N1o1 Body and Mind Essentials | Nitric Oxide Wellness Bundle

Name: N1o1 Body and Mind Essentials | Nitric Oxide Wellness Bundle
Brand: Pneuma Nitric Oxide
SKU: BME-1-3
Price: 247.43 USD
Availability: InStock
Rating: 5.00 (9 reviews)

Transform Your Health at a Cellular Level

As we age, the body’s natural ability to produce nitric oxide declines dramatically — and it begins earlier than most people realize. This isn’t a minor change. It influences blood circulation, energy levels, oral health, and even the tone and elasticity of your skin. Low nitric oxide can leave you feeling sluggish, looking dull, and operating below your best.

The N1o1 Nitric Oxide Body & Mind system is built to reverse that decline by replenishing nitric oxide from four directions at once — supporting better blood flow for energy, a healthier oral microbiome, and a more radiant, youthful appearance. The result is vitality and confidence you can feel and see at every stage of life.

“Nitric oxide is one of the most important molecules produced in humans. It controls oxygen and nutrient delivery to every cell, regulates cellular communication, and even protects the body from invading pathogens. It was named ‘Molecule of the Year’ by Science Magazine in 1992, and in 1998 a Nobel Prize was awarded to the three scientists responsible for its discovery.”
— Dr. Nathan S. Bryan

What's Included?

N1o1 Nitric Oxide Breath of Life Toothpaste front back transparent

Breath of Life Nitric Oxide Boosting Toothpaste:

The Oral Health Revolution

Your mouth is the gateway to your whole-body wellness. Breath of Life is the world’s first toothpaste designed to support nitric oxide production — nurturing a healthy oral microbiome instead of sterilizing it, while caring for your teeth and gums. It’s the hero of your morning and night routine.

Triple-Action Formula: Whitens, remineralizes enamel, and freshens breath while supporting heart health.
Protects the Oral Microbiome: Fluoride-free and free of harsh ingredients that disrupt the good bacteria behind nitric oxide.
Systemic Benefits: A simple daily swap that links oral care to whole-body circulation.

N1o1 Nitric Oxide Lozenges:

The Quick-Dissolve Boost

An immediate surge of vitality, formulated to rapidly generate nitric oxide for healthy circulation and blood pressure already within the normal range.

Instant Support: Feel the effects in minutes.
Cardiovascular Health: Supports optimal heart function and blood flow.
Great Taste: A pleasant, easy way to boost your levels anytime, anywhere.

For best results, always hydrate before taking any supplements such as N1o1 Nitric Oxide Lozenges.

N.O. Beetz:

The Energizing Daily Drink

Clean, natural energy from fermented beets — reimagined as a mess-free, oxalate-free, great-tasting powder, pre-converted for nitric oxide production.

Sustained Energy: Delivers clean, steady energy without jitters or crashes.
Performance Enhancer: Supports oxygen delivery and circulation for endurance, stamina, and workout efficiency.
Hydration & Protection: Electrolytes for improved cellular hydration and antioxidant defense.
Powered by Patented PEAK ATP®: Clinically studied to help increase cellular energy production, support strength and power output, enhance recovery, and improve athletic performance.
Nitric Oxide Support: Helps support healthy blood flow and cardiovascular wellness for everyday vitality.

Nitric Oxide Activating Age-Defiance Serum:

The Secret to Ageless Skin

The only serum in the world that generates nitric oxide directly on your skin. A dual-chamber formula activates on contact — you can watch your skin flush slightly pink as blood flow increases — visibly reducing fine lines, wrinkles, and dark spots.

Cellular Rejuvenation: Stimulates collagen and restores oxygen and nutrient flow to skin cells.
Proven Results: Backed by 5 clinical studies for improved tone, texture, and elasticity.
Radiant Glow: Revitalizes dull, tired skin for a complexion that looks and feels more youthful.

Benefits

Nitric oxide production declines naturally with age — and rebuilding it is not about a one-time boost. It’s about creating a consistent daily routine that supports circulation, oxygen delivery, cellular energy, oral microbiome health, and skin renewal over time.

