Maximum of 2 per order.
$119.98 — or subscribe to save 10%
In stock
1. Apply a single pump from each chamber to the palm of your hand, mix together and apply to the entire face and neck.
2. Allow to fully absorb 1-2 minutes before applying anything else.
3. Continue as a daily routine, applying morning and night to a clean face.
NOTE: Within a few seconds your face may turn a slight pink due to an increase in nitric oxide. This may last up to 5 minutes.
| Weight | .6 oz |
|---|---|
| Dimensions | 2 × 1.5 × 5.5 in |
*Individual results may vary. Everyone’s skin is unique and may respond differently to our products.
“Loss of nitric oxide production is recognized as the earliest event in the onset and progression of most, if not all, chronic diseases, including the number one killer of men and women worldwide—cardiovascular disease.” —Dr. Nathan S. Bryan
Introducing the revolutionary N1o1 Anti-Aging Serum by Dr. Nathan S. Bryan. This pioneering skincare product combines the Nobel Prize-winning discovery of Nitric Oxide with 20% Vitamin C to defy the signs of skin aging. N1o1 supports the stimulation of collagen production and revitalizes the flow of oxygen, hydration, and nutrients to your skin cells.
As we age, Nitric Oxide production decreases, contributing to skin aging. N1o1 Anti-Aging Serum helps replenish Nitric Oxide levels, directly combating the root causes of skin aging-wrinkles, dark spots, fine lines, and loss of tone and texture.
Backed by 20 years of research and proven effective in four clinical studies (Study 1, Study 2, Study 3, Study 4), our unique patent-pending formula generates Nitric Oxide molecules visible working on the skin within seconds. With regular use, most notice the disappearance of wrinkles, reduced pore size, improved skin tone and texture, increased clarity, and reduction in dark spots.
N1o1 Anti-Aging Serum-defy aging, and rediscover youthful, radiant skin.
Statements made have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Due to popular demand, limit 2 per order!
“Loss of nitric oxide production is recognized as the earliest event in the onset and progression of most, if not all, chronic diseases, including the number one killer of men and women worldwide—cardiovascular disease.” —Dr. Nathan S. Bryan
Clean ingredients
Cruelty-free
Vegan
Gluten-free
Low Sugar
Non-GMO
A powerful antioxidant known for its brightening and anti-aging properties, often used to protect against free radicals, boost collagen production, and improve skin tone and texture.
A versatile skincare ingredient that emulsifies oil and water, creating smooth formulations. It gently cleanses without irritation and improves the texture and spreadability of products, making it suitable for most skin types, including sensitive skin.
Form of Vitamin E used as an antioxidant in skincare and cosmetic products.
Water, hydroxyethylcellulose, sodium nitrite, dehydroacetic acid, benzyl alcohol, sodium sulfite, sodium metabisulfite, tetrasodium EDTA
Our serum is the only product on the market that generates nitric oxide on the surface of the skin.
There literally is no other product like this serum!
Yes, using our N1o1 Skin Serum on cleansed, dry skin, before using other products, will elevate the results you have with any other skin care product you may use.
Nitric oxide (NO) is known as the anti-aging molecule and is one of the essential molecules naturally produced in humans. This simple molecule regulates cellular communication by aiding oxygen and nutrient delivery to every cell in the body. When you don’t produce enough nitric oxide, your cells can’t maintain optimal health and start to malfunction.
Cells malfunction or age when they do not get enough oxygen and nutrients. Skin cells are no different.
Healthy cells are hydrated and have sufficient collagen. However, unhealthy cells lose collagen and hydration, creating fine lines and wrinkles on the skin.
Nitric oxide helps the body provide nutrients and oxygen so the skin cells can restore their function.
This includes collagen deposition, improved hydration, the loss of fine lines and wrinkles, and improved skin tone, quality, and texture.
Nitric oxide (NO) is one of the most important molecules produced in the human body.
NO is a potent vasodilator that keeps your arteries open and blood flowing to every cell in your body.
Nitric oxide is made by every cell in your body; however, production declined by 10-12% per decade starting in the early 20s. By age 40-50, we make only 50%.
Loss of NO production is associated with the normal aging process.
Increasing the nitric oxide in your system has been shown to dilate blood vessels and recruit new blood vessels, improving circulation to regions as it is produced or supplied.
Nitric oxide has potent anti-inflammatory properties that help combat free radicals that damage cells and cause premature aging.
