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Nitric Oxide Support for Perimenopause & Menopause

★★★★★ Read customer reviews

Support Circulation Through Every Stage of Menopause

Estrogen helps your blood vessels make nitric oxide, the molecule that keeps blood flowing. As estrogen shifts in perimenopause and menopause, nitric oxide production can shift with it. N1o1 Nitric Oxide Lozenges, developed by Dr. Nathan S. Bryan, are formulated to support your body’s natural nitric oxide production.

Key Benefits May Support:

  • Healthy blood flow and circulation
  • Cardiovascular wellness
  • Everyday energy and stamina
  • Cognitive function
  • Healthy aging, with a hormone-free formula

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Menopause Changes More Than Hormones.

Hormones get most of the attention during perimenopause and menopause. They shouldn’t get all of it. As Dr. Nathan Bryan puts it, healthy aging goes beyond a single system: blood flow, circulation, sleep, nutrition, and nitric oxide all matter.

Nitric oxide helps control blood flow and tissue oxygenation. Estrogen is one of the signals that helps your blood vessels produce it, so when estrogen declines, nitric oxide production can decline too. N1o1 Nitric Oxide Lozenges release nitric oxide as they dissolve in your mouth and are formulated to support your body’s own nitric oxide production over time. They contain no hormones.
nitric oxide for health and wellness

Nitric Oxide Declines With Age

Research shows that by the time you reach 40, your body’s ability to produce nitric oxide can decrease by over 50%. For many women, that decline lines up with perimenopause, when estrogen begins to shift.

Lower nitric oxide can contribute to:

  • Stiffened arteries and reduced circulation
  • Reduced cognitive performance
  • Lower exercise capacity and slower recovery
  • Lower everyday energy

You don’t have to wait for menopause to support your nitric oxide levels.

Why N1o1 Lozenges Belong in Your Menopause Routine

Created by Dr. Nathan S. Bryan, who has studied nitric oxide for more than 30 years, these lozenges are formulated to support what your body makes on its own, before, during, and after menopause.

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Restore Nitric Oxide Levels Naturally

Nitric oxide is essential for maintaining healthy circulation, energy, and cardiovascular function. These lozenges help replenish your body’s nitric oxide levels effectively and safely.

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Targeted Health Support

Promotes heart health, cognitive clarity, stamina, and overall physical performance by enhancing nitric oxide production.

laboratory research health and wellness icon

Backed by Science

Developed by Dr. Nathan S. Bryan, a world-renowned nitric oxide researcher and leader in biochemistry.

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Convenient and Effective

Easy to take, fast-dissolving lozenge that works in the mouth to release Nitric Oxide, designed to fit seamlessly into your daily routine. If you have high acidity levels in your saliva, we recommend mixing baking soda with 2-3 ounces of water and swishing in your mouth for 30-60 seconds prior to taking a lozenge. This will help to alkalize and raise pH levels, therefore reducing the sensitivity to the Vitamin C.

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Long-Term Wellness Benefits

This is more than a quick boost. Clinical research has shown consistently increasing nitric oxide production can lead to lasting health benefits over time. Support your body’s natural functions with N1o1 Nitric Oxide Lozenges and experience the difference nitric oxide can make over time.

Science Backed Ingredients

essential vitamins and nutrients

164mg Vitamin C(Magnesium Ascorbate)

Provides essential antioxidant support and boosts immune health.

N1o1 Nitric Oxide Lozenges

12.8mg Magnesium(Magnesium Ascorbate)

Reduces tiredness and fatigue while supporting muscle function for optimal physical performance.

N1O1 nitric oxide nitric oxide signaling molecule

220mg N1o1 Proprietary Blend:

  • Magnesium Ascorbate
  • Sodium Nitrite
  • N1o1 Nitric Oxide Lozenges

    Stevia

    A natural ingredient known for its antimicrobial and antioxidant properties, often used to combat skin conditions like acne, reduce signs of aging, and promote overall skin health.

    N1o1 Nitric Oxide Lozenges

    Monk Fruit Extract

    A natural ingredient known for its antioxidant and anti-inflammatory properties, often used in skincare to protect against free radicals, reduce inflammation, and promote a healthy, youthful complexion.

    Nitric Oxide Daily Circulatory and Heart Health Support Lozenges by Dr. Nathan Bryan

    Other Ingredients:

    Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltodextrin, Stearic Acid, Vegetable Stearate, Food Starch - Modified, Starch, Silica, Citric Acid

    Watch & Learn

    Dr. Nathan Bryan, Dr. Sherwood, and N1o1 co-founder Susan Shaffer on nitric oxide, perimenopause, and menopause.

    Dr. Nathan Bryan
    Perimenopause, Menopause & Aging

    Dr. Nathan Bryan
    Perimenopause Education

    Susan Shaffer & Ludi Delfino
    Menopause Conversation

    Dr. Nathan Bryan
    Menopause

    Dr. Nathan Bryan & Dr. Sherwood

    Dr. Nathan Bryan
    N1o1 Lozenges & Menopause

    Dr. Nathan Bryan
    Menopause & Your Heart

    Susan Shaffer
    President and Co-Founder of N1o1

    Susan Shaffer
    President and Co-Founder of N1o1

    FAQs

    How does nitric oxide relate to menopause?

