N1o1 Nitric Oxide Body & Mind Essentials

Name: N1o1 Nitric Oxide Body & Mind Essentials - N1o1 Nitric Oxide - Boost Your Health
Brand: Pneuma Nitric Oxide
SKU: BME-1-2
Availability: InStock
Rating: 5.00 (8 reviews)

Transform Your Health at a Cellular Level

As we age, our body’s natural ability to produce nitric oxide declines dramatically—a process that begins earlier than many realize. This isn’t just a small change; it affects your overall health, influencing key areas like blood circulation, energy levels, oral health, and even the tone and elasticity of your skin. Poor nitric oxide levels can lead to sluggishness, dull skin, and reduced vitality in daily life, making it harder to feel like the best version of yourself.

N1o1’s exclusive Body & Mind system is specially designed to address this decline by replenishing nitric oxide levels in your body. By restoring this essential molecule, it supports better blood flow for improved energy, contributes to healthier oral microbiome, and promotes a radiant, youthful appearance. Whether it’s feeling more energized throughout the day or noticing a refreshed glow in your skin, this solution helps you maintain vitality and confidence at every stage of life.

“Nitric oxide is considered one of the most important molecules produced in humans. This simple molecule controls oxygen and nutrient delivery to every cell in the body; it regulates cellular communication and even has anti-microbial properties that protect our body from invading pathogens. In fact, this molecule is so important it was named “Molecule of the Year” by Science Magazine in 1992 and in 1998 a Nobel Prize in Physiology or Medicine was awarded to the three US Scientists responsible for its discovery.”
— Dr. Nathan S Bryan

What's Included?

N1o1 Nitric Oxide Lozenges:

The Quick-Dissolve Boost

Experience an immediate surge of vitality with our revolutionary quick-dissolve lozenges. Perfect for on-the-go support, these lozenges are scientifically formulated to rapidly generate nitric oxide, supporting healthy circulation and blood pressure.

Instant Support: Feel the effects in minutes.
Cardiovascular Health: Promotes optimal heart function and blood flow.
Great Taste: A pleasant, easy way to boost your N.O. levels anytime, anywhere.

N.O. Beetz:

The Energizing Pre-Workout Drink
(Pre-converted for nitric oxide production)

Fuel your day and your workouts with the clean, natural power of N.O. Beetz. This delicious powdered drink mix transforms beets into a mess-free, oxalate-free, great-tasting powerhouse that enhances stamina and nutrient delivery.

Sustained Energy: Enjoy a natural energy lift without jitters or a crash.
Performance Enhancer: Improves oxygen delivery to cells for better endurance.
Supports Hydration: Improved cellular hydration with electrolytes.
Antioxidant Powerhouse: Supports your body's defense against oxidative stress.
For best use, do not take within 4 hours of the N1o1 Nitric Oxide Lozenge.

CardioSmile Nitric Oxide Toothpaste:

The Oral Health Revolution

Your oral health is the gateway to your overall well-being. CardioSmile is the first and only toothpaste designed to generate nitric oxide, supporting a healthy oral microbiome and promoting cardiovascular health.

Triple-Action Formula: Whitens teeth, remineralizes enamel, and freshens breath while supporting heart health.
Protects Oral Microbiome: Free from fluoride and other harsh ingredients that can disrupt good bacteria.
Systemic Benefits: A simple addition to your daily routine that contributes to whole-body wellness.

n1o1 nitric oxide activating serum front back

Age-Defiance Serum:

The Secret to Ageless Skin

Turn back the clock with our groundbreaking Nitric Oxide Activating Age-Defiance Serum. This is the hero skincare product that generates nitric oxide directly on your skin, visibly reducing fine lines, wrinkles, and dark spots. You can actually see your skin turn slightly pink as it’s working due to an increase of blood flow.

Cellular Rejuvenation: Stimulates collagen production and restores oxygen and nutrient flow to skin cells.
Proven Results: Backed by 5 clinical studies to improve skin tone, texture, and elasticity.
Radiant Glow: Revitalize dull, tired skin for a complexion that looks and feels more youthful and vibrant..