The most noticeable and lasting results come from daily use.

Just like exercise, nutrition, and sleep, nitric oxide support compounds with consistency:

Better circulation supports long-term cardiovascular wellness
Improved oxygen delivery helps sustain energy and endurance
A healthy oral microbiome strengthens natural nitric oxide production
Daily skin activation helps improve tone, texture, and radiance over time

Small daily habits create meaningful long-term transformation.

A Single Lozenge, Hour by Hour

Nitric oxide goes to work the moment it’s released. Here’s the documented timeline of physiological effects following one N1o1 Nitric Oxide Lozenge — a window into why the whole system compounds over time.

12 seconds — Carotid arteries begin to dilate, increasing blood flow to the brain.
1 minute — Blood vessels dilate, enhancing circulation throughout the body.
10 minutes — Carotid arteries dilate ~13%, raising blood flow to the brain and body by ~34%.
20 minutes — For elevated readings (130–139/80–89 mmHg), systolic and diastolic pressure drop by 5–6 mmHg.
4 hours — Endothelial function improves 15–25%, boosting natural nitric oxide production.
1 month — In pre-hypertension and hypertension, blood pressure decreases ~12 mmHg systolic / 6 mmHg diastolic; triglycerides drop ~27%.
6 months — Existing arterial plaque stabilizes and begins to regress (~11%); endothelial function normalizes.
12 months — Arterial health improves, telomeres stabilize, and cognitive gains appear in verbal memory and problem-solving.

Figures reflect Dr. Bryan’s published research and clinical literature; individual results vary.

Timeline of Benefits

Immediate Support — Within Minutes

Increased blood flow begins almost immediately
Enhanced oxygen delivery supports mental clarity and circulation
Many users notice improved energy, warmth, focus, or workout readiness

Days 1–7

More sustained natural energy without stimulants
Fresher breath and healthier-feeling mouth
Improved hydration and exercise recovery
Skin may begin appearing brighter and more refreshed

Weeks 2–4

Better endurance and workout efficiency
More consistent energy throughout the day
Improved circulation and cardiovascular support
Smoother-looking skin texture and healthy glow

Months 2–6

Long-term support for vascular health and endothelial function
Improved recovery and performance capacity
Healthier oral microbiome and gum support
Firmer, more radiant, youthful-looking skin

6–12 Months

Compounding benefits from sustained nitric oxide support
Healthy aging support from improved circulation and cellular oxygenation
Continued support for cognitive function, vitality, and overall wellness
A stronger foundation for long-term performance and longevity

How to Use

How To Use: Your Daily Ritual

Morning
Brush with Breath of Life Toothpaste — spit, don’t rinse, so the hydroxyapatite keeps working. Mix one scoop of N.O. Beetz into 2-3 oz of water and consume immediately as a shot for clean, sustained energy.

Midday
Place one N1o1 Nitric Oxide Lozenge on your tongue and let it dissolve fully (about 5–6 minutes), then swallow the remaining saliva. Hydrate before use.

Evening
Brush again with Breath of Life, take a second lozenge ~12 hours after the first, and apply the Nitric Oxide Age-Defiance Serum to clean skin — some users may experience the signature pink flush due to increased microcirculation and blood flow as it activates.

Pro Tip

If you have acidic saliva, swish with baking soda and water before the lozenge.

Why the System Works Better Together

The N1o1 Total-Body Nitric Oxide System supports nitric oxide production from multiple pathways simultaneously:

N1o1 Lozenges → fast nitric oxide activation and circulation support
N.O. Beetz + PEAK ATP® → sustained energy, endurance, and cellular performance
CardioSmile Toothpaste → supports the oral microbiome essential for nitric oxide production
Nitric Oxide Age-Defiance Serum → activates nitric oxide directly on the skin for visible rejuvenation

Together, they create a complete daily nitric oxide ritual designed to support energy, performance, cardiovascular wellness, healthy aging, and longevity.

Watch & Learn

Watch and learn how N1o1 Nitric Oxide Body & Mind Essentials work together to support nitric oxide production, circulation, energy, oral health, skin health, and whole-body wellness.

