molecular and Human Genetics
Founder, CEO
(03/19 – Present)
Pneuma Nitric Oxide, LLC (N1O1)
Founder, CEO
(01/20 – Present)
Nitric Oxide Innovations, LLC
Founder, CEO
(03/21 – Present)
Bryan Nitriceuticals, LLC (NO2U)
Founder, CEO
(06/22 – Present)
Nitric Oxide Research Institute, LLC
Founder, Chairman CEO
(07/23 – Present)
Bryan Therapeutics, Inc.
Professional Organizations
Honors / Awards
LSU Health Sciences Center Graduate School Dean’s Award for Excellence in Graduate Studies – May 2005
Travel Award – Sept 2007 International Nitrite Meeting
Young Investigator Research Accomplishment Award – Presented by Dr. James T. Willerson – UTHSC Houston Sept 2007
UTHealth Star Award – Feb 2012
Innovations in Health Care 2024 – Health 2.0 Dubai UAE
Top 111 Forward Thinkers – 2025
The Top 100 Innovators and Entrepreneurs – 2024 & 2025
Editorial Positions
Journals
Journal of Geriatric Cardiology – Associate Editor
Alternative Therapies in Health and Medicine – Associate Editor
National Grant Review Panels / Study Sections
Service on UTHEALTH Committees
The University of Texas – Houston Animal Welfare Committee (2007 – 2010)
UT Houston Institute of Molecular Medicine Vivarium Subcommittee (2006 – 2014)
UT Houston Institute of Molecular Medicine Facilities Council (2007 – 2014)
UT Houston Medical School – Medical Student Interviewer (2010 – 2014)
UT Houston Medical School Admissions Committee (2011 – 2014)
Graduate School of Biomedical Sciences – Associate Faculty Member
Ph.D. Thesis Advisory Committee – Prasad Phatarpekar UT Graduate School of Biomedical Sciences
M.D. Ph.D. Thesis Advisory Committee – Henry Wu UT Graduate School of Biomedical Sciences
Ph.D. Advisory Committee – Richard Lions, DO Texas Childrens Hospital, Baylor College of Medicine
Service to the Community
Head Coach – Cy-Fair Sports Organization 9-10 year old JV football (2008)
Member Holy Family Catholic Church – Lexington Texas
Houston Community College Biotechnology Advisory Committee
Houston Community College Curriculum Advisory Committee
Lexington ISD Athletic Facility Fund Raising Committee – President
Lexington Independent School District – Facilities Committee (2016-Present)
Nitric Oxide Society – Treasurer
Sponsorship of Candidates for Postdoctoral Fellows
Yaoping Tang, M.D.
November 2007 – September 2010
Currently Vice Chairman of the Cardiovascular Center of Ruikang Hospital in Nanning China
Teaching Experience
Medical Physiology Course for Allied Health Professionals LSU Health Sciences Center: 2002
(8 lectures to 200 students)
Patient Oriented Problem Solving courses in Pharmacology to Medical Students
LSU Health Sciences Center: 2003
(20 lectures to 30 students)
Graduate Course in Cell Signaling: Department of Integrative Biology and Pharmacology
UTHSC Houston; Spring 2007-present
(5 lectures to 10 students)
Weekly lab meetings
(1.5 hours, 3 staff members)
Instructional teaching/mentoring in laboratory research – personal communications
(5 hours per weeks to 3 staff members and TCH physician)
Grant Support
Ruth L. Kirschstein National Research Service Award
Funding Period: 06/01/2004 – 05/31/2006
Grant Number: 5 T32 HL07224-27
Amount: $80,000
Institution: Whitaker Cardiovascular Institute, Boston University School of Medicine
Project Title: The Role of Nitrite as a Biologically Active Molecule in Physiology
Start-Up Funds
Funding Date: 06/01/2006
Institution: Institute of Molecular Medicine, The University of Texas Health Science Center at Houston
Amount: $150,000
Project Title: Nitrite Signaling and cGMP Formation
National Scientist Development Grant – American Heart Association
Role: Principal Investigator
Funding Period: 07/01/2007 – 06/30/2011
Grant Number: 0735042N
Amount: $260,000
Project Title: Supplemental Nitrite Restores NO Homeostasis and Enhances Cardiovascular Health
NIH Health Disparities Loan Repayment Program
Role: Principal Investigator
Funding Period: 10/01/2008 – 09/30/2011
Amount: $60,000
SAJE Pharmaceuticals
Role: Principal Investigator
Funding Period: 11/01/2008 – 06/30/2009
Amount: $3,500
Project Title: Preclinical Studies of GSNOR Inhibitors in Mice
Texas A&M University
Role: Principal Investigator
Funding Period: 11/08/2008 – 12/01/2009
Amount: $21,600
Project Title: A National Survey of the Nitrite/Nitrate Concentrations in Cured Meat Products and Non-Meat Foods Available at Retail
NIH Transformative R01 Grant
Role: Co-Principal Investigator
Funding Period: 09/01/2009 – 08/31/2014
Project Title: Arginosuccinate Lyase is an Essential Regulator of NO Production
Subcontract Amount: $500,000
NeoGenis Laboratories, Inc.
Role: Principal Investigator
Funding Period: 05/01/2010 – 09/30/2011
Amount: $75,000
Project Title: Development of Nitric Oxide-Based Nutraceuticals
Forest Research, Inc.
Role: Principal Investigator
Funding Period: 06/01/2011 – 12/31/2013
Amount: $150,000
Project Title: Inhibitory Activity of S-Nitrosoglutathione Reductase by Nebivolol: Novel Pathway for Modulating NO Signaling
NIH – National Center for Complementary and Integrative Health
Role: Principal Investigator
Funding Period: 10/01/2016 – 09/30/2017
Amount: $150,000
Project Title: The Effects of a Nitric Oxide Generating Lozenge on Peripheral Artery Disease
SCIENTIFIC PUBLICATIONS
[1] Joshi MS, Ferguson TB, Han TH, Hyduke DR, Liao JC, Rassaf T, Bryan NS, Feelisch M, Lancaster JR Jr.
Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions.
Proc Natl Acad Sci USA. 2002 Aug 6;99(16):10341-6.
[2] Feelisch M, Rassaf T, Mnaimneh S, Singh N, Bryan NS, Jourd’Heuil D, Kelm M.
Concomitant S-,N-, and heme nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo.
FASEB J. 2002 Nov;16(13):1775-85.
[3] Rassaf T, Bryan NS, Kelm M, Feelisch M.
Concomitant presence of N-nitroso and S-nitroso proteins in human plasma.
Free Radic Biol Med. 2002 Dec 1;33(11):1590-6.
[4] Rodriguez J, Maloney RE, Rassaf T, Bryan NS, Feelisch M.
Chemical nature of nitric oxide storage forms in rat vascular tissue.
Proc Natl Acad Sci USA. 2003 Jan 7;100(1):336-41.
[5] Rassaf T, Bryan NS, Maloney RE, Specian V, Kelm M, Kalyananraman B, Rodriguez J, Feelisch M.
NO adducts in mammalian red blood cells: too much or too little?
Nat Med. 2003 May;9(5):481-3.
[6] Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O, Scheeren T, Godecke A, Schrader J, Schulz R, Heusch G, Schaub GA, Bryan NS, Feelisch M, Kelm M.
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.
Free Radic Biol Med. 2003 Oct 1;35(7):790-6.
[7] Bryan NS, Rassaf T, Rodriguez C, Maloney R, Saijo F, Rodriguez J, Feelisch M.
Cellular targets and mechanisms of nitros(yl)ation: A first insight into their nature and kinetics in vivo.
Proc Natl Acad Sci USA. 2004 Mar 23;101(12):4308-4313.
[8] Bryan NS, Rassaf T, Rodriguez J, Feelisch M.
Bound NO in human red blood cells: fact or artifact?
Nitric Oxide. 2004 Jun;10(4):221-8.
[9] Tao L, Gao E, Bryan NS, Ou Y, Liu HR, Hu A, Christopher TA, Lopez BL, Yodio J, Koch WJ, Feelisch M, Ma XL.
Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: the role of S-nitrosation.
Proc Natl Acad Sci USA. 2004 Aug 3;101(31):11471-6.
[10] Janero DR, Bryan NS, Saijo F, Dhawan V, Schwalb DJ, Warren MC, Feelisch M.
Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo.
Proc Natl Acad Sci USA. 2004 Nov 30;101(48):16958-63.
[11] Zamora R, Bryan NS, Boyle P, Wong C, Milsom AB, Jaffe R, Feelisch M, Ford HR.
Nitrosative stress in an animal model of necrotizing enterocolitis.
Free Radic Biol Med. 2005 Dec 1;39(11):1428-1437.
[12] Bryan NS, Fernandez BO, Garcia-Saura MF, Bauer SM, Milsom AB, Rassaf T, Maloney R, Bharti A, Rodriguez J, Feelisch M.
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues.
Nature Chemical Biology. 2005 Oct;1(5):290-297.
[13] Peyrot F, Fernandez BO, Bryan NS, Feelisch M, Ducrocq C.
N-Nitroso Products from the Reaction of Indoles with Angeli’s Salt.
Chem Res Toxicol. 2006 Jan;19(1):58-67.
[14] Elrod JW, Greer JJ, Bryan NS, Langston W, Szot JF, Gebregzlabher H, Janssens S, Feelisch M, Lefer DJ.
Cardiomyocyte-Specific Overexpression of NO Synthase-3 Protects Against Myocardial Ischemia-Reperfusion Injury.
Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1517-23.
[15] Wang X, Bryan NS, MacArthur PH, Rodriguez J, Gladwin MT, Feelisch M.
Measurement of nitric oxide levels in the red cell: Validation of triiodide-based chemiluminescence with acid-sulfanilamide pretreatment.
J Biol Chem. 2006 Sep 15;281(37):26994-7002.
[16] Duranski MR, Elrod JW, Calvert JW, Bryan NS, Feelisch M, Lefer DJ.
Genetic Overexpression of eNOS Attenuates Hepatic Ischemia-Reperfusion Injury.
Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2980-6.
[17] Bryan NS.
Nitrite in NO Biology: Cause or Consequence? A Systems-Based Review.
Free Radic Biol Med. 2006 Sep;41(5):691-701.
[18] Bryan NS, Grisham MB.
Methods to Detect Nitric Oxide and its Metabolites in Biological Samples.
Free Radic Biol Med. 2007 Sep 1;43(5):645-57.
[19] Erzurum SC, Ghosh S, Janocha A, Xu W, Bauer S, Bryan NS, Tejero JB, Hemann C, Hille R, Stuehr D, Feelisch M, Beall C.
Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans.