Essential for Health

Why Nitric Oxide is Essential for You:

As we age, our natural nitric oxide production declines, impacting energy, stamina, circulation, and even skin and oral health. N1o1 solutions are backed by Nobel Prize-winning science and over 25 years of research to:

Boost Circulation & Energy: Improve blood flow for better vitality and stamina.
Support Heart Health: Crucial for overall cardiovascular well-being.
Rejuvenate Skin: Enhance elasticity, reduce fine lines, and promote a youthful glow.
Strengthen Oral Health: Support a healthy oral microbiome and gums.
Combat Oxidative Stress: Protect your body from environmental damage.

Why the N1o1 Nitric Oxide Body & Mind Essentials is a Must-Have:

Synergistic Formulas: Designed to work together for maximum nitric oxide activation, both internally and externally.
Targeted Anti-Aging & Wellness: Optimize nitric oxide levels for improved memory, focus, heart health, physical performance, and age-defying results.
Backed by Biochemistry: Created by Dr. Nathan S. Bryan, a world-renowned nitric oxide researcher.
Biohacker Approved: Promotes healthy blood pressure, circulation, and visibly improves oral and skin health.
Science Meets Simplicity: Clean, effective, non-toxic formulas that seamlessly fit into your daily routine.
Long-Term Results: A proven routine for sustained, visible skin improvement and enhanced overall health.

How to Use

N1o1 Nitric Oxide Lozenges:

Take One N1o1 Nitric Oxide Lozenge, Twice a Day to Undo Years of Damage

Hydrate before use. Place one lozenge in the mouth, moving the tablet around over the top of the tongue as it dissolves. Once the tablet has fully dissolved, swallow the remaining saliva.

NOTE: If you have acidic saliva, alkalize your mouth by swishing with a mixture of baking soda and water before use.

*This is a dietary supplement not intended to diagnose, treat, cure, or prevent any diseases.

Ingredients

Science Backed Ingredients

N1o1 Nitric Oxide Lozenges

Key Ingredients:

Vitamin C & Magnesium (essential nutrients), NO2U™ Proprietary Blend (Magnesium Ascorbate, Sodium Nitrite for nitric oxide activation).

Full ingredient list:

Vitamin C (from Magnesium Ascorbate), Magnesium (from Magnesium Ascorbate), NO2U™ Proprietary Blend [Magnesium Ascorbate, Sodium Nitrite], Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltodextrin, Stearic Acid, Vegetable Stearate, Food Starch – Modified, Starch, Silica, Stevia, Citric Acid, Monk Fruit

N.O. Beetz

Key Ingredients:

Vitamins C & D (antioxidant, immune support), Electrolytes (Magnesium, Zinc, Manganese, Sodium, Potassium), NO2U™ Proprietary Blend, Fermented Beet Root Powder (preconverted for nitric oxide production), D-Ribose & PEAK ATP® (cellular energy).

Full ingredient list:

Vitamin C (as Ascorbic Acid), Vitamin D (as Cholecalciferol), Magnesium (as DiMagnesium Malate), Zinc (as Zinc Bisglycinate Chelate), Manganese (as Manganese Bisglycinate Chelate), Sodium, Potassium, NO2U™ Proprietary Blend, Fermented Beet Root Powder, D-Ribose, PEAK ATP® (Adenosine 5′-Triphosphate Disodium), Citric Acid, Sea Salt, Rebaudioside A (Stevia Extract), Malic Acid, Natural Flavor

CardioSmile Nitric Oxide Toothpaste

Key Ingredients:

Potassium Nitrate (sensitivity relief), Xylitol (cavity prevention), Hydroxyapatite (enamel remineralization), Zinc Citrate (plaque/gingivitis control), Essential Oils (Peppermint, Spearmint, Wintergreen, Tea Tree, Eucalyptus, Thyme for fresh breath & antiseptics).

Full ingredient list:

Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite 4 Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulgaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate

Nitric Oxide Activating Anti-Aging Serum

Key Ingredients:

Ascorbic Acid (Vitamin C, antioxidant, collagen support), Sodium Nitrite (activates nitric oxide for skin repair), d-Tocopheryl Acetate (Vitamin E, antioxidant protection).