Susan Shaffer
President & Co-Founder of N1o1 Nitric Oxide

Dr. Nathan Bryan
Founder & CEO of N1o1 Nitric Oxide

Ingredients

Science Backed Ingredients

Breath of Life Toothpaste

Hydroxyapatite: Rebuilds and remineralizes enamel — a natural, fluoride-free alternative.
Potassium Nitrate: Soothes nerve endings to relieve tooth sensitivity.
Zinc Citrate: Controls plaque and helps prevent gingivitis.
Xylitol & Erythritol: Reduce harmful bacteria while sparing the beneficial microbiome.
Essential Oil Blend: Peppermint, spearmint, wintergreen, tea tree, eucalyptus, and thyme for fresh breath and natural antimicrobial benefit.
Fluoride-free • No harsh antiseptics • No SLS sulfates

N1o1 Nitric Oxide Lozenges

Vitamin C (Magnesium Ascorbate): Helps support nitric oxide activation and antioxidant protection.
N1o1™ Proprietary Blend: Activates nitric oxide as the lozenge dissolves for circulation and cardiovascular support.
Sodium Nitrite: Works with saliva and natural physiology to generate nitric oxide.
Gluten-Free, Vegan, Non-GMO Formula: Clean daily support designed for a variety of lifestyles and wellness routines.
Gluten-Free, Vegan, Non-GMO.

N.O. Beetz

Vitamins C & D: Provides antioxidant support and immune health benefits.
Electrolyte Blend: Magnesium, Zinc, Manganese, Sodium, and Potassium help support hydration and cellular function.
NO2U™ Proprietary Blend: Supports nitric oxide production for circulation, oxygen delivery, and endurance.
Fermented Beetroot Powder: Pre-converted beet support designed for nitric oxide activation without high oxalate content.
D-Ribose: Helps support natural cellular energy production.
Patented PEAK ATP®: Clinically studied to support strength, power output, recovery, and athletic performance.
Oxalate-free • Electrolytes • Keto-Friendly • Gluten-free • Vegan • Non-GMO

Nitric Oxide Activating Age-Defiance Serum

Ascorbic Acid (Vitamin C): Supports antioxidant protection and collagen health for brighter-looking skin.
Sodium Nitrite: Helps activate nitric oxide to support skin renewal and healthy-looking radiance.
d-Tocopheryl Acetate (Vitamin E): Provides antioxidant defense to help protect and nourish skin.
Antioxidant-rich • Nitric oxide activated • Daily age-defense support

FAQs

What makes Breath of Life Toothpaste different from other toothpastes?

Breath of Life is a first-of-its-kind toothpaste designed to actively support your body’s nitric oxide ecosystem — not just clean teeth. It’s the world’s first toothpaste built around nitric oxide production and a healthy oral microbiome, linking oral care to whole-body circulation. It remineralizes with hydroxyapatite instead of fluoride, nurtures beneficial bacteria rather than wiping them out with harsh antiseptics, relieves sensitivity with potassium nitrate, and freshens breath with clean essential oils — all developed by leading nitric oxide researcher Dr. Nathan S. Bryan.

How do the four products work together?

Each targets nitric oxide from a different angle: the lozenge for fast systemic support, N.O. Beetz for sustained energy and endurance, Breath of Life to prime the oral microbiome, and the serum for visible skin renewal. Used together, they create a synergistic daily routine for circulation, energy, oral health, and age-defying results.

When will I notice results?

Many people feel fresher breath and a quick energy lift right away. Skin glow, smoother texture, and steadier energy typically build over days to weeks of consistent use, with cardiovascular and oral-health benefits compounding over months.

Is the collection safe for daily use?

Yes. All four products use clean, non-toxic, clinically informed ingredients designed for daily use. The lozenges are formulated for adults; check with a healthcare provider regarding minors.

Can I use Breath of Life if I have sensitive teeth?

Yes. It contains potassium nitrate to soothe nerve endings and hydroxyapatite to strengthen the enamel barrier, making the switch comfortable.