Proc Natl Acad Sci USA. 2007 Nov 6;104(45):17593-8.
[20] Bryan NS, Calvert JW, Elrod JW, Duranski MR, Gundewar S, Ji SY, Lefer DJ.
Dietary Nitrite Supplementation Protects Against Myocardial Ischemia-Reperfusion Injury.
Proc Natl Acad Sci USA. 2007 Nov 27;104(48):19144-9.
[21] Elrod JW, Calvert JW, Gundewar S, Bryan NS, Lefer DJ.
Nitric Oxide Promotes Distant Organ Protection: Evidence for an Endocrine Role of Nitric Oxide.
Proc Natl Acad Sci USA. 2008 Aug 12;105(32):11430-35.
[22] Bryan NS, Calvert JW, Gundewar S, Lefer DJ.
Dietary Nitrite Restores NO Homeostasis and is Cardioprotective in eNOS Deficient Mice.
Free Radic Biol Med. 2008 Aug 15;45(4):468-74.
[23] Feelisch M, Fernandez BO, Bryan NS, Garcia-Saura MF, Bauer S, Whitlock DR, Ford PC, Janero DR, Rodriguez J, Ashrafian H.
Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems.
J Biol Chem. 2008 Dec 5;283(49):33927-34.
[24] Mujoo K, Sharin VG, Bryan NS, Krumenacker JS, Sloan C, Parveen S, Nikonoff LE, Kots AY, Murad F.
Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells.
Proc Natl Acad Sci USA. 2008 Dec 2;105(48):18924-9.
[25] Harg H, Bryan NS.
Dietary Sources of Nitrite as a Modulator of Ischemia-Reperfusion Injury.
Kidney Int. 2009 Jun;75(11):1140-4.
[26] Perlman DH, Bauer SM, Ashrafian H, Bryan NS, Garcia-Saura MF, Lim CC, Fernandez BO, Infusini G, McComb ME, Costello CE, Feelisch M.
Mechanistic Insights Into Nitrite-Induced Cardioprotection Using an Integrated Metabonomic/Proteomic Approach.
Circ Res. 2009 Mar 27;104(6):796-804.
[27] Stokes KY, Dugas TR, Tang Y, Garg H, Guidry E, Bryan NS.
Dietary Nitrite Prevents Hypercholesterolemic Microvascular Inflammation and Reverses Endothelial Dysfunction.
Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1281-8.
[28] Bryan NS, Bian K, Murad F.
Discovery of the Nitric Oxide Signaling Pathway and Targets for Drug Development.
Front Biosci. 2009 Jan 1;14:1-18.
[29] Bryan NS.
Cardioprotective Actions of Nitrite Therapy and Dietary Considerations.
Front Biosci. 2009 Jan 1;14:4793-808.
[30] Hord NG, Tang Y, Bryan NS.
Food Sources of Nitrates and Nitrites: The Physiological Context for Potential Health Benefits.
Am J Clin Nutr. 2009 Jul;90(1):1-10.
[31] Tang Y, Garg H, Geng YJ, Bryan NS.
Nitric Oxide Bioactivity of Traditional Chinese Medicines Used for Cardiovascular Indications.
Free Radic Biol Med. 2009 Sep 15;47(6):835-40.
[32] Sanghani PC, Davis WI, Fears SL, Green SL, Zhai L, Tang Y, Martin E, Bryan NS, Sanghani SP.
Kinetic and Cellular Characterization of Novel Inhibitors of S-Nitrosoglutathione Reductase.
J Biol Chem. 2009 Sep 4;284(36):24354-62.
[33] Milkowski A, Garg HK, Coughlin JR, Bryan NS.
Nutritional Epidemiology in the Context of Nitric Oxide Biology: A Risk-Benefit Evaluation for Dietary Nitrite and Nitrate.
Nitric Oxide. 2010 Feb 15;22(2):110-9.
[34] Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R.
Glutathione Peroxidase Deficiency Exacerbates Ischemia-Reperfusion Injury in Male but Not Female Myocardium: Insights Into Antioxidant Compensatory Mechanisms.
Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2144-53.
[35] Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E.
Nitrate and Nitrite in Biology, Nutrition and Therapeutics.
Nat Chem Biol. 2009 Dec;5(12):865-9.
[36] Saijo F, Milsom AB, Bryan NS, Bauer SM, Vowinkel T, Ivanovic M, Andry C, Granger DN, Rodriguez J, Feelisch M.
On the Dynamics of Nitrite, Nitrate, and Other Biomarkers of Nitric Oxide Production in Inflammatory Bowel Disease.
Nitric Oxide. 2010 Feb 15;22(2):155-67.
[37] Hord NG, Ghannam J, Garg HK, Berens PD, Bryan NS.
Nitrate and Nitrite Content of Human, Formula, Bovine, and Soy Milks: Implications for Dietary Nitrite and Nitrate Recommendations.
Breastfeed Med. 2011 Dec;6(6):393-9.
[38] Tang Y, Jiang H, Bryan NS.
Nitrite and Nitrate: Cardiovascular Risk-Benefit and Metabolic Effects.
Curr Opin Lipidol. 2011 Feb;22(1):11-5.
[39] Jourd’heuil FL, Lowery AM, Melton EM, Mnaimneh S, Bryan NS, Fernandez BO, Park JH, Ha CE, Bhagavan NV, Feelisch M, Jourd’heuil D.
Redox-Sensitivity and Site-Specificity of S- and N-Denitrosation in Proteins.
PLoS One. 2010 Dec 21;5(12):e14400.
[40] Bryan NS.
Processed Meats and Coronary Heart Disease: Perspective and Context.
Circulation. 2011 Jan 25;123(3):e16; author reply e17.
[41] Zand J, Lanza F, Garg HK, Bryan NS.
All-Natural Nitrite and Nitrate Containing Dietary Supplement Promotes Nitric Oxide Production and Reduces Triglycerides in Humans.
Nutr Res. 2011 Apr;31(4):262-9.
[42] Mian AI, Du Y, Garg HK, Caviness AC, Goldstein SL, Bryan NS.
Urinary Nitrate Might Be an Early Biomarker for Pediatric Acute Kidney Injury in the Emergency Department.
Pediatr Res. 2011 Aug;70(2):203-7.
[43] Dyson A, Bryan NS, Fernandez BO, Garcia-Saura MF, Saijo F, Mongardon N, Rodriguez J, Singer M, Feelisch M.
An Integrated Approach to Assessing Nitroso-Redox Balance in Systemic Inflammation.
Free Radic Biol Med. 2011 Jun 14;51(1):113-24.
[44] Aranke M, Bryan NS, Mian AI.
Towards Nitric Oxide Based Diagnostics: Call to Action.
Trends Mol Med. 2011 Nov;17(11):614-6.
[45] Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O’Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B.
Requirement of Argininosuccinate Lyase for Systemic Nitric Oxide Production.
Nat Med. 2011 Dec;17(12):1619-26.
[46] Garcia-Saura MF, Saijo F, Bryan NS, Bauer S, Rodriguez J, Feelisch M.
Nitroso-Redox Status and Vascular Function in Marginal and Severe Ascorbate Deficiency.
Antioxid Redox Signal. 2012 Feb 5;16(5):523-8.
[47] Mian AI, Bryan NS, Zaidi AK.
Translational Research in the Developing World: Molecular Medicine Goes Global.
Trends Mol Med. 2012 Mar;18(3):135-7.
[48] Nuñez De González MT, Osburn WN, Hardin MD, Longnecker M, Garg HK, Bryan NS, Keeton JT.
Survey of Residual Nitrite and Nitrate in Conventional and Organic/Natural/Uncured/Indirectly Cured Meats Available at Retail in the United States.
J Agric Food Chem. 2012 Apr 18;60(15):3981-90.
[49] Parthasarathy DK, Bryan NS.
Sodium Nitrite: The “Cure” for Nitric Oxide Insufficiency.
Meat Sci. 2012 Mar;92(3):274-9.
[50] Jiang H, Tang Y, Garg HK, Parthasarathy DK, Torregrossa AC, Hord NG, Bryan NS.
Concentration- and Stage-Specific Effects of Nitrite on Colon Cancer Cell Lines.
Nitric Oxide. 2012 Apr 5;26(3):193-8.
[51] Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B.
Nitric-Oxide Supplementation for Treatment of Long-Term Complications in Argininosuccinic Aciduria.
Am J Hum Genet. 2012 May 4;90(5):836-46.
[52] Jiang H, Torregrossa AC, Parthasarathy DK, Bryan NS.
Natural Product Nitric Oxide Chemistry: New Activity of Old Medicines.
Evid Based Complement Alternat Med. 2012;2012:873210.
[53] Bryan NS.
Application of Nitric Oxide in Drug Discovery and Development.
Expert Opin Drug Discov. 2011 Nov;6(11):1139-54.
[54] Jiang H, Parthasarathy D, Torregrossa AC, Mian A, Bryan NS.
Analytical Techniques for Assaying Nitric Oxide Bioactivity.
J Vis Exp. 2012 Jun 18;(64):e3722.
[55] Mujoo K, Nikonoff LE, Sharin VG, Bryan NS, Kots AY, Murad F.
Curcumin Induces Differentiation of Embryonic Stem Cells Through Possible Modulation of Nitric Oxide-Cyclic GMP Pathway.
Protein Cell. 2012 Jul;3(7):535-44.
[56] Torregrossa AC, Aranke M, Bryan NS.
Nitric Oxide and Geriatrics: Implications in Diagnostics and Treatment of the Elderly.
J Geriatr Cardiol. 2011 Dec;8(4):230-42.
[57] Bryan NS, Alexander DD, Coughlin JR, Milkowski AL, Boffetta P.
Ingested Nitrate and Nitrite and Stomach Cancer Risk: An Updated Review.
Food Chem Toxicol. 2012 Aug 4;50(10):3646-3665.
[58] Bryan NS.
Pharmacological Therapies, Lifestyle Choices, and Nitric Oxide Deficiency: A Perfect Storm.
Pharmacol Res. 2012 Dec;66(6):448-56.
[59] Bryan NS, Torregrossa AC, Mian AI, Lindsey Berkson D, Westby CM, Moncrief JW.
Acute Effects of Hemodialysis on Nitrite and Nitrate: Potential Cardiovascular Implications in Dialysis Patients.
Free Radic Biol Med. 2013 Jan 29;58C:46-51.
[60] Mian AI, Aranke M, Bryan NS.
Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making.
Open Biochem J. 2013;7:24-32.
[61] Chintalgattu V, Rees ML, Culver JC, Goel A, Jiffar T, Zhang J, Dunner K Jr, Pati S, Bankson JA, Pasqualini R, Arap W, Bryan NS, Taegtmeyer H, Langley RR, Yao H, Kupferman ME, Entman ML, Dickinson ME, Khakoo AY.
Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate-Induced Cardiotoxicity.
Sci Transl Med. 2013 May 29;5(187):187ra69.
[62] Jiang H, Torregrossa AC, Potts A, Pierini D, Aranke M, Garg HK, Bryan NS.
Dietary Nitrite Improves Insulin Signaling Through GLUT4 Translocation.
Free Radic Biol Med. 2013 Oct 21;67C:51-57.
[63] Hyde ER, Andrade F, Vaksman Z, Parthasarathy K, Jiang H, Parthasarathy DK, Torregrossa AC, Tribble G, Kaplan HB, Petrosino JF, Bryan NS.
Metagenomic Analysis of Nitrate-Reducing Bacteria in the Oral Cavity: Implications for Nitric Oxide Homeostasis.
PLoS One. 2014 Mar 26;9(3):e88645.
[64] Oostindjer M, Alexander J, Amdam GV, Andersen G, Bryan NS, Chen D, Corpet DE, De Smet S, Dragsted LO, Haug A, Karlsson AH, Kleter G, de Kok TM, Kulseng B, Milkowski AL, Martin RJ, Pajari AM, Paulsen JE, Pickova J, Rudi K, Sødring M, Weed DL, Egelandsdal B.
The Role of Red and Processed Meat in Colorectal Cancer Development: A Perspective.
Meat Sci. 2014 Aug;97(4):583-96.
[65] Premkumar MH, Sule G, Nagamani SC, Chakkalakal S, Nordin A, Jain M, Ruan MZ, Bertin T, Dawson BC, Zhang J, Schady D, Bryan NS, Campeau PM, Erez A, Lee B.
Argininosuccinate Lyase in Enterocytes Protects from Development of Necrotizing Enterocolitis.
Am J Physiol Gastrointest Liver Physiol. 2014 Jun 5.
[66] Hyde ER, Luk B, Cron S, Kusic L, McCue T, Bauch T, Kaplan H, Tribble G, Petrosino JF, Bryan NS.
Characterization of the Rat Oral Microbiome and the Effects of Dietary Nitrate.
Free Radic Biol Med. 2014 Dec;77:249-57.
[67] Pierini D, Bryan NS.
Nitric Oxide Availability as a Marker of Oxidative Stress.
Methods Mol Biol. 2015;1208:63-71.
[68] Justice JN, Gioscia-Ryan RA, Johnson LC, Battson ML, de Picciotto NE, Beck HJ, Jiang H, Sindler AL, Bryan NS, Enoka RM, Seals DR.
Sodium Nitrite Supplementation Improves Motor Function and Skeletal Muscle Inflammatory Profile in Old Male Mice.
J Appl Physiol (1985). 2015 Jan 15;118(2):163-9.
[69] Bryan NS.
The Potential Use of Salivary Nitrite as a Marker of NO Status in Humans.
Nitric Oxide. 2015 Feb 15;45:4-6.
[70] Sindler AL, Cox-York K, Reese L, Bryan NS, Seals DR, Gentile CL.
Oral Nitrite Therapy Improves Vascular Function in Diabetic Mice.
Diab Vasc Dis Res. 2015 Feb 12.
[71] Nuñez de González MT, Osburn WN, Hardin MD, Longnecker M, Garg HK, Bryan NS, Keeton JT.
A Survey of Nitrate and Nitrite Concentrations in Conventional and Organic-Labeled Raw Vegetables at Retail.
J Food Sci. 2015 May;80(5):C942-9.
[72] Bryan NS, Ivy JL.
Inorganic Nitrite and Nitrate: Evidence to Support Consideration as Dietary Nutrients.
Nutr Res. 2015 Aug;35(8):643-54.
[73] DeVan AE, Johnson LC, Brooks FA, Evans TD, Justice JN, Cruickshank-Quinn C, Reisdorph N, Bryan NS, McQueen MB, Santos-Parker JR, Chonchol MB, Bassett CJ, Sindler AL, Giordano T, Seals DR.
Effects of Sodium Nitrite Supplementation on Vascular Function and Related Small Metabolite Signatures in Middle-Aged and Older Adults.
J Appl Physiol (1985). 2015 Nov 25.
[74] Justice JN, Johnson LC, DeVan AE, Cruickshank-Quinn C, Reisdorph N, Bassett CJ, Evans TD, Brooks FA, Bryan NS, Chonchol MB, Giordano T, McQueen MB, Seals DR.
Improved Motor and Cognitive Performance with Sodium Nitrite Supplementation is Related to Small Metabolite Signatures: A Pilot Trial in Middle-Aged and Older Adults.
Aging (Albany NY). 2015 Nov;7(11):1004-21.
[75] Jiang H, Polhemus DJ, Islam KN, Torregrossa AC, Li Z, Potts A, Lefer DJ, Bryan NS.
Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New Mechanism of Action.
J Cardiovasc Pharmacol Ther. 2016 Jan 8.
[76] Bryan NS, Tribble G, Angelov N.
Oral Microbiome and Nitric Oxide: The Missing Link in the Management of Blood Pressure.
Curr Hypertens Rep. 2017 Apr;19(4):33.
[77] Raizada MK, Joe B, Bryan NS, Chang EB, Dewhirst FE, Borisy GG, Galis ZS, Henderson W, Jose PA, Ketchum CJ, Lampe JW, Pepine CJ, Pluznick JL, Raj D, Seals DR, Gioscia-Ryan RA, Tang WHW, Oh YS.
Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions.
Hypertension. 2017 Jul 31.
[78] Bock JM, Ueda K, Schneider AC 4th, Hughes WE, Limberg JK, Bryan NS, Casey DP.
Inorganic Nitrate Supplementation Attenuates Peripheral Chemoreflex Sensitivity but Does Not Improve Cardiovagal Baroreflex Sensitivity in Older Adults.
Am J Physiol Heart Circ Physiol. 2017 Sep 29.
[79] McMahon TJ, Bryan NS.
Biomarkers in Pulmonary Vascular Disease: Gauging Response to Therapy.
Am J Cardiol. 2017 Oct 15;120(8S):S89-S95.
[80] Bryan NS.
Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease.
Curr Atheroscler Rep. 2018 Mar 17;20(5):21.
[81] Functional Nitric Oxide Nutrition of Combat Cardiovascular Disease.
Bryan NS.
Curr Atheroscler Rep. 2018 Mar 17;20(5):21.
[82] Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension.
Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH.
Am J Hum Genet. 2018 Aug 2;103(2):276-287.
[83] Enhancement of gemcitabine cytotoxicity in pancreatic adenocarcinoma through controlled release of nitric oxide.
Araujo-Gutierrez R, Van Eps JL, Kirui D, Bryan NS, Kang Y, Fleming JB, Fernandez-Moure JS.
Biomed Microdevices. 2019 Feb 21;21(1):23.
[84] Frequency of Tongue Cleaning Impacts the Human Tongue Microbiome Composition and Enterosalivary Circulation of Nitrate.
Tribble GD, Angelov N, Weltman R, Wang BY, Eswaran SV, Gay IC, Parthasarathy K, Dao DV, Richardson KN, Ismail NM, Sharina IG, Hyde ER, Ajami NJ, Petrosino JF, Bryan NS.
Front Cell Infect Microbiol. 2019 Mar 1;9:39.
[85] Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics.
Bryan NS, Lefer DJ.
Mol Pharmacol. 2019 Jul;96(1):109-114.
[86] Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country.
Waheed S, Kalsekar AG, Kamal AK, Bryan NS, Mian AI.
Emerg Med Int. 2019 Jun 2;2019:9206948.
[87] A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health.
Banez MJ, Geluz MI, Chandra A, Hamdan T, Biswas OS, Bryan NS, Von Schwarz ER.
Nutr Res. 2020 Jun;78:11-26.
[88] Inorganic Nitrite Supplementation Improves Endothelial Function With Aging: Translational Evidence for Suppression of Mitochondria-Derived Oxidative Stress.
Rossman MJ, Gioscia-Ryan RA, Santos-Parker JR, Ziemba BP, Lubieniecki KL, Johnson LC, Poliektov NE, Bispham NZ, Woodward KA, Nagy EE, Bryan NS, Reisz JA, D’Alessandro A, Chonchol M, Sindler AL, Seals DR.
Hypertension. 2021 Apr;77(4):1212-1222.
[89] Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination.
Fernandez-Moure JS, Van Eps JL, Scherba JC, Haddix S, Livingston M, Bryan NS, Cantu C, Valson C, Taraballi F, Kaplan LJ, Olsen R, Tasciotti E.
Surg Infect (Larchmt). 2021 Apr 30.
[90] The effect of continuous venovenous hemodiafiltration on amino acid delivery, clearance, and removal in children.
Lion RP, Vega MR, Smith EO, Devaraj S, Braun MC, Bryan NS, Desai MS, Coss-Bu JA, Ikizler TA, Akcan Arikan A.
Pediatr Nephrol. 2022 Feb;37(2):433-441.
[91] The oral microbiome, nitric oxide and exercise performance.
Bryan NS, Burleigh MC, Easton C.
Nitric Oxide. 2022 Aug 1;125-126:23-30.
[92] Nitric oxide deficiency is a primary driver of hypertension.
Bryan NS.
Biochem Pharmacol. 2022 Dec;206:115325.
[93] Dietary nitrate biochemistry and physiology. An update on clinical benefits and mechanisms of action.
Bryan NS, Ahmed S, Lefer DJ, Hord N, von Schwarz ER.
Nitric Oxide. 2023 Mar 1;132:1-7.
[94] The Efficacy of Nitric Oxide-Generating Lozenges on Outcome in Newly Diagnosed COVID-19 Patients of African American and Hispanic Origin.
Bryan NS, Molnar J, Somberg J.
Am J Med. 2023 Oct;136(10):1035-1040.e11.
Edited Books
[1] Bryan NS (Editor).
Food, Nutrition and the Nitric Oxide Pathway.
DesTech Publishing – Pennsylvania. ISBN: 978-1-932078-84-8, September 2009.
[2] Bryan NS and Loscalzo J (Editors).
Nitrite and Nitrate in Human Health and Disease.
Springer Humana Press – New York. ISBN: 978-1-60761-615-3, May 2011.
[3] Bryan NS and Loscalzo J (Editors).
Nitrite and Nitrate in Human Health and Disease (Second Edition).
Springer Humana Press – New York. ISBN: 978-3-319-46189-2, January 2017.
Books Chapters
[1] Bryan NS, Murad F.
What is Nitric Oxide?
In Food, Nutrition and the Nitric Oxide Pathway (Ed.) Bryan NS.