Full ingredient list:

Water, Ascorbic Acid (Vit. C), Polysorbate 20, Hydroxyethylcellulose, Sodium Nitrite, d-Tocopheryl Acetate (Vit. E), Dehydroacetic Acid, Benzyl Alcohol, Sodium Sulfite, Sodium Metabisulfite, Tetrasodium EDTA.

FAQs

What’s happening in my body as I take the N1o1 Nitric Oxide Lozenge?

Timeline of Physiological Effects Induced by a N1o1 Nitric Oxide Lozenge

Discover what’s happening in your body when you use a N1o1 Nitric Oxide Lozenge, from its physiological effects to how it quietly supports your overall health—even if you can’t feel it.

12 Seconds – Carotid arteries begin to dilate, increasing blood flow to the brain.
1 Minute – Blood vessels dilate, enhancing circulation throughout the body.
5 Minutes – Notice a 2.1% boost in exercise performance.
10 Minutes – Carotid arteries dilate by 13%, leading to a 34% increase in blood flow to the brain and body.
20 Minutes – For individuals with elevated blood pressure (130-139/80-89 mmHg), systolic and diastolic blood pressure drops by 5-6 mmHg.
20-30 Minutes – Blood vessels become more flexible and compliant, improving vascular function by 20% and reducing arterial strain.
60 Minutes – Elevated blood pressure drops further by 8-10 mmHg, with some cases seeing reductions of up to 50-60 mmHg for extremely high readings.
4 Hours – Endothelial function improves by 15-25%, boosting natural nitric oxide production.
2 Weeks – Blood flow regulation improves, enhancing mitochondrial function and exercise capacity.
3 Weeks – Reduced oxidative stress and inflammation.
1 Month – Blood pressure in pre-hypertension and hypertension patients decreases by 12 mmHg systolic and 6 mmHg diastolic, triglycerides drop by 27%, and cardiovascular health improves.
6 Months – Existing arterial plaque stabilizes and begins to regress by 11%; endothelial function normalizes.
9 Months – Kidney function improves, protein excretion decreases, and cardiac function strengthens, including reduced cardiac hypertrophy.
12 Months – Arterial health improves, telomeres stabilize, and antioxidant defenses combat post-meal oxidative stress and inflammation. Cognitive gains include better verbal memory and problem-solving skills.

Experience the comprehensive benefits of N1o1 Nitric Oxide Lozenges and transform your cardiovascular health at every stage.

What’s happening in my body as I take N.O. Beetz?

Timeline of Benefits with N.O. Beetz

Discover how N.O. Beetz works to support your health step by step:

Within Minutes: Blood vessels begin to dilate, improving circulation and oxygen delivery.
Within Hours: Enhanced nitric oxide levels lead to better energy, stamina, and focus.
Within Weeks: Consistent use supports cardiovascular health, reduced oxidative stress, and improved endurance.
Within Months: Long-term benefits include stabilized blood pressure, reduced arterial plaque, more mitochondria per cell producing more energy more efficiently and improved overall vitality

Experience the Power of N.O. Beetz
Transform your health and performance with N.O. Beetz, the natural, science-backed solution for boosting nitric oxide levels.

What makes CardioSmile Nitric Oxide Toothpaste different from other toothpastes on the market?

CardioSmile is a first-of-its-kind toothpaste, designed to actively support your body’s nitric oxide ecosystem, beyond just cleaning teeth.

What makes it different:

Nitric oxide focus: The world’s first toothpaste supporting nitric oxide production and a healthy oral microbiome, linking oral care to whole-body circulation and cardiovascular wellness.
Fluoride free remineralization: Uses hydroxyapatite to strengthen and rebuild enamel, gentle on teeth and gums.
Oral microbiome support: Nurtures beneficial bacteria, avoids harsh antiseptics that suppress nitric oxide pathways, and maintains healthy saliva pH.
Sensitivity & tartar control: Potassium nitrate reduces sensitivity; zinc citrate, hydrated silica, and calcium carbonate control tartar and polish without aggressive abrasives.
Clean essential oils: Peppermint, spearmint, wintergreen, tea tree, and cinnamon provide natural antimicrobial breath freshening, free from chemical aftertaste.
Doctor-developed credibility: Created by leading nitric oxide researcher, Dr. Nathan S. Bryan, aligning with N1o1’s science-backed approach.

