Age-Defiance Gel Cleanser

(15 customer reviews)

Start and finish your skincare routine with a truly clean feel. This refreshing gel cleanser removes impurities, excess oil, sunscreen, and makeup. It also supports healthy microcirculation for a smoother, brighter, and more even complexion. With AHAs, Glycolic Acid, fruit enzymes and antioxidants, it preps your skin to better absorb subsequent treatments—so every step that follows works harder. Our gentle formula is made with clean ingredients and is phthalate-free and paraben-free.

Key Benefits May Support:

  • Gentle daily cleanse: Removes dirt, oil, and impurities without leaving skin tight or dry.
  • Brightens and evens tone: Unveils a fresh, radiant complexion with every wash.
  • Smooths and refines: Helps reduce the look of fine lines while improving texture and the appearance of pores.
  • Energizes skin on contact: Boosts microcirculation for a healthy, refreshed glow.
  • Primes for performance: Optimizes skin for enhanced absorption of serums and moisturizers.

$39.98 or Original price was: $39.98.Current price is: $31.98. / month

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What makes the Age-Defiance Gel Cleanser different?

Most cleansers aim for a surface clean. Our Age-Defiance Gel Cleanser goes further, infusing powerful skin science into your first routine step. This age-defying blend of fruit, flower, and plant extracts gently cleanses. Alpha-Hydroxy Acid (AHA) from passionflower, lemon, grape, and pineapple extracts (Glycolic, Lactic, Citric, Malic, Tartaric acids) encourages cell turnover and oxygenates skin cells. Antioxidants like Vitamin C and Green Tea brighten and protect, while Aloe Vera, Algae Extract, and Kola Nut Extract soothe. This gel cleanser purifies and invigorates, leaving skin soft, smooth, and receptive—never stripped. The result: clearer, brighter, and more refined skin.
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Results You Can See:

  • Immediately: Skin feels fresh, balanced, and comfortable—no residue or tightness
  • After 1 week: Visible improvement in clarity, smoothness, and radiance
  • With continued use: A more even tone and refined look of pores for a youthful-looking glow

How to Use for Best Results:

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What to expect

A cushiony gel that lathers lightly, rinses clean, and leaves skin soft. With consistent daily use, most users report fresher tone, smoother texture, and a healthy-looking glow within the first few weeks.

Boost your skin health from within with N1o1 Nitric Oxide Lozenges. These easy to dissolve lozenges enhance microcirculation, improve oxygen and nutrient delivery, and strengthen your skin’s barrier.

Additional information

Weight .4 oz
Dimensions 2 × 2 × 6 in

Why AHA & Fruit Enzymes Matter

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Why AHA & Fruit Enzymes Matter

This formula is enriched with AHA (alpha hydroxy acids), including glycolic acid, and natural fruit enzymes that work together to deliver gentle, effective exfoliation every time you cleanse. Our thoughtfully balanced blend helps loosen and lift away dull surface cells, revealing smoother, softer, and more radiant skin beneath. Unlike harsh scrubs, AHAs and fruit enzymes encourage cell turnover without irritation, improving texture and clarity. With regular use, you’ll notice a brighter, fresher complexion and a visibly refined appearance—while laying the groundwork for the rest of your skincare routine to work even better.

Ingredients

Key Ingredients

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Multi-AHA Complex (Glycolic, Lactic, Citric, Tartaric, Malic Acids):

Gently exfoliates to smooth texture, refine the look of pores, and brighten dullness for a fresh, even-looking tone.

N1O1 Nitric Oxide Age-Defiance Face Cream

Fruit Enzymes & Extracts (Pineapple, Passionfruit, Grape):

Enzyme-assisted exfoliation helps lift surface buildup while antioxidants support a clearer, more radiant complexion.

N1O1 Age-Defiance Gel Cleanser

Hydrating Humectants (Glycerin, Aloe Juice):

Draw in and retain moisture for a comfortable, non-stripping cleanse.

N1O1 botanical antioxidants soothers nitric oxide

Soothing Botanicals (Green Tea, Algae, Honeysuckle):

Help calm and condition skin for a soft, balanced feel after rinsing.

essential vitamins and nutrients

Vitamin C (Ascorbic Acid):

Antioxidant support to defend against environmental stressors and promote post-cleanse luminosity.

skin health and rejuvenation

Skin-Conditioning Polymers:

Create a soft, cushiony lather and leave skin feeling smooth

hydration and wellness for health and wellness

Water:

Provides a clean base for optimal delivery and easy rinse-off

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Full Ingredient List:

Water, Ammonium Lauryl Sulfate, Glycerin, Hydroxyethylcellulose, Potassium Oleate, Potassium Cocoate, Glycolic Acid, Lactic Acid, Citric Acid, Tartaric Acid, Malic Acid, Passiflora Edulis Fruit Extract, Ananas Sativus (Pineapple) Fruit Extract, Vitis Vinifera (Grape) Fruit Extract, Aloe Barbadensis Leaf Juice, Algae Extract, Ascorbic Acid, Camellia Oleifera Leaf Extract, Lonicera Caprifolium (Honeysuckle) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Propanediol, Cola Acuminata Seed Extract, Polysorbate 20, Fragrance, Alcohol Denat., Potassium Citrate, Tetrasodium EDTA

