What makes the Nitric Oxide Activating Age-Defiance Serum different?
Most serums layer ingredients on the skin’s surface. N1o1 is engineered to do more—by harnessing the essential benefits of nitric oxide for truly healthy, rejuvenated skin. Nitric oxide plays a vital role in skin health by boosting microcirculation, enhancing oxygen and nutrient delivery to skin cells, and supporting the natural production of collagen. This means your skin receives what it needs for repair, resilience, and a youthful glow, all at the cellular level.
Our patent-pending, dual-chamber system keeps the core ingredients separate until the moment of use. When mixed, they create nitric oxide—a Nobel Prize-winning molecule—right on your skin. The result is visible revitalization from within, improved firmness and elasticity, and a smoother, more radiant complexion. This isn’t just another vitamin C serum; it’s a complete cellular rejuvenation system in one bottle.
Key Benefits
- Visibly Reduces Wrinkles & Fine Lines: Helps smooth and soften the appearance of expression lines and deep-set wrinkles for a younger-looking complexion.
- Refines Pores & Texture: Minimizes the look of enlarged pores and rough texture, leaving skin feeling exceptionally smooth and soft.
- Brightens & Evens Skin Tone: Diminishes the appearance of dark spots and discoloration, promoting a clear, luminous, and even-toned complexion.
- Restores Youthful Firmness: Improves the look of skin elasticity and bounce for a firmer, more lifted appearance.
- Clinically Supported Results: Doctor-formulated by Dr. Nathan S. Bryan and backed by 20 years of research and multiple clinical studies, our formula is proven to deliver transformative cosmetic results.
Why Nitric Oxide is Essential for Healthy Skin
Nitric oxide (NO) is a vital molecule naturally produced by our bodies, but declines with age, playing a crucial role in cellular communication and overall health. In skincare, it’s a game-changer. When applied topically, nitric oxide helps improve circulation and oxygen delivery to skin cells. This enhanced blood flow can lead to a more radiant complexion, improved skin tone and texture, and better absorption of other active ingredients. It supports the skin’s natural repair processes, helping to reduce the appearance of fine lines and promoting a healthy, youthful glow.
Eileen A. (Verified Purchase) –
Because of stress, I get patches of red and dry skin on either side of my nostrils. My dermatologist prescribed medication and it works ok, sometimes, but when it does work the healing is slow. I put N1o1 on the red scaly patches and they heal much faster. Since using N1o1, my skin is clear
Mary T. (Verified Purchase) –
I used N1o1 for three months and my skin never looked better. Foolishly I stopped. Within two days, I noticed my skin texture had changed and the radiance of my skin became dull again. I started N1o1 again and my skin looks great.
Sue (Verified Purchase) –
My skin overall has a better texture and a healthier glow. I have never been very consistent with my beauty routine due to my busy schedule, but the results from N1o1 have inspired me to use the product regularly. I don’t want to stop using this product. It is the one beauty product I won’t skip.
Gia A. (Verified Purchase) –
I am using Pneuma currently, so that’s how I know about it. It is simply the most transformative skincare product I’ve ever used!
Suzanne S. (Verified Purchase) –
My overall skin texture has greatly improved. My pores appear smaller, the skin color is more healthy-looking, my wrinkles are less noticeable. For 57, not bad. I don’t feel the need to put on makeup other than my under-eye bags and mascara. I feel younger.
Jan M. (Verified Purchase) –
After the second day of using N1o1, I saw a huge difference in my skin. It appeared brighter and clearer. It has become my daily go-to beauty treatment that has continued to improve fine lines and wrinkles as well as the overall texture. I love this product and will never stop using it!”
