Real Customers, Real Results
Denise (Age: 64)
★★★★★
- Reduce fine lines
Allison (Age: 25)
★★★★★
- Rejuvenated Skin
Trish (Age: 34)
★★★★★
- Minimize pores & blemishes
Better Skin in 3 Simple Steps
1. Apply a single pump from each chamber to the palm of your hand, mix together and apply to the entire face and neck.
2. Allow to fully absorb 1-2 minutes before applying anything else.
3. Continue as a daily routine, applying morning and night to a clean face.
NOTE: Within a few seconds your face may turn a slight pink due to an increase in nitric oxide. This may last up to 5 minutes.
“Loss of nitric oxide production is recognized as the earliest event in the onset and progression of most, if not all, chronic diseases, including the number one killer of men and women worldwide—cardiovascular disease.” —Dr. Nathan S. Bryan
Why Choose N1o1 Serum?
Introducing the revolutionary N1o1 Anti-Aging Serum by Dr. Nathan S. Bryan. This pioneering skincare product combines the Nobel Prize-winning discovery of Nitric Oxide with 20% Vitamin C to defy the signs of skin aging. N1o1 supports the stimulation of collagen production and revitalizes the flow of oxygen, hydration, and nutrients to your skin cells.
As we age, Nitric Oxide production decreases, contributing to skin aging. N1o1 Anti-Aging Serum helps replenish Nitric Oxide levels, directly combating the root causes of skin aging-wrinkles, dark spots, fine lines, and loss of tone and texture.
Backed by 20 years of research and proven effective in four clinical studies (Study 1, Study 2, Study 3, Study 4), our unique patent-pending formula generates Nitric Oxide molecules visible working on the skin within seconds. With regular use, most notice the disappearance of wrinkles, reduced pore size, improved skin tone and texture, increased clarity, and reduction in dark spots.
N1o1 Anti-Aging Serum-defy aging, and rediscover youthful, radiant skin.
Learn More
N1o1 Nitric Oxide Activating Face Serum | Revolutionary Anti-Aging & Hydrating Formula | Wrinkle & Dark Spot Reducer | Pore Minimizer & Skin Texture Enhancer | Dr. Nathan S. Bryan | 1 Fl Oz, 30ml
- Innovative Nitric Oxide Serum: Brought to you by Dr. Nathan S. Bryan, our groundbreaking N1o1 face serum, supported by numerous clinical trials, may dramatically reduce the appearance of wrinkles in under a month, enhance skin elasticity, and smoothen your complexion. It’s the FIRST skincare solution that uses Nitric Oxide, a Nobel Prize-winning discovery, to directly tackle the cause of aging skin.
- Potent Anti-Aging Benefits: The N1o1 serum supports collagen production and replenishes the flow of oxygen, hydration, and essential nutrients to your skin cells. This powerhouse formula works to reduce wrinkles, fine lines, and may support significantly improved skin tone & texture.
- Nobel Prize-Winning Innovation: Our N1o1 Anti-Aging Serum is an innovative skincare solution that harnesses the power of Nitric Oxide, a Nobel-Prize winning molecule by addressing the underlying causes of skin aging at a cellular level, such as wrinkles, collagen loss, and dehydration.
- Effortless Skincare Routine: Our serum is simple to use. Each bottle delivers up to 70 applications. Mix a single pump from each chamber in your palm and apply it to your face and neck. Allow 1-2 minutes for full absorption before using other facial products. Use both morning and night for optimal results.
- Proven Results: Supports the disappearance of wrinkles, dark spots, and the improvement of skin tone with regular use. Your skin will not can look healthier and feel more youthful! Our formula’s effectiveness is backed by 20 years of research and confirmed in four Clinical Studies.
Statements made have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Due to popular demand, limit 1 per order!
“Loss of nitric oxide production is recognized as the earliest event in the onset and progression of most, if not all, chronic diseases, including the number one killer of men and women worldwide—cardiovascular disease.” —Dr. Nathan S. Bryan
Clean ingredients
Cruelty-free
Vegan
Gluten-free
Low Sugar
Non-GMO
Frequently Asked Questions
How do I use the N1o1 Age Defiance Serum
- Apply the cleanser to your skin, cleanse the skin, rinse and dry.