DesTech Publishing – Pennsylvania. ISBN: 978-1-932078-84-8, September 2009.
[2] Grisham MB, Bryan NS.
Dysregulated NO and Disease.
In Food, Nutrition and the Nitric Oxide Pathway (Ed.) Bryan NS.
DesTech Publishing – Pennsylvania. ISBN: 978-1-932078-84-8, September 2009.
[3] Bryan NS, Hord NG.
Food Sources of Nitrite and Nitrate: The Physiological Context for Potential Health Benefits.
In Food, Nutrition and the Nitric Oxide Pathway (Ed.) Bryan NS.
DesTech Publishing – Pennsylvania. ISBN: 978-1-932078-84-8, September 2009.
[4] Huffman R, Bryan NS.
Nitrite and Nitrate in the Meat and Food Industry.
In Food, Nutrition and the Nitric Oxide Pathway (Ed.) Bryan NS.
DesTech Publishing – Pennsylvania. ISBN: 978-1-932078-84-8, September 2009.
[5] Bryan NS, Hord NG.
Regulations Gone Awry: Addressing Public Concerns.
In Food, Nutrition and the Nitric Oxide Pathway (Ed.) Bryan NS.
DesTech Publishing – Pennsylvania. ISBN: 978-1-932078-84-8, September 2009.
[6] Bryan NS, Hord NG.
Diet and Endothelium – A Concert in NO Homeostasis.
In Food, Nutrition and the Nitric Oxide Pathway (Ed.) Bryan NS.
DesTech Publishing – Pennsylvania. ISBN: 978-1-932078-84-8, September 2009.
[7] Bryan NS.
Paradigm Shift: From Toxic Food Additive to Indispensable Nutrient.
In Food, Nutrition and the Nitric Oxide Pathway (Ed.) Bryan NS.
DesTech Publishing – Pennsylvania. ISBN: 978-1-932078-84-8, September 2009.
[8] Bryan NS, Van Grinsven H.
The Role of Nitrate in Human Health.
In Advances in Agronomy (Ed.) Donald S.
Academic Press. ISBN: 978-0-12-407247-3, 2013.
[9] Harsha K. Garg, Bryan NS.
Inorganic Nitrite and Nitrate Are Bioactive Food Components Conferring Nitric Oxide Activity In Vivo.
In Functional Foods for Chronic Diseases Volume 5: Diabetes and Related Diseases (Eds.) N. Abate & D.K. Martirosyan.
Food Science Publisher. ISBN-10: 0976753561, July 2010.
[10] Bryan NS, Loscalzo J.
Introduction.
In Nitrite and Nitrate in Human Health and Disease (Eds.) Bryan NS, Loscalzo J.
Springer-Humana Press. ISBN: 978-1-60761-615-3, May 2011.
[11] Berens P, Bryan NS.
Nitrite and Nitrate in Human Breast Milk: Implications for Development.
In Nitrite and Nitrate in Human Health and Disease (Eds.) Bryan NS, Loscalzo J.
Springer-Humana Press. ISBN: 978-1-60761-615-3, May 2011.
[12] Bryan NS, Lancaster JL.
Nitric Oxide Signaling in Health and Disease.
In Nitrite and Nitrate in Human Health and Disease (Eds.) Bryan NS, Loscalzo J.
Springer-Humana Press. ISBN: 978-1-60761-615-3, May 2011.
[13] Bryan NS, Loscalzo J.
Looking Forward.
In Nitrite and Nitrate in Human Health and Disease (Eds.) Bryan NS, Loscalzo J.
Springer-Humana Press. ISBN: 978-1-60761-615-3, May 2011.
[14] Bryan NS, Van Grinsven H.
The Role of Nitrate in Human Health.
In Advances in Agronomy (Ed.) Donald S.
Academic Press. ISBN: 978-0-12-407247-3, 2013.
[15] Parthasarathy D, Bryan NS.
Curing: Physiology of Nitric Oxide.
In Encyclopedia of Meat Sciences (2nd Edition) (Ed.) Dikeman M.
Elsevier Publishing, 2012.
[16] Pierini D, Bryan NS.
Nitric Oxide Availability as a Marker of Oxidative Stress.
In Advanced Protocols in Oxidative Stress III (Ed.) Armstrong D.
Humana Press, 2014.
[17] Bryan NS.
Nitric Oxide Enhancement Strategies.
In Development and Therapeutic Applications of Nitric Oxide Releasing Materials (Eds.) Friedman A, Friedman J.
Future Science Ltd, 2014.
[18] Bryan NS.
An Overview of Nitrite and Nitrate: New Paradigm of Nitric Oxide.
In Sustained Energy for Enhanced Human Functions and Physical Activity (Ed.) Debasis Bagchi.
[19] Vascular Biology and Vascular Aging for the Clinician
Bryan NS, Schwarz E.
In: Cardiovascular Medicine Textbook: An Integrative, Metabolic and Functional Medicine Approach. Mark Houston, M.D. (Ed).
Wolters Kluwer Health, Inc.
[20] Mesothelial Stem Cells and Stromal Vascular Fraction: Use in Functional Disorders, Wound Healing, Fat Transfer and Other Conditions
Chernoff G, Bryan NS.
In: Facial Plastic Surgery Clinics in North America. New Trends and Technologies in Facial Plastic Surgery. J Reagan Thomas, M.D. (Ed).
Elsevier ISSN: 1064-7406
[21] Safe and Effective Use of Nitric Oxide-Based Supplements and Nutrition for Sports Performance
Bryan NS.
In: Nutrition and Enhanced Sports Performance: Muscle Building, Endurance and Strength, 2nd Edition. Debasis Bagchi (Ed).
Elsevier
[22] Inorganic Nitrite and Nitrate: Dietary Nutrients or Poisons
Bryan NS.
In: Nitrate Handbook: Environmental, Agricultural, and Health Effects. Edited by Christos Tsadilas.
First Edition, 2022. Boca Raton, FL: CRC Press.
[23] Vascular Biology and Vascular Aging for the Clinician
Bryan NS, Ernst Von Schwarz.
In: Personalized and Precision Integrative Cardiovascular Medicine. Mark Houston, M.D. (Ed).
LWW, 2019.
[24] The Role of Nitric Oxide Supplements and Foods in Cardiovascular Disease
Bryan NS, Ernst Von Schwarz.
In: Nutrition and Integrative Strategies in Cardiovascular Medicine. Houston and Sinatra, Editors.
CRC Press, 2021.
Authored Books
[1] Blood and Tissue Nitric Oxide Products: Formation and Physiological Significance
Nathan S. Bryan
ISBN: 3639178092; August 2009
[2] The Nitric Oxide (NO) Solution
Nathan S. Bryan & Janet Zand with Bill Gottlieb
Good for You Books Publishing
ISBN: 978-0-615-41713-4; November 2010
[3] Beet the Odds
Nathan S. Bryan & Caroline Pierini
ISBN: 978-1-9888135-0-2; 2013
[4] Functional Nitric Oxide Nutrition: Dietary Strategies to Prevent and Treat Chronic Disease
Nathan S. Bryan
ISBN (Print): 978-1-948719-00-1
ISBN (Ebook): 978-1-948719-01-8
2018
[5] The Secret of Nitric Oxide: Bringing Nitric Oxide to Life
Nathan S. Bryan
J. Boylston Publishers
February 2025
Invited Lecturers
International Presentations & Lectures
[1] Physiological Basal Nitrosation Levels: The Art of the Method – Invited Lecture
Heinrich-Heine University, Division of Cardiology, Pulmonary Diseases, and Angiology, Düsseldorf, Germany, June 2002.
[2] Nitrite-Mediated Blood and Tissue Nitros(yl)ation
Society for Free Radical Biology and Medicine Meeting, St. Thomas, Virgin Islands, November 2004.
[3] Nitric Oxide Enhancement Restores Endothelial Function and Combats Adverse Effects of Homocysteine
Trivita Medical Advisory Board Meeting – Invited Speaker, Vancouver, BC, August 2007.
[4] Dietary Nitrite and Nitrate Contribute to Cardiovascular Health and Disease
Invited Plenary Speaker, Lisbon, Portugal, February 20-24, 2008.
[5] Dietary Nitrite and Nitrate as Indispensable Nutrients
International Meeting on the Role of Nitrite in Physiology, Pathophysiology, and Therapeutics – Invited Speaker, Nobel Forum, Stockholm, Sweden, June 18-19, 2009.
[6] Inorganic Nitrite and Nitrate as Novel Therapeutic Agents to Restore NO Homeostasis
The Ninth Conference of Chinese Integrated Medicine on Cardiovascular Diseases – Invited Speaker, Tianjin, China, September 5, 2009.
[7] Inorganic Nitrite and Nitrate as Novel Therapeutic Agents to Restore NO Homeostasis
Guangxi Traditional Chinese Medical University – Ruikang Hospital, Nanning, China, September 7, 2009.
[8] The Nitrate-Nitrite-Nitric Oxide Pathway – Invited Speaker
World Health Organization and France National Academy of Medicine, Hôpital Pitié-Salpêtrière, Paris, France, March 31, 2011.
[9] Nitric Oxide Index of Foods: Defining the Context for Health Benefits of Dietary Nitrite and Nitrate While Mitigating Risk – Invited Speaker
World Health Organization and France National Academy of Medicine, Hôpital Pitié-Salpêtrière, Paris, France, March 31, 2011.
[10] Emerging Health Benefits of Nitrite and Nitrate: A Change in Paradigm – Keynote Speaker
International Congress of Meat Science and Technology, Montreal, Canada, August 12-17, 2012.
[11] Emerging Health Benefits of Nitrite and Nitrate: A Change in Paradigm
Maple Leaf Foods, Toronto, Canada, September 24, 2012.
[12] Nitric Oxide Deficiency and Restoration: New Discoveries in Cardiovascular and Sexual Health
Orthomolecular Medicine Conference, São Paulo, Brazil, May 9-11, 2013.
[13] Dietary Nitrite and Nitrate: From Menace to Marvel
Canadian Nutrition Society Annual Meeting, Quebec City, May 30 – June 2, 2013.
[14] An Update on Nitric Oxide Research: New Innovations and Product Solutions
Canadian Health Food Association, September 4, 2013.
[15] Why Dietary Nitrite and Nitrate May Be Good for You
Centre for Advanced Studies at The Norwegian Academy of Science and Letters, Oslo, Norway, November 6-7, 2013.
[16] New Paradigm for Regulation of Endogenous Nitric Oxide Production in Humans: The Oral Systemic Link
Karolinska Institute, Stockholm, Sweden, November 8, 2013.
[17] What is Nitric Oxide and Why Should You Care?