CardioSmile redefines toothpaste as a daily nitric oxide routine, supporting gum circulation, enamel health, fresh breath, and a resilient oral microbiome—all while being fluoride and harsh antiseptic-free.

What makes N1o1 Nitric Oxide Activating Age-Defiance Serum unique?

N1o1 Nitric Oxide Activating Age-Defying Skincare Serum stands out for several key reasons:

First and only nitric oxide–generating serum: Unlike conventional serums, it actively generates nitric oxide on the skin’s surface. This addresses aging at a cellular level by improving oxygen and nutrient delivery to skin cells, boosting collagen, hydration, and healthy metabolism.
Dual‑chamber activation you can see: The two-part system mixes on application, visibly activating in seconds. A brief pink flush indicates increased nitric oxide activity, a visible sign of activation.
Clinically backed outcomes: Multiple clinical studies support improvements in wrinkles, pore size, skin tone, texture, clarity, and dark spots with regular use.
Synergy with Vitamin C and antioxidants: It combines nitric oxide activation with 20% Vitamin C and Vitamin E, enhancing brightening, collagen support, and free‑radical defense for comprehensive results.
Simple, high‑impact routine: Each bottle provides up to ~70 applications. Apply one pump from each chamber, twice daily on clean skin, and allow 1–2 minutes to absorb. This makes clinical‑grade results achievable with minimal effort.
Science led by a nitric oxide pioneer: Developed by Dr. Nathan S. Bryan, a leading authority in nitric oxide biochemistry, bringing two decades of research to daily skincare.

Bottom line: This serum doesn’t just layer antioxidants; it restores nitric oxide at the skin surface to re‑energize cellular function, helping skin look and act younger.

When can I expect to see or feel results?

Many users feel an immediate sense of refreshment from the toothpaste and an energy lift from the lozenges and N.O. Beetz (it’s best to space these 4 hours apart). With consistent daily use of the Age-Defiance Serum, visible improvements in skin tone, texture, and the appearance of fine lines are often reported within 30 days.

What does a daily routine with this kit look like?

Morning: Start by brushing with CardioSmile Toothpaste. Then, apply the Age-Defiance Serum to clean skin. Use N.O. Beetz for sustained energy or a pre-workout boost.

Throughout the Day: Use a N1o1 Nitric Oxide Lozenge as needed for a quick vitality lift.

Evening: Brush with CardioSmile Toothpaste and apply the Age-Defiance Serum before bed.

Dr. Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

Studies

[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
Annals of Plastic & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF

[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF

[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF

[5] A Novel Combination Therapy in Aesthetic and Reconstructive Surgery: Sea Salt Exfoliation, Cavitating Ultrasound, and High Intensity Multiwavelength LED Treatment: (SaltFacial)
Sciforschen Journal of Clinical and Cosmetic Dermatology
Greg Chernoff, BSc, MD, FRCSC*
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[6] Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
PubMed
Sandesh C S Nagamani, Philippe M Campeau, Oleg A Shchelochkov, Muralidhar H Premkumar, Kilian Guse, Nicola Brunetti-Pierri, Yuqing Chen, Qin Sun, Yaoping Tang, Donna Palmer, Anilkumar K Reddy, Li Li, Timothy C Slesnick, Daniel I Feig, Susan Caudle, David Harrison, Leonardo Salviati, Juan C Marini, Nathan S Bryan, Ayelet Erez, Brendan Lee
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Download the PDF

[7] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF

[8] Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Download the PDF

[9] Nitric oxide enhancement strategies
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Download the PDF

[10] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile

Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

Download the PDF

8 reviews for N1o1 Nitric Oxide Body & Mind Essentials

Rated 5 out of 5

Emily S. – 12/08/2025

I bought this hoping for a little more vitality, and it delivered more than I expected. I not only have more physical energy, but I just feel a greater sense of overall wellness from head to toe. It’s a subtle but powerful change that has made a huge impact on my daily life.
Rated 5 out of 5