Robert M. (Verified Purchase) –
Being a guy, I don’t like using products that have a strong fragrance. Pneuma has very little. I get shaving burn daily. Pneuma helped soothe my irritated skin and gave me an airbrushed complexion. I’d recommend it to any guy who just wants to look better”
Laurie H (Verified Purchase) –
N1o1 Nitric Oxide Activating Serum makes aging less daunting because now when I look in the mirror…I see radiance”
Rebecca R. (Verified Purchase) –
I have tried all kinds of cosmetics for my wrinkles and this works better than any of them
Jan C (Verified Purchase) –
I absolutely love this product! Very quickly after the first 3 days, I saw an immediate change in my skin texture. It seemed brighter and more moisturized. There was a slight redness that went away after a few days around the cheeks. I assured myself that was the ingredients working. Hurrah! I love the dual canister and combining the ingredients as my belief is they are more intense when combined right before application. After 3 weeks I went to a salon and had a facial. The technician said she had never seen such beautiful skin. She saw NO dryness on my skin and told me my pores were all perfect size. If she didn’t know me she felt my skin looked 50 and I am 64 years old!! Thank you for creating this beautiful product!
Kari M (Verified Purchase) –
THE BEST! I love this product. I have never in my life used a skin care product that made such a difference on my skin. I have a friend that also uses it and I can see a visable difference in her skin.
Ben L (Verified Purchase) –
I have recently purchased your nitric oxide product for the first time and wanted to provide some feedback. I have a severe case of Keratotis Pilaris and this product has worked wonders for me in ways I never could have imagined, and exceeded my expectation by a long shot. It is clearing up KP faster than anything else has before. KP is not known to have a cure in the medical world and almost any dermatologist would tell you there is no cure, but this product seems to be the answer. I also use this in conjunction Ammonia Oxidizing bacteria and a cream with Urea. The AOB combined with Urea creates a nitric oxide of its own on top of your product but its clear your Nitric oxide is much more potent. Anyways I would like to thank you for creating this product as i feel it is revolutionary.
Gwina Baek –
I have been using this product for 2weeks and I can feel and see the differences.
I live is Singapore which is very humid. For this weather, it is not easy to find light but effective anti aging product. So far, it clears my clogged pore and working on my fine lines. Even my husband asked what I changed. I am using with retinol and I feel that this serum work well with retinol. Somehow, it helps retinol works faster(I feel). I will definitely order second bottle! Thanks!
Leon Manko –
I use the cardio smile toothpaste, the skin serum, the lozenge and the NO Beetz every day according to the instructions.
I’ve been taking the skin serum for about a total of 8 weeks appx and it’s really amazing stuff. First thing I used the skin serum for was around the nose and mustache to fight the eczema I get often in that area. After about 4-6 weeks of daily morning use right in that spot my family, friends and I noticed the mustache area changing color back to my old hair color before I went gray.
After noticing this unexpected and remarkable effect I doubled down on my daily committment and for the last month appx have been applying the skin serum to my entire scalp and face and center of my chest where my chest hair has turned gray. The hair is changing color in all those areas only and seems thicker and healthier in some spots like on the top of my head where the hair had been thinning.
I think the nitric oxide is rejuvenating the hair follicles and allowing them to produce the normal hair color again.
The skin serum does work to keep the eczema at bay, and the skin really does look healthier and more youthful for sure.
But it’s the hair color change that has me committed to seeing how far this can go.
What would you pay for your old hair color again? Even hair dye isn’t free. The frequent use of the skin serum isn’t cheap but it’s working incredible so it’s worth every penny to me.
Not a paid review. Just a really satisfied client.
Let me know when the new products you’re developing are available so I can try them too.
Thanks Dr. Bryan.
Jennifer –
I have been using the serum for over a month now and I absolutely LOVE it. I use it in conjunction with the moisturizer. The soft skin I remember from pre-college has returned, and this serum has helped tremendously with my large pores and uneven skin pigmentation. I use one pump from each nozzle and mix it in the palm of my hand with my fingers until I see tiny bubbles form around the edge. Then I apply generously to one side of my face and then the other and allow the product to dry (a few seconds) before applying the moisurizer. Such a beautiful product. Yes, it is expensive, but to me, it’s worth the price ❤️
Chris Murphy (verified owner) –
I’ve been using this serum for a few weeks now, and I swear my skin looks brighter and feels smoother. That subtle glow every morning? Totally worth it.