Dr. Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

Studies

[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
Annals of Plastic & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF

[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF

[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF

[5] A Novel Combination Therapy in Aesthetic and Reconstructive Surgery: Sea Salt Exfoliation, Cavitating Ultrasound, and High Intensity Multiwavelength LED Treatment: (SaltFacial)
Sciforschen Journal of Clinical and Cosmetic Dermatology
Greg Chernoff, BSc, MD, FRCSC*
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[6] Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
PubMed
Sandesh C S Nagamani, Philippe M Campeau, Oleg A Shchelochkov, Muralidhar H Premkumar, Kilian Guse, Nicola Brunetti-Pierri, Yuqing Chen, Qin Sun, Yaoping Tang, Donna Palmer, Anilkumar K Reddy, Li Li, Timothy C Slesnick, Daniel I Feig, Susan Caudle, David Harrison, Leonardo Salviati, Juan C Marini, Nathan S Bryan, Ayelet Erez, Brendan Lee
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Download the PDF

[7] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF

[8] Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Download the PDF

[9] Nitric oxide enhancement strategies
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Download the PDF

[10] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile

Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

Download the PDF

9 reviews for N1o1 Nitric Oxide Body & Mind Essentials

Rated 5 out of 5

Melissa P. – 06/16/2026

Since using the serum I’ve noticed smoother texture and a healthier glow. The toothpaste tastes great and leaves my whole mouth feeling fresh all day, and the supplements are amazing. Definitely recommend for a total-body N.O. boost.
Rated 5 out of 5

Beth – 06/16/2026

This bundle has the necessities for feeling and looking my best, daily. I love starting my day fresh with the toothpaste, and the N.O. Beetz are my go-to afternoon pick-me-up — they’ve replaced my old energy-drink habit.
Rated 5 out of 5

Sarah King – 06/16/2026

I needed something for fatigue and brain fog. Since adding the lozenge and N.O. Beetz, I feel like a new person, and the serum really improved my skin tone and texture. I feel more confident than ever.
Rated 5 out of 5

Chloe S. – 06/16/2026

I’ve tried so many serums, but this is the first that gave my skin a genuine, visible glow. I keep N.O. Beetz in my gym bag and the lozenges in my desk drawer for a quick boost before meetings — perfect for a busy schedule.
Rated 5 out of 5

Tasha R – 06/16/2026

Found Dr. Bryan through a podcast and ended up ordering this kit the same night — no regrets. The supplements have become part of my daily routine in a way nothing else has before, my skin looks healthier, and the toothpaste leaves my mouth feeling fresh all day. It all just works well together. Would recommend to literally everyone.
Rated 5 out of 5

Nick B. – 06/16/2026

I recommend this bundle to all of my friends and family after seeing Dr. Bryan talk about them on youtube. The toothpaste leaves a clean, refreshed feeling, and the NO beetz give a boost to my overall health and energy. If you’re looking for a convenient all-in-one set, this one is hard to beat.
Rated 5 out of 5

Sam H. – 06/16/2026

I watched Dr. Bryan speak about his nitric oxide products on Daystar and immediately ordered this bundle. The lozenge and serum have made my daily routine simpler. I appreciate that the toothpaste seems gentle yet effective, and I have the peace of mind that I am not putting dangerous chemicals in my body while taking care of my teeth. These products are a well-rounded wellness pack that works for someone like me who wants to cover a lot of bases without overthinking it.
Rated 5 out of 5

Michelle G – 06/16/2026

This mix of nitric-oxide lozenges, N.O Beetz ,Cardio Smile , and serum feels clean, easy to use, and works nicely together. I notice my daily vitality has improved and a my skin looks healthy . It’s a great choice if you a want simple way to feel and look your best as you go through your day.
Rated 5 out of 5

Emily S. – 06/16/2026

I bought this hoping for a little more vitality, and it delivered more than I expected. I not only have more physical energy, but I just feel a greater sense of overall wellness from head to toe. It’s a subtle but powerful change that has made a huge impact on my daily life.

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N1o1 Nitric Oxide Body & Mind Essentials

Elevate your wellness. Reclaim your vitality. Discover the power of nitric oxide.

Transform Your Health at a Cellular Level

What's Included?