Canadian Health Food Association, Toronto, ON, September 12, 2014.
[18] Nitric Oxide Deficiency & Restoration: New Discoveries in Cardiovascular & Sexual Health
Canadian Health Food Association, Vancouver, BC, April 10, 2015.
[19] GSNO Reductase as a Therapeutic Target
International Nitric Oxide Conference, Sendai, Japan, May 20-22, 2016.
[20] The Role of Nitric Oxide in the Management of Hypertension, Inflammation, and Cardiovascular Disease
Functional and Regenerative Medicine Conference, Auckland, New Zealand, June 7, 2017.
[21] The Role of Nitric Oxide in Primary Care
General Practice Conference and Medical Education, Rotorua, New Zealand, June 8-11, 2017.
[22] Erectile Dysfunction is Endothelial Dysfunction: Understanding the Symptoms That Lead to Heart Disease
General Practice Conference and Medical Education, Rotorua, New Zealand, June 8-11, 2017.
[23] Nitric Oxide, So What?
General Practice Conference and Medical Education, Rotorua, New Zealand, June 8-11, 2017.
[24] Nitric Oxide in Heart Disease
General Practice Conference and Medical Education, Rotorua, New Zealand, June 8-11, 2017.
[25] What is NO and Why Should You Care?
General Practice Conference and Medical Education, Rotorua, New Zealand, June 8-11, 2017.
[26] Evidenced-Based Therapeutic Strategies for Anti-Aging Medicine
A4M Dubai, January 19-21, 2018.
[27] Oral Microbiome, Nitric Oxide, and Systemic Health
World Dental Forum, Dubai, April 2-4, 2018.
[28] The Physiological and Therapeutic Role of Nitric Oxide
Dubai External Counterpulsation Symposium and Workshop, Dubai, UAE, Sept 8-9, 2018
[29] The Effect of Light Therapy on Nitric Oxide
Global Wellness Summit, Cessena, Italy, Oct 6-8, 2018
[30] Nitric Oxide in Acute Care
21st National Health Sciences Research Symposium Emergency Care: Time & Life Matter – Aga Khan University, Karachi, Pakistan, Nov 9-11, 2018
[31] The Role of Nitric Oxide in Anti-Aging and Regenerative Medicine
Anti-Aging Medicine Conference, Mexico City, Mexico, Feb 15-17, 2019
[32] New Paradigm in the Regulation and Production of Nitric Oxide in Humans: Translating Basic Science
Behai, China, Aug 17, 2019
[33] New Paradigm in the Regulation and Production of Nitric Oxide in Humans: Translating Basic Science
Guangxi University of Chinese Medicine, Nanning, China, Aug 17, 2019
[34] Functional Nitric Oxide Nutrition to Restore Vascular Function: Optimization of Brain Perfusion and Detoxification
Third International Forum on Nutritional Medicine, Beijing, China, October 2019
[35] The Role of Nitric Oxide for Optimal Health
Regenerative Medicine Congress, Mexico City, Sept 13, 2020
[36] The Use of Nitric Oxide Generating Lozenge to Prevent Rapid Progression of COVID-19 and Other Health Benefits
Norvick International Hospital, Kathmandu, Nepal, Aug 2021
[37] Importance of Nitric Oxide in Health, Hormones and Circulation
Biohacking and Longevity Convention, Arsinal, Andorra, July 5-7, 2024
[38] The Role of Nitric Oxide in Regenerative Medicine
10th International Congress on Longevity and Integrative Therapies, Sao Paulo, Brazil, Nov 16, 2024
[39] Are You Building Bridges or Walls to Traditional Medicine?
Health 2.0, Dubai, UAE, Dec 5, 2024
National Presentations & Lectures
[1] Formation and Physiological Significance of Blood and Tissue Nitrosation/Nitrosylation Products – Invited Seminar Speaker
LSU Health Sciences Center, June 2004.
[2] Dietary Nitrite Contributes to Cardiovascular Health and Disease – Invited Speaker
Institute of Food Technologists, Chicago, IL, July 2007.
[3] Dietary Nitrite and Nitrate Contribute to Cardiovascular Health and Disease – Plenary Speaker
Worldwide Food Expo, Chicago, IL, October 2007.
[4] Dietary Nitrite and Nitrate Contribute to Cardiovascular Health and Disease – Invited Speaker
LSU Health Science Center, Department of Molecular and Cellular Physiology, January 23, 2008.
[5] Dietary Nitrite and Nitrate Contribute to Cardiovascular Health and Disease – Invited Speaker
Michigan State University, Department of Food Science and Human Nutrition, February 30, 2008.
[6] Nitrites: Essential to Health? A New Story About an Old Antimicrobial – Invited Speaker
International Association for Food Protection Annual Conference, Columbus, OH, August 6, 2008.
[7] Dietary Nitrite and Nitrate as Indispensable Nutrients – Invited Speaker
Kraft Meat Summit, Madison, WI, June 25, 2009.
[8] Dietary Nitrite and Nitrate as Indispensable Nutrients – Invited Speaker
University of Wisconsin, Department of Animal Science, Madison, WI, June 26, 2009.
[9] Inorganic Nitrite and Nitrate are Bioactive Food Components Conferring Nitric Oxide Activity In Vivo – Invited Speaker
Functional Foods Conference, Denton, TX, December 4-5, 2009.
[10] Nature’s NO: Novel Strategies to Restore Nitric Oxide Homeostasis – Invited Speaker
Wake Forest Nitrogen Oxide Meeting, Nemacolin Resort, Farmington, PA, May 28-30, 2010.
[11] Dietary Nitrite and Nitrate: From Menace to Marvel – Invited Speaker
Reciprocal Meat Conference, Lubbock, TX, June 20-23, 2010.
[12] Nitric Oxide in Health and Disease – Invited Speaker
Austin Functional Medicine Group, Austin, TX, October 28, 2010.
[13] Nitric Oxide in Health and Disease – Invited Speaker
San Antonio Functional Medicine Group, San Antonio, TX, November 3, 2010.
[14] Approaches for Diagnosing and Restoring Nitric Oxide Production in Humans – Invited Speaker
Wake Forest University Translational Science Center, Winston-Salem, NC, April 4, 2011.
[15] Nitric Oxide: The Overlooked Molecule in Patient Care – Invited Speaker
CME Lecture, American Academy of Anti-Aging Medicine Conference, Orlando, FL, April 7, 2011.
[16] Nature’s NO: Harnessing the Therapeutic Potential of The Nitrate-Nitrite-Nitric Oxide Pathway from Natural Products – Invited Speaker
Approaching the Clinic: Nitrite and Nitrate Conference, Atlanta, GA, May 11-13, 2011.
[17] Nitric Oxide in Health and Disease – Invited Speaker
Pastoral Medical Association, Austin, TX, May 21, 2011.
[18] Nitric Oxide Diagnostics and Therapeutics – Invited Speaker
International Conference and Exhibition on Clinical Research: Dermatology, Ophthalmology, and Cardiology, San Francisco, CA, July 5-6, 2011.
[19] Nitrite and Nitrate in Health and Disease: A Paradigm Shift – Invited Speaker
Joint Annual Meeting: ADSA and ASAS 2011, New Orleans, LA, July 12, 2011.
[20] Nitric Oxide: The Miracle Molecule – Invited Speaker
Synergy Medical Group, Salt Lake City, UT, July 22-23, 2011.
[21] Nitric Oxide in Health and Disease: A New Paradigm for Healthy Living – Invited Speaker
Exxon Annual Safety Meeting – Heart Health, Houston, TX, August 8, 2011.
[22] Nitric Oxide in Health and Disease: An Update on Current Research – Invited Speaker
Synergy Medical Group, Phoenix, AZ, October 28, 2011.
[23] Nitric Oxide in Health and Disease: An Overview of Current Research – Invited Speaker
14th International Congress of BioEnergetic Medicine, Orlando, FL, November 4, 2011.
[24] Nitric Oxide: The Overlooked Molecule in Patient Care – Keynote Lecture, CME
19th Annual World Congress on Anti-Aging and Aesthetic Medicine, Las Vegas, NV, December 8-10, 2011.
[25] Nitric Oxide in Health and Disease: An Overview of Current Research – Invited Speaker
Hawaii Spa Marketplace, Honolulu, HI, January 23, 2012.
[26] A Novel Method for Nitric Oxide Production – Invited Speaker
American Academy of Ozonotherapy, Dallas, TX, February 17-18, 2012.
[27] Nitric Oxide in Health and Disease: An Overview of Current Research – Invited Speaker
Crossroads Apothecary, Columbia, MD, March 16, 2012.
[28] Novel Strategies to Diagnose and Restore Nitric Oxide Production in Humans – Invited Speaker
Hawaii Institute of Molecular Education, Las Vegas, NV, June 5-6, 2012.
[29] Nitric Oxide Signaling: Its Physiological Importance to Nitrite, Nitrate, and Nitrosation Reactions – Invited Speaker
Institute of Food Technologists, Las Vegas, NV, June 28, 2012.
[30] Nitric Oxide in Health and Disease: An Overview of Current Research
Empowered Doctors, Miami, FL, August 8, 2012.
[31] Nitric Oxide in Health and Disease: An Overview of Current Research
Leadership and Longevity Conference, Green Bay, WI, October 25-26, 2012.
[32] Nitric Oxide in Health and Disease: An Overview of Current Research
Heart Institute of Southern California, Temecula, CA, January 31, 2013.
[33] Nitric Oxide in Health and Disease: An Overview of Current Research
Physician Training, Newport Beach, CA, February 2, 2013.
[34] Nitric Oxide in Health and Disease: An Overview of Current Research
Heart Attack and Stroke Prevention Alliance, Dallas, TX, February 16, 2013.
[35] Nitrite and Nitrate in Health and Disease – Invited Lecture
University of Colorado, Department of Integrative Physiology, Boulder, CO, February 25, 2013.
[36] Nitric Oxide Generating Bacteria Affect Cardiovascular Health of Host: Linking Oral Health to Cardiovascular Disease – Invited Speaker
Holistic Dental Association, Washington, DC, April 19, 2013.
[37] Nitric Oxide Deficiency & Restoration: New Discoveries in Cardiovascular & Sexual Health
Age Management Medicine Group, Hollywood, FL, May 2, 2013.
[38] An Update on Nitric Oxide Research
Baylor College of Medicine, Department of Obstetrics and Gynecology, August 19, 2013.
[39] The Role of Nitric Oxide in Pain, Inflammation, and Arthritis
Florida Chiropractors Association, Orlando, FL, August 24, 2013.
[40] Oral Microbial Nitric Oxide Production: Linking Oral Health & Cardiovascular Disease
International Academy of Biological Dentistry and Medicine, Houston, TX, October 11-13, 2013.