Lucas Baxter (verified owner) –
At first, I thought the slight pink tint after applying meant it wasn’t for me—but then I learned that’s the serum activating nitric oxide. Now, it’s like a gentle wake-up for my skin
Jeff Doughty (verified owner) –
The dual‑pump routine feels a bit fancy, but it’s so quick—just mix and go. My pores seem tighter, and my complexion just looks… healthier.
Paul Sawyer (verified owner) –
I love that it combines Vitamin C with nitric oxide. My skin looks less dull and even in tone—I’ll keep using it day and night.
Aaron Abrams (verified owner) –
I’ve tried countless anti-aging serums, but this one really feels different. It’s like you’re giving your skin a mini reboot
Larissa Sawyer (verified owner) –
After 2 months of trying this serum, i can say that I am 100% satisfied with the results. I didnt notice a big immediate change, but over time I began to see the gentle bounce in my skin come back.
Vince –
My father (89) recently got some sever burns on his hand. It was suggested to me (by a nurse) that the serum my wife had would be great on the burn due to the nitric oxide boosting properties. She said the increased circulation result would speed up the healing. So he tried it…. The results were amazing. It did indeed speed up the healing process, significantly. Give it a try the next time you have a burn if you have some around. 🙂
Derrick R –
This serum is absolutely amazing. I’ve tried a ton of different skincare products but this is the first one where I’ve seen a real improvement in my skin.
Sonia –
I’ve been using this for about a month now. I always worry if a product will really deliver. This one does. The skin on my face is smooth and bright and my pores are much smaller. As a bonus, I decided to use the backs of my hands as the mixing area to see if the unsightly wrinkles there would look better by having the serum on them. They do look better! I don’t feel like my hands look as old as before.
Rebecca R (verified owner) –
I have tried all kinds of cosmetics for my wrinkles and this N1o1 serum works better than any of them.
Jan M. (verified owner) –
After the second day of using N1o1 , I saw a huge difference in my skin. It appeared brighter and clearer. It has
become my daily go-to beauty treatment that has continued to improve fine lines and wrinkles as well as the overall
texture. I love this product and will never stop using it!
angelique s. (verified owner) –
I can’t live without my N1o1 Serum! My skin is smoother, brighter and tone has improved since I started using it. It feels so good and I can’t start or end my day without it.
Monica M. (verified owner) –
My skin is healthier and has a glow now that I didn’t have before. I get compliments on my skin and asked what I have don’t differently. So easy but the N1o1 Nitric Oxide Serum is a critical part of my skincare now.
Sharon Ting (verified owner) –
I’ve been using the N1o1 Nitric Oxide Serum for six weeks, and it’s earned a permanent spot on my shelf. As a 42-year-old with combination skin, my main concerns are fine lines, dullness around my cheeks, and breakouts. I apply it morning and night after cleansing. It absorbs almost instantly with no stickiness or pilling under my makeup and sunscreen, which is a huge plus.
Within two weeks, I noticed a subtle radiance. Now, the fine lines around my eyes look softer, and my skin tone is more even, especially around my nose and mouth. I’ve also had fewer T-zone breakouts. The only small drawback is a slight scent when you first apply it, but it fades quickly.
My tip: Apply it to slightly damp skin and store it away from heat. It’s a definite repurchase for me.
phoebe (verified owner) –
I have oily, acne-prone skin and was worried this serum would break me out, but it’s been amazing. After four weeks of nightly use, my post-acne marks look lighter and my face is much less shiny by midday. It feels lightweight and never clogs my pores. Expensive but now I can’t live without it.
Laurie H. (verified owner) –
N1o1 makes aging less daunting because now when I look in the mirror…I see radiance! Thank you Dr. Bryan