- Mix one pump from each chamber of the Serum in the palm of your hand. Apply to dry skin allowing serum to dry completely. (typically about 60-90 seconds)
- Continue as a daily routine, applying morning and night to a clean face.
How is this different from other skin serums?
Our serum is the only product on the market that generates nitric oxide on the surface of the skin.
There literally is no other product like this serum!
Can I use N1o1 Serum with my other products?
Yes, using our N1o1 Skin Serum on cleansed, dry skin, before using other products, will elevate the results you have with any other skin care product you may use.
What Is Nitric Oxide?
Nitric oxide (NO) is known as the anti-aging molecule and is one of the essential molecules naturally produced in humans. This simple molecule regulates cellular communication by aiding oxygen and nutrient delivery to every cell in the body. When you don’t produce enough nitric oxide, your cells can’t maintain optimal health and start to malfunction.
How Nitric Oxide Loss Affects Your Skin?
Cells malfunction or age when they do not get enough oxygen and nutrients. Skin cells are no different.
Healthy cells are hydrated and have sufficient collagen. However, unhealthy cells lose collagen and hydration, creating fine lines and wrinkles on the skin.
Nitric oxide helps the body provide nutrients and oxygen so the skin cells can restore their function.
This includes collagen deposition, improved hydration, the loss of fine lines and wrinkles, and improved skin tone, quality, and texture.
Why is Nitric Oxide important?
Nitric oxide (NO) is one of the most important molecules produced in the human body.
NO is a potent vasodilator that keeps your arteries open and blood flowing to every cell in your body.
Nitric oxide is made by every cell in your body; however, production declined by 10-12% per decade starting in the early 20s. By age 40-50, we make only 50%.
Loss of NO production is associated with the normal aging process.
Increasing the nitric oxide in your system has been shown to dilate blood vessels and recruit new blood vessels, improving circulation to regions as it is produced or supplied.
Nitric oxide has potent anti-inflammatory properties that help combat free radicals that damage cells and cause premature aging.
Nitric oxide is responsible for cellular energy production and cell metabolism that keeps cells healthy and functional.
How quickly will my order ship?
We offer USPS Priority, USPS Ground Advantage, FedEx and DHL. Most packages delivering to addresses in the US arrive in 3-4 days from shipping depending on which option you choose when ordering.
“Free Shipping” options for US shipping only typically go by USPS Ground Advantage.
An email with tracking for your order is sent when the shipping label is created. If you do not see the email in your inbox, please check your spam/junk folder and add the email address to your safe sender list.
Packages are shipped the same day if the order is received by noon Central Time Zone, as long as there are no issues with the address information provided.
Science Backed Ingredients
Ascorbic Acid
A powerful antioxidant known for its brightening and anti-aging properties, often used to protect against free radicals, boost collagen production, and improve skin tone and texture.
Polysorbate 20
A versatile skincare ingredient that emulsifies oil and water, creating smooth formulations. It gently cleanses without irritation and improves the texture and spreadability of products, making it suitable for most skin types, including sensitive skin.
d-Tocopheryl Acetate
Form of Vitamin E used as an antioxidant in skincare and cosmetic products.
Other Ingredients
Water, hydroxyethylcellulose, sodium nitrite, dehydroacetic acid, benzyl alcohol, sodium sulfite, sodium metabisulfite, tetrasodium EDTA
Eileen A. (Verified Purchase) –
Because of stress, I get patches of red and dry skin on either side of my nostrils. My dermatologist prescribed medication and it works ok, sometimes, but when it does work the healing is slow. I put N1o1 on the red scaly patches and they heal much faster. Since using N1o1, my skin is clear
Mary T. (Verified Purchase) –
I used N1o1 for three months and my skin never looked better. Foolishly I stopped. Within two days, I noticed my skin texture had changed and the radiance of my skin became dull again. I started N1o1 again and my skin looks great.
Sue (Verified Purchase) –
My skin overall has a better texture and a healthier glow. I have never been very consistent with my beauty routine due to my busy schedule, but the results from N1o1 have inspired me to use the product regularly. I don’t want to stop using this product. It is the one beauty product I won’t skip.
Gia A. (Verified Purchase) –
I am using Pneuma currently, so that’s how I know about it. It is simply the most transformative skincare product I’ve ever used!