[41] New Paradigm on the Production and Regulation of Nitric Oxide: Advancements in Diagnostics and Therapeutics – Invited Lecture
Houston Methodist Research Institute, Department of Cardiovascular Sciences, January 24, 2014.
[42] Revolutionary Advancement in Nitric Oxide (NO): Renewal Beyond L-Arginine – The Premise for Health, Cellular Anti-Aging, Prevention & Disease Management
American Academy of Ozonotherapy, Dallas, TX, March 26, 2014.
[43] New Paradigm for Regulation of Endogenous Nitric Oxide in Humans: The Oral Systemic Link
Dallas, TX, April 12, 2014.
[44] Nitric Oxide, Menopause, and Female Sexual Arousal Disorder – Invited Lecture, CME
American Academy of Anti-Aging Medicine, Orlando, FL, May 17, 2014.
[45] The Truth About Dietary Nitrates and Mechanisms for Nitric Oxide Production in Humans
Collegiate and Professional Sports Dietitian Association (CPSDA), Scottsdale, AZ, May 20, 2014.
[46] The Role of Nitric Oxide in Gastrointestinal Health and Chronic Disease
12th Annual Restorative Medicine Conference, Santa Fe, NM, October 8-12, 2014.
[47] The Truth About Dietary Nitrates and Mechanisms for Nitric Oxide Production in Humans
The Food and Nutrition Conference and Expo, Atlanta, GA, October 20, 2014.
[48] The Role of Nitric Oxide in Cellular Aging: Telomeres, Mitochondria, and Stem Cells
Academy of Comprehensive Integrative Medicine, Santa Fe, NM, October 24, 2014.
[49] Advancements in Nitric Oxide Diagnostics and Therapeutics: Combatting Sexual Dysfunction for Men and Women
Age Management Medicine Group, Las Vegas, NV, November 7, 2014.
[50] The Role of Bacteria in Anti-Aging Medicine: Nitric Oxide and Beyond
American Academy of Anti-Aging Medicine, Las Vegas, NV, December 12, 2014.
[51] Clinical Use of Nitric Oxide Therapy
American Academy of Ozonotherapy, Dallas, TX, February 20, 2015.
[52] Sodium Nitrite: The Cure for Cardiovascular Disease
Iowa State University, Department of Animal Science Seminar Series, Ames, IA, March 27, 2015.
[53] Nitric Oxide Supplementation: The Good, the Bad, and the Ugly
Austin Functional Medicine, Austin, TX, March 12, 2015.
[54] Chiropractic Nitric Oxide Nutrition
Fetterman Chiropractic Organization, Milwaukee, WI, April 18, 2015.
[55] Nitric Oxide Supplementation: Biochemistry and Physiology
Weber Medical Symposium, Boca Raton, FL, April 25, 2015.
[56] Sodium Nitrite: The Cure for Cardiovascular Disease
Kemin, Des Moines, IA, April 27, 2015.
[57] Nitric Oxide and Stem Cell Therapy
American Academy of Anti-Aging Medicine, Hollywood, FL, May 8, 2015.
[58] New Paradigm in the Regulation and Production of Nitric Oxide in Humans: Translating Basic Science
LSU Health Science Center, New Orleans, LA, May 11, 2015.
[59] Improving Clinical Outcomes in Vascular Disease by Enhancing Nitric Oxide Production
Professional Compounding Centers of America, Houston, TX, June 11, 2015.
[60] Nitric Oxide in Regenerative Medicine
Cell Surgical Network, Beverly Hills, CA, June 27, 2015.
[61] Chiropractic Nitric Oxide Nutrition
Fetterman Chiropractic Organization, Toledo, WI, April 18, 2015.
[62] Nitric Oxide and Sexual Function: New Discoveries and Innovations in Diagnostics and Therapeutics
American Naturopathic Medical Association, Las Vegas, NV, August 29, 2015.
[63] Chiropractic Nitric Oxide Nutrition
Fetterman Chiropractic Organization, Green Bay, WI, September 24, 2015.
[64] Chiropractic Nitric Oxide Nutrition
Fetterman Chiropractic Organization, Stevens Point, WI, April 18, 2015.
[65] Vascular Inflammation and Nitric Oxide: Bridging Diagnostics to Personalized Therapies
Cleveland Heart Lab Continuing Medical Education, August 8, 2015.
[66] Erectile Dysfunction is Endothelial Dysfunction: Understanding the Symptoms that Lead to Heart Disease
Age Management Medicine Group, Las Vegas, NV, November 6, 2015.
[67] The Role of Nitric Oxide in Regenerative Medicine
Select Biosciences, San Diego, CA, November 9, 2015.
[68] The Role of Nitric Oxide in Health and Aging: From Telomeres to Sexual Function
American Functional Medicine Association, Atlanta, GA, November 13, 2015.
[69] Chiropractic Nitric Oxide Nutrition
Fetterman Chiropractic Organization, La Crosse, WI, December 5, 2015.
[70] Inflammation and Sexual Dysfunction: Nitric Oxide as the Common Denominator
American Academy of Anti-Aging Medicine, Las Vegas, NV, December 12, 2015.
[71] The Role of Nitric Oxide in Regenerative Medicine
Cell Surgical Network, Rancho Mirage, CA, February 20, 2016.
[72] Erectile Dysfunction is Endothelial Dysfunction: Understanding the Symptoms that Lead to Heart Disease
Tennessee Osteopathic Medical Association, Chattanooga, TN, April 28 – May 1, 2016.
[73] The Role of Nitric Oxide in Regenerative Medicine
Cell Surgical Network, Beverly Hills, CA, June 4, 2016.
[74] Role of Nitrate-Reducing Oral Bacteria on Systemic Blood Pressure: Mechanisms of the Oral-Systemic Link
National Institutes of Health, NHLBI Working Group, Bethesda, MD, June 10, 2016.
[75] Nutritional Strategies for Restoration of Nitric Oxide in Humans
International and American Associations of Clinical Nutritionists, Jacksonville, FL, August 11-13, 2016.
[76] The Role of Oral Bacteria in Systemic Nitric Oxide Production in Humans: The Mechanism Behind the Oral-Systemic Link
The International Academy of Oral Medicine and Toxicology, Reno, NV, September 9-10, 2016.
[77] Dietary Nitrite and Nitrate: From Menace to Marvel – Plenary Lecture
Functional Food Conference, Harvard Medical School, Boston, MA, September 22-23, 2016.
[78] Erectile Dysfunction is Endothelial Dysfunction: Understanding the Symptoms that Lead to Heart Disease
American Functional Medicine Association, Atlanta, GA, November 10-12, 2016.
[79] The Unknown Nutrient: Discovery of the Health Benefits of Dietary Nitrate
International Conference on Food Chemistry and Technology, Las Vegas, NV, November 14-16, 2016.
[80] The Role of Nitric Oxide in Regenerative Medicine
Cell Surgical Network, Jacksonville, FL, February 2-4, 2017.
[81] The Role of Nitric Oxide in Regenerative Medicine
Academy of Regenerative Practice, Ft. Lauderdale, FL, February 24-26, 2017.
[82] The Role of the Oral Microbiota in Hypertension
American Academy of Anti-Aging Medicine, Hollywood, FL, April 7-8, 2017.
[83] Dietary Nitrite and Nitrate: From Menace to Marvel
Grocers Manufacturers Association, Washington, DC, April 20, 2017.
[84] Hypertension, Inflammation, and Nitric Oxide
Age Management Medicine Group, Orlando, FL, April 27-30, 2017.
[85] Oral Microbiome and Nitric Oxide: Mechanisms into the Oral-Systemic Link
Grand Rounds, NOVA Southeastern University, Ft. Lauderdale, FL, May 12, 2017.
[86] Clinical Applications of Nitric Oxide
Regenerative Medicine Business Summit, St. Cloud, MN, May 19, 2017.
[87] Dietary Nitrite and Nitrate: From Menace to Marvel – Keynote Lecture
International Conference on Food & Nutrition, Las Vegas, NV, May 22-24, 2017.
[88] Nitric Oxide is Required for Stem Cell Mobilization and Differentiation
Cell Surgical Network, Beverly Hills, CA, June 2-3, 2017.
[89] The Role of Nitric Oxide in Oxidative Stress & Pain
Florida Academy of Pain Medicine, Orlando, FL, June 16-18, 2017.
[90] Dietary Nitrate and Nitrite: Risk-Benefit Analysis for Human Health and Performance
International Society of Sports Nutrition, Phoenix, AZ, July 22-24, 2017.
[91] The Role of Nitric Oxide in Health and Disease – Keynote Lecture
Florida Food and Nutrition Symposium, Fort Lauderdale, FL, July 16, 2017.
[92] Oral Microbiome and Nitric Oxide: The Missing Link in the Treatment of Hypertension
American Naturopathic Medical Association, Las Vegas, NV, August 25-27, 2017.
[93] Vascular Inflammation: Cooling the Heat with Nitric Oxide
Innovision Media, Minneapolis, MN, September 22-23, 2017.
[94] The Clinical Use of Nitric Oxide in Dental Medicine
International Association of Biological Dentistry and Medicine, Houston, TX, October 19-21, 2017.
[95] The Role of Nitric Oxide in Regenerative Medicine
MedRebels Cell Therapy Training, Austin, TX, October 26-28, 2017.
[96] The Role of Nitric Oxide in Regenerative Medicine
Pacific Regenerative Medicine Conference, Honolulu, HI, November 6-7, 2017.
[97] The Role of Oral Bacteria in Gut and Brain Health
Innovision Media, Clearwater, FL, November 10-11, 2017.
[98] The Role of Nitric Oxide in Regenerative Medicine
Academy of Regenerative Practices, Weston, FL, March 2-3, 2018.
[99] Functional Nitric Oxide Nutrition – Keynote Lecture
Florida Academy of Nutrition and Dietetics, Fort Lauderdale, FL, March 10, 2018.
[100] Nitric Oxide Past, Present, and Future: Cardiovascular Implications in Adaptation to Space Travel
Grand Rounds, NASA, April 10, 2018.
[101] The Effects of Nitric Oxide on Performance and Cardiovascular Health
Sports, Cardiovascular, and Wellness Nutrition (SCAN) Conference, Keystone, CO, May 4, 2018.