Nitric oxide is responsible for cellular energy production and cell metabolism that keeps cells healthy and functional.
We offer USPS Priority, USPS Ground Advantage, FedEx and DHL. Most packages delivering to addresses in the US arrive in 3-4 days from shipping depending on which option you choose when ordering.
“Free Shipping” options for US shipping only typically go by USPS Ground Advantage.
An email with tracking for your order is sent when the shipping label is created. If you do not see the email in your inbox, please check your spam/junk folder and add the email address to your safe sender list.
Packages are shipped the same day if the order is received by noon Central Time Zone, as long as there are no issues with the address information provided.
[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
Annals of Plastic & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF
[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF
[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF
[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF
[5] A Novel Combination Therapy in Aesthetic and Reconstructive Surgery: Sea Salt Exfoliation, Cavitating Ultrasound, and High Intensity Multiwavelength LED Treatment: (SaltFacial)
Sciforschen Journal of Clinical and Cosmetic Dermatology
Greg Chernoff, BSc, MD, FRCSC*
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF
AS SEEN IN
Eileen A. (Verified Purchase) –
Because of stress, I get patches of red and dry skin on either side of my nostrils. My dermatologist prescribed medication and it works ok, sometimes, but when it does work the healing is slow. I put N1o1 on the red scaly patches and they heal much faster. Since using N1o1, my skin is clear
Mary T. (Verified Purchase) –
I used N1o1 for three months and my skin never looked better. Foolishly I stopped. Within two days, I noticed my skin texture had changed and the radiance of my skin became dull again. I started N1o1 again and my skin looks great.
Sue (Verified Purchase) –
My skin overall has a better texture and a healthier glow. I have never been very consistent with my beauty routine due to my busy schedule, but the results from N1o1 have inspired me to use the product regularly. I don’t want to stop using this product. It is the one beauty product I won’t skip.
Gia A. (Verified Purchase) –
I am using Pneuma currently, so that’s how I know about it. It is simply the most transformative skincare product I’ve ever used!
Suzanne S. (Verified Purchase) –
My overall skin texture has greatly improved. My pores appear smaller, the skin color is more healthy-looking, my wrinkles are less noticeable. For 57, not bad. I don’t feel the need to put on makeup other than my under-eye bags and mascara. I feel younger.
Jan M. (Verified Purchase) –
After the second day of using N1o1, I saw a huge difference in my skin. It appeared brighter and clearer. It has become my daily go-to beauty treatment that has continued to improve fine lines and wrinkles as well as the overall texture. I love this product and will never stop using it!”
Robert M. (Verified Purchase) –
Being a guy, I don’t like using products that have a strong fragrance. Pneuma has very little. I get shaving burn daily. Pneuma helped soothe my irritated skin and gave me an airbrushed complexion. I’d recommend it to any guy who just wants to look better”
Laurie H (Verified Purchase) –
N1o1 Nitric Oxide Activating Serum makes aging less daunting because now when I look in the mirror…I see radiance”
Rebecca R. (Verified Purchase) –
I have tried all kinds of cosmetics for my wrinkles and this works better than any of them
Jan C (Verified Purchase) –
I absolutely love this product! Very quickly after the first 3 days, I saw an immediate change in my skin texture. It seemed brighter and more moisturized. There was a slight redness that went away after a few days around the cheeks. I assured myself that was the ingredients working. Hurrah! I love the dual canister and combining the ingredients as my belief is they are more intense when combined right before application. After 3 weeks I went to a salon and had a facial. The technician said she had never seen such beautiful skin. She saw NO dryness on my skin and told me my pores were all perfect size. If she didn’t know me she felt my skin looked 50 and I am 64 years old!! Thank you for creating this beautiful product!
Kari M (Verified Purchase) –
THE BEST! I love this product. I have never in my life used a skin care product that made such a difference on my skin. I have a friend that also uses it and I can see a visable difference in her skin.
Ben L (Verified Purchase) –
I have recently purchased your nitric oxide product for the first time and wanted to provide some feedback. I have a severe case of Keratotis Pilaris and this product has worked wonders for me in ways I never could have imagined, and exceeded my expectation by a long shot. It is clearing up KP faster than anything else has before. KP is not known to have a cure in the medical world and almost any dermatologist would tell you there is no cure, but this product seems to be the answer. I also use this in conjunction Ammonia Oxidizing bacteria and a cream with Urea. The AOB combined with Urea creates a nitric oxide of its own on top of your product but its clear your Nitric oxide is much more potent. Anyways I would like to thank you for creating this product as i feel it is revolutionary.