    Estrogen helps activate the enzyme your blood vessels use to make nitric oxide. As estrogen levels change during perimenopause and menopause, nitric oxide production can decline. Nitric oxide supports blood flow, circulation, and tissue oxygenation throughout the body. Read more in Nitric Oxide Benefits for Women.

    No. Each lozenge contains Vitamin C and magnesium (as magnesium ascorbate), the N1o1 proprietary blend (magnesium ascorbate and sodium nitrite), stevia, and monk fruit extract. N1o1 is not hormone therapy and does not replace any treatment your doctor recommends.

    If you take hormone therapy or prescription medication, or have a health condition, talk with your healthcare provider before adding N1o1. N1o1 Lozenges can be taken alongside N.O. Beetz.

    Nitric oxide production declines with age, and for many women that decline overlaps with perimenopause. As Dr. Bryan says, you don’t have to wait for menopause to invest in your health.

    Simply dissolve one N1o1 Nitric Oxide Lozenge in your mouth as directed. Move the lozenge slowly around the mouth.  It will take 5-6 minutes for the lozenge to completely dissolve.  This quick and convenient method helps maximize nitric oxide levels for consistent wellness benefits. For best use, we recommend taking one lozenge, twice a day, 12 hours apart.

    For those with high saliva acidity, we recommend swishing a mixture of baking soda and 2-3 ounces of water in your mouth for 30-60 seconds before taking the lozenge. This simple step helps alkalize and balance pH levels, reducing sensitivity to Vitamin C and enhancing your experience.

    Each bottle holds 60 lozenges. The Lozenges Bundle is four bottles for the price of three, the better value if you plan to take them daily. Both are available with Subscribe & Save on the product page.

    Dr. Nathan Bryan Dr. Nathan Bryan nitric oxide researcher

    MEET THE FOUNDER

    Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

    Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

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    A Pioneer in Nitric Oxide Science

    With over 30 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

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    Clinically Backed & Scientifically Proven

    His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 Nitric Oxide Lozenges you’re about to experience.

    N1O1 image nitric oxide

    On a Mission to Improve Lives

    Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

    Studies

    [1] Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
    PubMed
    Sandesh C S Nagamani, Philippe M Campeau, Oleg A Shchelochkov, Muralidhar H Premkumar, Kilian Guse, Nicola Brunetti-Pierri, Yuqing Chen, Qin Sun, Yaoping Tang, Donna Palmer, Anilkumar K Reddy, Li Li, Timothy C Slesnick, Daniel I Feig, Susan Caudle, David Harrison, Leonardo Salviati, Juan C Marini, Nathan S Bryan, Ayelet Erez, Brendan Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
    Download the PDF

    [2] The oral microbiome, nitric oxide and exercise performance
    PubMed
    Nathan S Bryan, Mia C Burleigh, Chris Easton
    Nitric Oxide Innovations, LLC, Houston, TX, USA.
    Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
    Download the PDF

    [3] Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease
    PubMed
    Nathan S Bryan
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
    Read the Study

    [4] Nitric oxide enhancement strategies
    PubMed
    Nathan S Bryan
    Department of Molecular & Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
    Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
    Download the PDF

    [5] Oral nitrite therapy improves vascular function in diabetic mice
    PubMed
    Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile
    Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
    Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
    Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
    Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
    Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA
    Download the PDF

    Reviews for N1o1 Nitric Oxide Lozenges

    Gwina Baek★★★★★

    I started school at my late 30’s. However, it was difficult to focus on studying. Then, I decided to try this and… wow, I can focus much better than before! Also when I exercise, I feel much less muscle ache. I will order my second bottle soon!

    Jennifer Castro★★★★★

    After taking the lozenge, I noticed my cognitive thinking was on point and my mood is lifted. I no longer take an energy drink in the morning that I was drinking before taking the lozenge. I feel more energized and focused!

    Amanda Bodini★★★★★

    I wasn’t expecting much at first, but these lozenges deliver. I feel clearer in the brain, and my blood flow feels more balanced—like my body’s functioning better

    Mary★★★★

    Ordering my second bottle today. I Am 76 and still work full time at a demanding job. Also working on my health via longevity research that is pouring out over last 10 years. My big issue is that in recent years I felt my focus/energy slipping. I now take Time Line urolithin A gummies and Stemregen Release formula. Am adding NO to the mix and plan to take for a while. Am feeling so much better now. Made me realize how changes can slowly sneak up on you. Am paying very careful attention now.

    MARCIA L GARY★★★★★

    I just started taking the lozenges and believe they will assist me in my health journey. If I wasn’t retired, I would buy some for a number of my family and friends. Really wonderful and effective product. Thank you Dr. Bryan.

    Read all reviews on the lozenges page

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