[102] Nitric Oxide Overview: History of Discovery And Fundamentals of Production
WholeHealth Integration Summit: Linking Mind-Body-Mouth-Airway-Sleep – Washington DC, May 18-19, 2018
[103] Nitric Oxide is the Requisite Signal For Stem Cell Function
Cell Surgical Network, Beverly Hills, CA, June 1-3, 2018
[104] The Role of Nitric Oxide in Bio-Energetic Medicine
Tennant Institute, Dallas, TX – Sept 13-15, 2018
[105] Chiropractic Nitric Oxide Nutrition
Fetterman Education, Wassua, WI, Sept 29, 2018
[106] The Role of Nitric Oxide in Vascular Function
Worldlink Medical Congress, Oct 5-7, 2018
[107] Strategies to Optimize Regenerative Medicine Outcomes: The Role of Nitric Oxide
Med Rebels Regenerative Medicine Symposium, Austin, TX, Oct 25-27, 2018
[108] The Role of Nitric Oxide in the Treatment and Prevention of Chronic Disease
Can Chronic Disease be Reversed Medical Conference, Orlando, FL, Feb 1-2, 2019
[109] Strategies to Optimize Regenerative Medicine Outcomes: The Role of Nitric Oxide
Academy of Regenerative Practices, Westin, FL, March 22-23, 2019
[110] How Not to Die From Cardiovascular Disease: My Story of Discoveries and Life Lessons Learned Along The Journey
Burleson County Chamber of Commerce Keynote Lecture, Caldwell, TX, April 12, 2019
[111] How Not to Die From Cardiovascular Disease: My Story of Discoveries and Life Lessons Learned Along The Journey
Washington County Chamber of Commerce Keynote Lecture, Caldwell, TX, June 5, 2019
[112] Strategies to Optimize Regenerative Medicine Outcomes: The Role of Nitric Oxide
Breakthrough Discoveries in Regenerative Medicine, Beverly Hills, CA, June 22, 2019
[113] Strategies to Optimize Regenerative Medicine Outcomes: The Role of Nitric Oxide
Aesthetic Conference, Las Vegas, NV, July 11-14, 2019
[114] Physiology and Supplementation of Nitric Oxide for the Treatment of Peripheral Neuropathy
The Association of Extremity Nerve Surgeons (AENS) 2019 Annual Symposium – Atlanta, GA, Nov 8-10, 2019
[115] Nitric Oxide and Mental Health
Keynote Address, American Academy of Anti-Aging Medicine Annual Conference, Las Vegas, NV, Dec 12-14, 2020
[116] Nitric Oxide and Chronic Disease: You Can’t Live Without It
Can Chronic Disease Be Reversed, 3rd Annual Conference, Tampa Bay, FL, Feb 13-15, 2020
[117] The Role of Nitric Oxide in Regenerative Medicine
International Cell Surgical Society, Las Vegas, NV, June 4-5, 2020
[118] The Role of Nitric Oxide in Optimal Health
Allen Family Drug, Dallas, TX, Aug 2020
[119] Functional Nitric Oxide Nutrition
Fetterman Chiropractic Organization, Milwaukee, WI, October 17, 2020
[120] Translation of Nitric Oxide Based Therapies
U.S. Neuropathy Centers, Atlanta, GA, Dec 2020
[121] The Role of Nitric Oxide in Optimal Health
Event: International Cell Surgical Society
Location: Las Vegas, NV
Date: June 3-5, 2021
[122] The Role of Nitric Oxide in Regenerative Aesthetics
Event: Aesthetics Show
Location: Las Vegas, NV
Date: July 7-11, 2021
[123] Nitric Oxide: A Natural Therapy for Chronic Disease
Event: American Naturopathic Medical Association
Location: Las Vegas, NV
Date: August 27-30, 2021
[124] Innovations in Nitric Oxide-Based Therapies for Human Disease
Event: International Academy of Oral Medicine and Toxicology
Location: Bellevue, WA
Date: September 23-26, 2021
[125] Functional Nitric Oxide Nutrition
Event: Fetterman Chiropractic Education
Date: September 25, 2021
[126] Physiology and Supplementation of Nitric Oxide for the Treatment of Peripheral Neuropathy
Event: Association of Extremity Nerve Surgeons
Location: Golden, CO
Date: November 5-7, 2021
[127] Light Therapy and Nitric Oxide: From Skin Health to Hypertension
Event: AmSpa
Location: Las Vegas, NV
Date: January 27-30, 2022
[128] Nitric Oxide as the Oral-Systemic Link: From COVID-19 to Heart Attacks
Event: International Academy of Oral Medicine and Toxicology
Location: New Orleans, LA
Date: March 3-6, 2022
[129] How to Optimize Nitric Oxide in the Human Body
Event: Biohacking Congress
Location: Las Vegas, NV
Date: March 19-20, 2022
[130] Nitric Oxide and Chronic Disease: You Cannot Live Without It
Event: Senergy Medical
Location: Dallas, TX
Date: March 24, 2022
[131] Nitric Oxide as a Prevention and Treatment of Cardiovascular and COVID-19
Event: American Osteopathic Society of Rheumatic Diseases
Location: Las Vegas, NV
Date: March 25, 2022
[132] Functional Nitric Oxide Nutrition
Event: Fetterman Chiropractic Education
Location: Milwaukee, WI
Date: April 1, 2022
[133] Nitric Oxide for the Prevention and Treatment of Cardiovascular Disease with a Splash of COVID-19
Event: Congress of Medical Excellence
Location: Dallas, TX
Date: April 3, 2022
[134] How to Optimize Nitric Oxide in the Human Body
Event: The Wellness Way
Location: Orlando, FL
Date: April 9, 2022
[135] How to Optimize Nitric Oxide in the Human Body
Event: How Do You Health
Location: Austin, TX
Date: April 22, 2022
[136] Menopause and Female Sexual Arousal Disorder
Event: American Academy of Anti-Aging Medicine
Location: Hollywood, FL
Date: April 28-30, 2022
[137] Nitrate for Athletic Performance: Understanding the How and Why
Event: Academy of Nutrition and Dietetics
Date: May 11, 2022
[138] Optimization of Ozone Therapy with Nitric Oxide
Event: American Academy of Ozonotherapy
Location: Denver, CO
Date: June 2-3, 2022
[139] The Essential Requirement of Nitric Oxide in Regenerative Medicine
Event: International Cell Surgical Society
Date: June 9-11, 2022
[140] How to Optimize Nitric Oxide in the Human Body
Event: Biohacking Congress
Location: Boston, MA
Date: June 11-12, 2022
[141] Nitric Oxide and Chronic Disease: You Cannot Live Without It
Event: Senergy Medical
Location: Dallas, TX
Date: June 23, 2022
[142] Nitric oxide as the oral systemic link: From COVID-19 to heart attacks
International Academy of Biological Dentistry and Medicine, July 9, 2022
[143] Nourishing the Skin Inside and Out with Nitric Oxide
Aesthetics Show, July 11, 2022
[144] Nitric Oxide Biochemistry and Translation to Clinical Medicine
Quicksilver Scientific, Denver, CO, Aug 30, 2022
[145] How to Optimize Nitric Oxide in the Human Body
Biohacking Congress, Miami, FL, Oct 21, 2022
[146] Nitric Oxide is Required for Cellular Regeneration
American Academy of Anti-Aging Medicine, Las Vegas, NV, Dec 9, 2022
[147] Nitric Oxide and Performance
Mr. Olympia, Las Vegas, NV, Dec 16, 2022
[148] How to Optimize Nitric Oxide in the Human Body
Biohacking Congress, Austin, TX, Feb 4, 2023
[149] Cracking the Code of Clinical Translation of Nitric Oxide Science
Keynote Lecture, Gordon Research Seminar, Ventura, CA, Feb 11, 2023
[150] Cracking the Code of Clinical Translation of Nitric Oxide Science
Gordon Research Conference, Ventura, CA, Feb 13, 2023
[151] Role of the Oral Microbiome in Maintaining Systemic Blood Pressure
Holistic Dental Association, Las Vegas, NV, March 31, 2023
[152] Nitric Oxide: Connecting Oral and Systemic Health
Integrative Dental Medicine Scholar Society, St. Petersburg, FL, April 20, 2023
[153] Nitric Oxide: Beyond Hypertension
Personalized Lifestyle Medicine Institute, Chicago, IL, April 22, 2023
[154] Nitric Oxide: The Master Regulator of Acute and Chronic Inflammation
American Academy of Anti-Aging Medicine, Orlando, FL, May 19, 2023
[155] Nitric Oxide in Regenerative Medicine
International Cell Surgical Society, Las Vegas, NV, June 1-3, 2023
[156] Biohacking your Brain and Sex Organs with Nitric Oxide
Biohacking Conference, Orlando, FL, June 22-24, 2024
[157] Nitric Oxide: Connecting Oral and Systemic Health
American Academy of Oral Systemic Health, Dallas, TX, Aug 24, 2023
[158] Importance of Nitric Oxide in Health and Disease
Raadfest, Anaheim, CA, Sept 7-10, 2023
[159] Basic Understanding of Nitric Oxide in Humans
Fetterman Chiropractic, Milwaukee, WI, Sept 22, 2023
[160] Nitric Oxide as a Hormone
American Academy of Anti-Aging Medicine Bio-Identical Hormone Replacement Symposium, Chicago, IL, Sept 30, 2023
[161] The Microbiome and Nitric Oxide: Connecting Oral and Systemic Health
Pioneering the Microbiome Symposium, Hollywood, FL, Oct 21, 2023
[162] Nitric Oxide: How to Restore Endogenous Production
Health Freedom Symposium, Scottsdale, AZ, Nov 5, 2023
[163] Better Circulation for Better Health and Safety
Truckers Health Network Symposium, Mesa, AZ, Nov 10, 2023
[164] The Synergy Between Telomerase and Nitric Oxide
American Academy of Anti-Aging Medicine, Preconference Workshop, Las Vegas, NV, Dec 13, 2023
[165] The Key to Longevity: Regulating Telomeres, Stem Cells, and Mitochondria
Las Vegas, NV, Dec 14, 2023
[166] Basic Understanding of Nitric Oxide in Humans
Fordham Page Nutrition Study Club, Washington, DC, March 1, 2024
[167] Basic Understanding of Nitric Oxide in Humans
Fetterman Chiropractic, Wasau, WI, March 2, 2024
[168] The Role of the Oral Microbiome in Regulating Systemic Blood Pressure
Holistic Dental Association, Herndon, VA, April 12, 2024
[169] Improvements in Sexual Performance and Cognition with Nitric Oxide
Changing Life and Destiny Annual Congress, Plano, TX, April 12-14, 2024
[170] The Race for Longevity Begins with the Search for Nitric Oxide
Changing Life and Destiny Annual Congress, Plano, TX, April 13, 2024
[171] Nitric Oxide Signaling to Overcome Metabolic Disease
American Academy of Anti-Aging Medicine, West Palm Beach, FL, May 5, 2024
[172] Nitric Oxide, Blood Pressure, and Totality of Care
Integrative Dental Medicine Scholar Society, Knoxville, TN, May 18, 2024
[173] Biohacking Your Brain and Sex Organs with Nitric Oxide
Biohacking Conference, Dallas, TX, May 30, 2024
[174] Nitric Oxide in Regenerative Medicine
International Cell Surgical Society Conference, Las Vegas, NV, June 8, 2024
[175] Dentistry’s Role in Regulating Nitric Oxide and Blood Pressure
American Dental Association, Chicago, IL, June 21, 2024
[176] Nitric Oxide: The Foundation for Longevity and Optimal Health
RaadFest, Anaheim, CA, Sept 6, 2024
[177] Nitric Oxide As A Hormone: Understanding How to Replace a Missing Gas
American Academy of Anti-Aging Medicine, Los Angeles, CA, Sept 20, 2024
[178] Enhance IV Therapy and Cellular Uptake with Nitric Oxide
American Academy of Anti-Aging Medicine, Boston, MA, Oct 24, 2024
[179] Basic Mechanisms of Nitric Oxide Production and Signaling
American Academy of Anti-Aging Medicine Preconference Workshop, Las Vegas, NV, Dec 12, 2024
[180] Strategies to Restore Nitric Oxide Production
American Academy of Anti-Aging Medicine Preconference Workshop, Las Vegas, NV, Dec 12, 2024
[181] Longevity and Health Span Begins in the Mouth
American Academy of Anti-Aging Medicine, Las Vegas, NV, Dec 13, 2024
Meeting Presentations
International Presentations & Lectures
[1] Detection of Basal Levels of N-Nitrosamines and S-Nitrosothiols Throughout the Organ System
International Conference on Nitric Oxide, Prague, Czech Republic, June 2002.