Gwina Baek –
I have been using this product for 2weeks and I can feel and see the differences.
I live is Singapore which is very humid. For this weather, it is not easy to find light but effective anti aging product. So far, it clears my clogged pore and working on my fine lines. Even my husband asked what I changed. I am using with retinol and I feel that this serum work well with retinol. Somehow, it helps retinol works faster(I feel). I will definitely order second bottle! Thanks!
Leon Manko –
I use the cardio smile toothpaste, the skin serum, the lozenge and the NO Beetz every day according to the instructions.
I’ve been taking the skin serum for about a total of 8 weeks appx and it’s really amazing stuff. First thing I used the skin serum for was around the nose and mustache to fight the eczema I get often in that area. After about 4-6 weeks of daily morning use right in that spot my family, friends and I noticed the mustache area changing color back to my old hair color before I went gray.
After noticing this unexpected and remarkable effect I doubled down on my daily committment and for the last month appx have been applying the skin serum to my entire scalp and face and center of my chest where my chest hair has turned gray. The hair is changing color in all those areas only and seems thicker and healthier in some spots like on the top of my head where the hair had been thinning.
I think the nitric oxide is rejuvenating the hair follicles and allowing them to produce the normal hair color again.
The skin serum does work to keep the eczema at bay, and the skin really does look healthier and more youthful for sure.
But it’s the hair color change that has me committed to seeing how far this can go.
What would you pay for your old hair color again? Even hair dye isn’t free. The frequent use of the skin serum isn’t cheap but it’s working incredible so it’s worth every penny to me.
Not a paid review. Just a really satisfied client.
Let me know when the new products you’re developing are available so I can try them too.
Thanks Dr. Bryan.
Jennifer –
I have been using the serum for over a month now and I absolutely LOVE it. I use it in conjunction with the moisturizer. The soft skin I remember from pre-college has returned, and this serum has helped tremendously with my large pores and uneven skin pigmentation. I use one pump from each nozzle and mix it in the palm of my hand with my fingers until I see tiny bubbles form around the edge. Then I apply generously to one side of my face and then the other and allow the product to dry (a few seconds) before applying the moisurizer. Such a beautiful product. Yes, it is expensive, but to me, it’s worth the price ❤️
Chris Murphy (verified owner) –
I’ve been using this serum for a few weeks now, and I swear my skin looks brighter and feels smoother. That subtle glow every morning? Totally worth it.
Lucas Baxter (verified owner) –
At first, I thought the slight pink tint after applying meant it wasn’t for me—but then I learned that’s the serum activating nitric oxide. Now, it’s like a gentle wake-up for my skin
Jeff Doughty (verified owner) –
The dual‑pump routine feels a bit fancy, but it’s so quick—just mix and go. My pores seem tighter, and my complexion just looks… healthier.
Paul Sawyer (verified owner) –
I love that it combines Vitamin C with nitric oxide. My skin looks less dull and even in tone—I’ll keep using it day and night.
Aaron Abrams (verified owner) –
I’ve tried countless anti-aging serums, but this one really feels different. It’s like you’re giving your skin a mini reboot
Larissa Sawyer (verified owner) –
After 2 months of trying this serum, i can say that I am 100% satisfied with the results. I didnt notice a big immediate change, but over time I began to see the gentle bounce in my skin come back.
Vince –
My father (89) recently got some sever burns on his hand. It was suggested to me (by a nurse) that the serum my wife had would be great on the burn due to the nitric oxide boosting properties. She said the increased circulation result would speed up the healing. So he tried it…. The results were amazing. It did indeed speed up the healing process, significantly. Give it a try the next time you have a burn if you have some around. 🙂
Derrick R –
This serum is absolutely amazing. I’ve tried a ton of different skincare products but this is the first one where I’ve seen a real improvement in my skin.
Sonia –
I’ve been using this for about a month now. I always worry if a product will really deliver. This one does. The skin on my face is smooth and bright and my pores are much smaller. As a bonus, I decided to use the backs of my hands as the mixing area to see if the unsightly wrinkles there would look better by having the serum on them. They do look better! I don’t feel like my hands look as old as before.