Chloe Shin – 12/08/2025

I’ve tried so many serums, but the Nitric Oxide Serum is the first one that has given my skin a genuine, visible glow. My complexion looks smoother, brighter, and just feels healthier. I constantly get compliments on how radiant my skin looks now. I keep N.O. Beetz in my gym bag and the Nitric Oxide Lozenges my desk drawer for when I need a quick boost before a meeting. They’re perfect for my daily routine. The convenience and dual benefits are a must have for my busy schedule.
Rated 5 out of 5

Melissa P – 12/09/2025

Since using the serum I have noticed smoother texture and a healthier glow. The toothpaste taste great and leaves my whole mouth feeling fresh all day and the supplements are amazing! Definitely recommend for a total body N.O boost.
Rated 5 out of 5

Michelle G – 12/10/2025

This mix of nitric-oxide lozenges, N.O Beetz ,Cardio Smile , and serum feels clean, easy to use, and works nicely together. I notice my daily vitality has improved and a my skin looks healthy . It’s a great choice if you a want simple way to feel and look your best as you go through your day.
Rated 5 out of 5

Beth – 12/10/2025

This bundle has got the necessities for feeling and looking my best, daily! I love starting my day off fresh with Cardiosmile toothpaste. The N.O. Beetz are my go-to for an afternoon pick-me up, replacing my old habit of energy drinks. I tell everyone I can about the benefits of these supplements.
Rated 5 out of 5

Sarah K. – 12/10/2025

I needed something to help combat my fatigue and brain fog. I used to struggle with having no energy in the afternoon. Since adding the lozenge and N.O. Beetz to my daily routine, I feel like a new person. The serum really helped improve my skin tone and texture, giving it a more youthful glow. I feel more confident than ever with better skin and mood!
Rated 5 out of 5

Sam H. – 12/10/2025

I watched Dr. Bryan speak about his nitric oxide products on Daystar and immediately ordered this bundle. The lozenge and serum have made my daily routine simpler. I appreciate that the toothpaste seems gentle yet effective, and I have the peace of mind that I am not putting dangerous chemicals in my body while taking care of my teeth. These products are a well-rounded wellness pack that works for someone like me who wants to cover a lot of bases without overthinking it.
Rated 5 out of 5

Nick B. – 12/10/2025

I recommend this bundle to all of my friends and family after seeing Dr. Bryan talk about them on youtube. The toothpaste leaves a clean, refreshed feeling, and the NO beetz give a boost to my overall health and energy. If you’re looking for a convenient all-in-one set, this one is hard to beat.

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Elevate your wellness. Reclaim your vitality. Discover the power of nitric oxide.

N1o1 Nitric Oxide Lozenges

Enhance Circulation, Vitality, and Overall Wellness

N.O. Beetz Nitric Oxide Supplement

Boost Circulation, Energy, and Overall Wellness Naturally

Nitric Oxide Activating Age-Defiance Serum

Meet the First-Ever Nitric Oxide Activating Serum

CardioSmile Nitric Oxide Boosting Toothpaste

LIMITED TIME RELEASE

Transform Your Health at a Cellular Level

What's Included?

N1o1 Nitric Oxide Lozenges:

N.O. Beetz:

CardioSmile Nitric Oxide Toothpaste:

Age-Defiance Serum:

Essential for Health

Why Nitric Oxide is Essential for You:

Why the N1o1 Nitric Oxide Body & Mind Essentials is a Must-Have:

How to Use

N1o1 Nitric Oxide Lozenges:

N.O. Beetz:

CardioSmile Nitric Oxide Toothpaste:

Nitric Oxide Activating Age-Defiance Serum:

Ingredients

Science Backed Ingredients

N1o1 Nitric Oxide Lozenges

Key Ingredients:

N.O. Beetz

Key Ingredients:

CardioSmile Nitric Oxide Toothpaste

Key Ingredients:

Nitric Oxide Activating Anti-Aging Serum

Key Ingredients:

FAQs

Dr. Bryan

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

A Pioneer in Nitric Oxide Science

Clinically Backed & Scientifically Proven

On a Mission to Improve Lives

Studies

8 reviews for N1o1 Nitric Oxide Body & Mind Essentials

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