Revitalize and Renew Your Skin
Healthy nitric oxide levels are crucial for optimal microcirculation and a radiant complexion. As we age, natural nitric oxide production declines, affecting skin tone, texture, and luminosity.
N1o1’s Nitric Oxide Age-Defiance Face Cream helps potentiate the nitric oxide production when used in combination with N1o1 nitric oxide activating serum. This unique process supports improved microcirculation for a brighter, smoother, and firmer-looking complexion. By harnessing Nobel Prize-winning nitric oxide science in a premium, clean formula, our cream addresses visible aging at its source. The result is visibly revitalized skin with a healthy, youthful glow.
What makes the Nitric Oxide Age-Defiance Face Cream unique?
Most face creams only work on the skin’s surface. N1o1 goes further, using the revitalizing benefits of nitric oxide to visibly rejuvenate your skin. Backed by Nobel Prize-winning science, our formula works at the cellular level to transform your skin from within. Unleash your skin’s youthful potential with our advanced Age Defiance Face Cream, expertly formulated with three powerful anti-aging ingredients designed to specifically target and transform problem skin.
- Nitric Oxide: The fundamental key to radiant, beautiful skin.
- Complex Peptide Formula: Essential building blocks that rejuvenate and visibly restore your complexion.
- Epidermal Growth Factor (EGF): Actively boosts natural collagen and elastin production for enhanced firmness and resilience.
Experience the visible transformation as our advanced formula revitalizes your skin’s youthful appearance from within.
- Reduce the appearance of wrinkles and dark spots for a rejuvenated look.
- Improve skin texture and tone, creating a smoother, more even complexion.
- Deliver deep hydration and essential protection to energize your skin.
- Stimulate collagen production and natural anti-aging processes.
- Activate the skin’s water management system for long-lasting moisture.
- Revitalize elasticity for a firmer, lifted appearance.
Strengthen the skin barrier, promoting healthier, more resilient skin cells.
Elizabeth Manning –
I’m a 33 year old mother from Colorado where the climate is constantly dry. When I say I’ve tried thousands of moisturizers & face creams, I’m being literal. This one is HANDS DOWN the best one I’ve found. It’s rich, absorbs quickly and the amount that you get is crazy. See pic(s) for reference. This will last me a long time because you only need a pea size for your entire face. I’ve already noticed my skin tone evening, lines softening and dark spots fading after only a few weeks. After week one, I started exploring other products from this line which haven’t disappointed either. Highly recommend pairing this with the Breath of Life serum. This line has changed my entire morning and night regime & I’m blown away by how effective it is. I’m not being paid for this, I’m just really, really happy with the results so far.
If you’re waiting for a sign, this is it: Buy it.
Bradley J. –
I’ve used a few moisturizers now and then on my face but generally I’ve used nothing my entire life. However, the wrinkles around my eyes got my attention. After looking at countless products I was intrigued by the ingredients in N1O1 Nitric Oxide Anti Aging Face Cream, particularly Nitric Oxide. I did a lot of reading and listened to a number of YouTube talks, lectures and interviews and finally decided to try this product. I put it on morning and night. I’m about 80% through my first jar and I have to admit it’s having an effect. Wrinkles are diminishing, lines I guess I’d describe as less deep and over all my skin is smoother – it’s noticeable. I’m also applying it to my neck. The skin just seems a little tighter. I plan to get a second jar and would recommend it.
Tina L. –
This is my second jar the first one was anti aging cream for my eye area and I like it so much that it improves my puffiness and age spots so I decided to try the face cream and so happy by this amazing product even though I have only try it for 10 days since I live in Taipei so it took a long journey through airport and post office to arrive to my hand (through relative who travelled to Taiwan often ) and already so impressed by my skin softness and feeling suppleness , try it you will never regret ! look at how much trouble for me to get it , it should be a prove by itself !
AuthorMom –
I just finished using my first jar of this Nitric Oxide face cream and I have ordered another, even though it is a little pricey. This is seriously amazing. I had two small skin tags under my eyes and they are both gone. In addition, the furrow between my eyes seems much better than in the past. I really like the way this feels as well. I’ve only been using it at night, so I can’t even imagine if I used it twice a day as directed!
Antoinette Simmons –
Has amazing action on some long standing dried non-healing skin lesions. Also pale dry, corpse-like complexion looks alive again. Hoping with long-term use I’ll see more uniformity in color and tone. Moisturizes well but a follow up with another moisturizing product enhances it. Scent is somewhat reminiscent of when parched earth is damped by light rainfall, so not your typical fruitiness of common moisturizers.
Monica L. (verified owner) –
As someone with perpetually dry, flaky skin, I was amazed at how deeply hydrating the Age-Defiance Face Cream is. My skin feels incredibly soft and nourished all day, and the texture has improved so much that my makeup applies more smoothly. It’s like my skin drank a glass of water every morning and night—an absolute game-changer!
Grace N. (verified owner) –
I’ve been searching for a face cream that truly addresses fine lines and wrinkles, and the Age-Defiance Face Cream has exceeded my expectations. The texture is so luxurious—it feels like a treat every time I put it on. Within just a few weeks, I noticed my skin tone looked more even, and the fine lines around my eyes and mouth started to soften. It’s given me a glow I haven’t seen in years, and I finally feel confident going makeup-free. This cream is worth every penny!
Natalie (verified owner) –
I’m absolutely in love with the Age-Defiance Face Cream! After just a few weeks of use, my skin tone looks brighter and more even, and I’ve even received compliments on my radiant glow. The cream feels incredibly lightweight—like a second skin—but it still delivers powerful hydration. What I love most is how quickly it absorbs, leaving no residue, so I can layer it under makeup seamlessly. This has become my secret weapon for glowing, healthy-looking skin!
Sharon (verified owner) –
I can’t believe the difference this face cream has made in my skin! The peptides in the formula work wonders—my cheeks feel noticeably firmer, and there’s a subtle lift around my jawline that wasn’t there before. My skin looks and feels so much more youthful and elastic. It’s like my face got its bounce back! I’m thrilled with the results and can’t imagine my routine without it.
Michael Tegan (verified owner) –
I’ll be honest—I never thought I’d be the guy writing about face cream, but here we are. At 41, I started noticing some deeper lines around my eyes and my skin felt rougher, especially after spending years in the sun. My wife suggested I try something besides basic aftershave, so I picked up the Age-Defiance Face Cream.
The texture is perfect for guys—not heavy or greasy, just smooth and absorbs quickly. I use it morning and night, and within about three weeks, the difference was obvious. My skin feels softer and looks smoother, and those crow’s feet that were really bugging me have definitely softened. Even my forehead lines look less pronounced.
What surprised me most was how natural it felt to use. No complicated routine, no weird smell—just a straightforward product that does what it says. My coworkers have even commented that I look more rested lately. If you’re a guy on the fence about trying something like this, don’t overthink it. This cream works, and your skin will thank you for it.
Kathy (verified owner) –
I like the light-weight texture. Made with lots of good ingredients. it goes on smoothly and absorbs well.
michelle sun (verified owner) –
Next to the lozenges, this is my second favorite product from Dr Nathan. I feel like I can really see a difference in my skin when I stop using it
Debbie Hang (verified owner) –
I’ve used a moisturizing face cream as part of my beauty regimen for years….but this Age Defiant Face Cream leaves my skin softer than anything I’ve ever tried! It’s light but effective. Not greasy at all.