[2] Arginosuccinate Lyase is an Essential Regulator of Nitric Oxide Production
Nitric Oxide Gordon Conference, Barga, Italy, March 1-6, 2009.
[3] Metagenomic Analysis of Bacteria from Human Tongue Scrapings Reveals Novel Bacterial Communities that Contribute Nitrite and Nitric Oxide to the Host
International Nitric Oxide Conference, Edinburgh, Scotland, July 22-26, 2012.
[4] Emerging Health Benefits of Nitrite and Nitrate: A Change in Paradigm
International Congress on Meat Science and Technology, Montreal, Canada, August 12-17, 2012.
National Presentations & Lectures
[1] On the Occurrence of Endogenous Nitros(yl)ation Products in Blood and Tissue
Experimental Biology Conference, San Diego, CA, April 2003.
[2] Vitamin C Deficiency Evokes Redox Signaling via Nitrite
Society for Free Radical Biology and Medicine Meeting, Austin, TX, November 2005.
[3] A NObonomic Approach to Unraveling Complex Nitric Oxide Biology
Department of Integrative Biology and Pharmacology, The University of Texas Houston Medical School – Department Seminar Series, November 2006.
[4] Alterations in Dietary Nitrite Modulate the Severity of Ischemia-Reperfusion Injury
Society for Free Radical Biology and Medicine Meeting, Denver, CO, November 2006.
[5] Dietary Nitrite Supplementation Restores NO/Nitroso Homeostasis in Endothelial Dysfunction and Atherosclerosis
Second International Meeting on the Role of Nitrite in Physiology, Pathophysiology, and Therapeutics, Bethesda, MD, September 2007.
[6] Dietary Nitrite and Nitrate Contribute to Cardiovascular Health and Disease
UT Houston Institute of Molecular Medicine Seminar Series, October 2007.
[7] Novel Strategies to Replete NO Homeostasis: Emerging New Paradigms
UT Health Science Center, Institute of Molecular Medicine, October 9, 2009.
[8] Concentration and Stage-Specific Effects of Nitrite on Colon Cancer
American Institute for Cancer Research, Washington, DC, October 2010.
[9] Concentration and Stage-Specific Effects of Nitrite on Colon Cancer
Society for Free Radical Biology and Medicine Conference, Orlando, FL, November 17-21, 2010.
[10] Novel Combination of Beet Root and Hawthorn Promotes Nitric Oxide Production and Lowers Triglycerides in Humans
Seventh International Conference on Functional Foods for Chronic Disease, Dallas, TX, December 3-4, 2010.
[11] Unique Combination of Beet Root and Hawthorn Berry Promotes Nitric Oxide Production and Lowers Triglycerides in Humans
Experimental Biology Meeting, Washington, DC, April 10, 2011.
[12] Nitric Oxide and Diabetes: Cause and Effect
American Academy of Anti-Aging Medicine – Continuing Medical Education, Orlando, FL, May 18-19, 2012.
[13] The Implications of Nitric Oxide Production and its Relation to Cardiovascular Health
International Academy of Oral Medicine and Toxicology, Minneapolis, MN, September 21-22, 2012.
[14] ATP Energy Production is Linked to Nitric Oxide – The Importance for Sexual and Exercise Performance
20th Annual World Congress on Anti-Aging and Aesthetic Medicine, Orlando, FL, April 11-13, 2013.
[15] Nitrite and Insulin Signaling
Fifth International Nitrite and Nitrate Meeting, Pittsburgh, PA, May 4-6, 2013.
[16] The Role of Nitric Oxide in Cellular Aging: Telomeres, Mitochondria & Stem Cells
American Academy of Anti-Aging Medicine, Las Vegas, NV, December 13-15, 2013.
[17] The Role of Nitric Oxide in Inflammation, Arthritis & Pain Mediation
Florida Chiropractic Association, Destin, FL, February 7-8, 2014.
[18] Revolutionary Advancements in Nitric Oxide
Integrative Healthcare Symposium, New York, NY, February 20-22, 2014.
[19] The Therapeutic Effects of a Nitric Oxide-Generating Lozenge that Utilizes Natural Product Chemistry
International Nitric Oxide Conference, Cleveland, OH, June 19, 2014.
[20] Therapeutic Effects of a Nitric Oxide-Generating Lozenge that Utilizes Natural Product Chemistry
Controversies and Advances in the Treatment of Cardiovascular Disease – The Fourteenth in the Series, Beverly Hills, CA, November 20, 2014.
[21] Therapeutic Effects of a Nitric Oxide-Generating Lozenge that Utilizes Natural Product Chemistry
30th Annual “Interventional Cardiology” Symposium, Snowmass, CO, March 5, 2015.
[22] Nitric Oxide Restoration: How to Find a Product that Works
Scripps Natural Supplement Conference, San Diego, CA, January 27, 2016.
[23] Nitrite, the Microbiome, and Blood Pressure
Nitric Oxide Gordon Conference, Ventura, CA, February 19-24, 2017.
[24] The Oral Microbiome and Hypertension
Experimental Biology, APS, San Diego, CA, April 22, 2018.
[25] Natural Product Chemistry and Nitric Oxide Production: New Strategies for NO-Based Therapeutics
Experimental Biology, ASPET, San Diego, CA, April 22, 2018.
[26] Evidence for Consideration of Dietary Guidelines for Nitrite and Nitrate – Session Chair
Functional Food Conference, San Diego, CA, April 24, 2018.
[27] The Contribution of Oral Anaerobes to Hypertension: Is There NO Link?
The 14th Biennial Congress of the Anaerobe Society of the Americas, Las Vegas, NV, July 9-12, 2018
[28] Dietary Nitrite and Nitrate: From Menace to Marvel
Symposium: Is It Time to Change the Paradigm for Food Toxicology? Nitrate as a Case Study, Institute of Food Technology Annual Meeting, Chicago, IL, July 17, 2018
[29] Nitric Oxide and Heart Disease: New Discoveries and Innovations in Diagnostics and Therapeutics
Annual Biotechnology Congress, Vancouver, BC, July 23, 2018
[30] Nitric Oxide is the Requisite Signal for Stem Cell Function
American Association of Stem Cell Physicians, Miami, FL, August 10-12, 2018
[31] Inherent Inefficiencies of Nitrate and Nitrite Reduction to NO Limit Their Therapeutic Utility
Nitric Oxide Gordon Conference, Ventura, CA, February 3-8, 2019
[32] Strategies to Optimize Regenerative Medicine Outcomes: The Role of Nitric Oxide
American Association of Ozonotherapy, Denver, CO, May 2-4, 2019
[33] Evidence for Use of Functional Nitric Oxide Nutrition in Primary Care
Functional Food Center Conference, San Diego, CA, May 9-10, 2019
[34] Strategies to Optimize Regenerative Medicine Outcomes: The Role of Nitric Oxide
American Academy of Anti-Aging Medicine, Orlando, FL, May 16-19, 2019
[35] Nitric Oxide Functionality in Cellular Regeneration
International Cell Surgical Society Annual Meeting, Beverly Hills, CA, May 31 – June 2, 2019
[36] Nitric Oxide Functionality in Cellular Regeneration
The Aesthetics Show, Las Vegas, NV, July 11-14, 2019
Meeting Organizer
Third International Meeting on the Role of Nitrite Physiology, Pathophysiology and Therapeutics,
June 2009, Stockholm Sweden
Fourth International Meeting on the Role of Nitrite Physiology, Pathophysiology and Therapeutics
May 2011, Atlanta GA
10th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
Sept 16-20, 2018, Oxford UK
14th International Conference of the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
April 22,27, 2026; Austin, TX
Media Events
Television Appearances
KTRK ABC Houston – TV interview with Health Correspondent Christi Myers, November 2007.
CNN – Telephone interview with Health Correspondent Elizabeth Cohen, December 2007.
Feedstuff – TV interview with Trent Loos, April 2008.
KTRK ABC Houston – TV interview with Health Correspondent Christi Myers, October 2010.
Feedstuffs – TV interview with Sarah Muirhead, December 2010.
KTBC FOX Austin – TV interview, April 2011.
KENZ ABC San Antonio – TV interview with Wendy Rigby, May 2011.
Media Training – 2012.
PBS – Healing Quest TV series, August 2013.
iHealthTube – December 2014.
Immortality Now – May 2015.
Intellectual Property
Issued Patents
Dozens of issued US Patents
Canada Issued patent
New Zealand issued patent
Mexico issued patent
Korea issued patent
6 patents pending worldwide
Business Ventures
- Stock Owner & Advisor – SAJE Pharma
- Founder, CEO – Pneuma Nitric Oxide, LLC (N1O1)
- Founder, CEO – Nitric Oxide Innovations, LLC
- Founder, CEO – Bryan Nitriceuticals, LLC (NO2U)
- Founder, CEO – Nitric Oxide Research Institute, LLC
- Founder, Chairman CEO – Bryan Therapeutics, Inc.