Suzanne S. (Verified Purchase) –
My overall skin texture has greatly improved. My pores appear smaller, the skin color is more healthy-looking, my wrinkles are less noticeable. For 57, not bad. I don’t feel the need to put on makeup other than my under-eye bags and mascara. I feel younger.
Jan M. (Verified Purchase) –
After the second day of using N1o1, I saw a huge difference in my skin. It appeared brighter and clearer. It has become my daily go-to beauty treatment that has continued to improve fine lines and wrinkles as well as the overall texture. I love this product and will never stop using it!”
Robert M. (Verified Purchase) –
Being a guy, I don’t like using products that have a strong fragrance. Pneuma has very little. I get shaving burn daily. Pneuma helped soothe my irritated skin and gave me an airbrushed complexion. I’d recommend it to any guy who just wants to look better”
Laurie H (Verified Purchase) –
N1o1 Nitric Oxide Activating Serum makes aging less daunting because now when I look in the mirror…I see radiance”
Rebecca R. (Verified Purchase) –
I have tried all kinds of cosmetics for my wrinkles and this works better than any of them
Jan C (Verified Purchase) –
I absolutely love this product! Very quickly after the first 3 days, I saw an immediate change in my skin texture. It seemed brighter and more moisturized. There was a slight redness that went away after a few days around the cheeks. I assured myself that was the ingredients working. Hurrah! I love the dual canister and combining the ingredients as my belief is they are more intense when combined right before application. After 3 weeks I went to a salon and had a facial. The technician said she had never seen such beautiful skin. She saw NO dryness on my skin and told me my pores were all perfect size. If she didn’t know me she felt my skin looked 50 and I am 64 years old!! Thank you for creating this beautiful product!
Kari M (Verified Purchase) –
THE BEST! I love this product. I have never in my life used a skin care product that made such a difference on my skin. I have a friend that also uses it and I can see a visable difference in her skin.
Ben L (Verified Purchase) –
I have recently purchased your nitric oxide product for the first time and wanted to provide some feedback. I have a severe case of Keratotis Pilaris and this product has worked wonders for me in ways I never could have imagined, and exceeded my expectation by a long shot. It is clearing up KP faster than anything else has before. KP is not known to have a cure in the medical world and almost any dermatologist would tell you there is no cure, but this product seems to be the answer. I also use this in conjunction Ammonia Oxidizing bacteria and a cream with Urea. The AOB combined with Urea creates a nitric oxide of its own on top of your product but its clear your Nitric oxide is much more potent. Anyways I would like to thank you for creating this product as i feel it is revolutionary.
Gwina Baek –
I have been using this product for 2weeks and I can feel and see the differences.
I live is Singapore which is very humid. For this weather, it is not easy to find light but effective anti aging product. So far, it clears my clogged pore and working on my fine lines. Even my husband asked what I changed. I am using with retinol and I feel that this serum work well with retinol. Somehow, it helps retinol works faster(I feel). I will definitely order second bottle! Thanks!
Leon Manko –
I use the cardio smile toothpaste, the skin serum, the lozenge and the NO Beetz every day according to the instructions.
I’ve been taking the skin serum for about a total of 8 weeks appx and it’s really amazing stuff. First thing I used the skin serum for was around the nose and mustache to fight the eczema I get often in that area. After about 4-6 weeks of daily morning use right in that spot my family, friends and I noticed the mustache area changing color back to my old hair color before I went gray.
After noticing this unexpected and remarkable effect I doubled down on my daily committment and for the last month appx have been applying the skin serum to my entire scalp and face and center of my chest where my chest hair has turned gray. The hair is changing color in all those areas only and seems thicker and healthier in some spots like on the top of my head where the hair had been thinning.
I think the nitric oxide is rejuvenating the hair follicles and allowing them to produce the normal hair color again.
The skin serum does work to keep the eczema at bay, and the skin really does look healthier and more youthful for sure.
But it’s the hair color change that has me committed to seeing how far this can go.
What would you pay for your old hair color again? Even hair dye isn’t free. The frequent use of the skin serum isn’t cheap but it’s working incredible so it’s worth every penny to me.
Not a paid review. Just a really satisfied client.
Let me know when the new products you’re developing are available so I can try them too.
Thanks Dr. Bryan.