Watch & Learn

Glow confidently and embrace timeless skin with the N1o1 Age-Defiance Gel Cleanser—your first step to a radiant, youthful complexion. Watch this video to learn how to get the best results:

Susan Shaffer,
President & Co-Founder of N1o1 Nitric Oxide

Dr. Bryan

Dr. Nathan Bryan Dr. Nathan Bryan nitric oxide researcher

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

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A Pioneer in Nitric Oxide Science

With over 25 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

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Clinically Backed & Scientifically Proven

His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the Age-Defiance Gel Cleanser you’re about to experience.

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On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

FAQs

What makes this cleanser different from others?
The Age-Defiance Gel Cleanser brings 20 years of science–inspired benefits to the first step of your skincare routine—cleansing effectively while supporting microcirculation for a brighter, smoother look and superior product absorption.
Yes. It’s formulated to cleanse without stripping, leaving skin comfortable and balanced—ideal for all skin types, including sensitive, oily, dry, and combination.
Yes. Use the Gel Cleanser first, pat dry, then apply the N1o1 Nitric Oxide Activating Serum. This increases the absorption of other skincare products. When using the full Nitric Oxide Age-Defiance Skincare System, follow with the Age-Defiance moisturizer and eye cream, both morning and night.
Pro tip: For a deeper exfoliation, let the cleanser sit a little longer than usual before rinsing off.
Immediately after washing, skin feels fresh and looks more radiant. With daily use, most users see visible improvements in clarity, texture, and tone within 2–4 weeks.
Yes. N1o1 products are vegan, cruelty-free, gluten-free, and non-GMO.

Storage and guarantee
Store in a cool, dry place and use by the date on the package. Backed by our 60-day money-back guarantee.

Clinical note
For optimal cosmetic results, follow daily cleansing with the clinically proven N1o1 Nitric Oxide Activating Age-Defiance Serum. Doctor-formulated by Dr. Nathan S. Bryan, clinical studies show this serum improves skin tone, texture, and reduces fine lines.

Ready to elevate your first step? Add the N1o1 Age-Defiance Gel Cleanser to your routine and unlock a brighter, smoother, more youthful-looking complexion.

Studies

[1] Dual Effects of Alpha-Hydroxy Acids on the Skin
PubMed
Sheau-Chung Tang, Jen-Hung Yang
Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien 97004, Taiwan
Department of Dermatology, Buddhist Tzu Chi General Hospital, Hualien 97004, Taiwan
Download the PDF

[2] Topical AHA in Dermatology: Formulations, Mechanisms of Action, Efficacy, and Future Perspectives
MDPI
Kanwarpreet Karwal, Ilya Mukovozov
Faculty of Medicine, Schulich School of Medicine and Dentistry, London, ON N6A 5C1, Canada
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC V5Z 4E8, Canada
Download the PDF

[3] Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF‐alpha in human skin explants
PubMed
Mridvika Narda, Carles Trullas, Anthony Brown, Jaime Piquero‐Casals, Corinne Granger, Gabriella Fabbrocini
Innovation and Development, ISDIN, Barcelona, Spain
External consultant to ISDIN, Barcelona, Spain
Dermik Clinica Dermatologica Multidisciplinar, Barcelona, Spain
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Frederico II, Naples, Italy
Download the PDF

15 reviews for Age-Defiance Gel Cleanser

  1. Dr. Katerina

    So I used that cleanser. Rinsed. And holy… It looked like I had a facial, and a treatment, and who knows what else? My skin was tight, smooth, and bright. I was like whoa. Then I looked at the ingredients. And I was like. Smart. So smart.

  2. mrkashif201

    Nice Product

  3. Cat C.

    I absolutely love the age-defiance gel cleanser! It gives such a gentle, refreshing cleanse, removing all traces of dirt and makeup without drying out my skin. After using it, my skin feels soft, smooth, and incredibly hydrated. It’s become an essential part of my skincare routine, and I can’t imagine starting or ending my day without it.

  4. Veronica

    This Pneuma Age-Defiance Gel Cleanser is pretty decent! I never tried a cleanser that Oxygenates, Exfoliates, Brightens, Protects and Soothes Skin, so this is a first for me! I have fairly sensitive skin and have had no adverse reactions. A little goes a long way! One little pump was all it took to cleanse my face. I wear minimal makeup (tinted spf , primer and some powder) and it washed all my makeup off while still cleansing my skin really well! It has some great ingredients such as: Antioxidants, AHA, Glycolic Acid, Aloe, Green Tea, Fruit Extracts, and Natural Botanicals.

  5. Elle

    This is a great cleanser. It costs a little more than I’m accustomed to spending; however, it’s definitely effective in removing all of my makeup with just a small dollop of product. The scent is lovely, just clean smelling, and this leaves no residue on my face so I feel like I can skip the toner once in a while. It’s a very nice cleanser!

  6. Rita

    I love mine . Use it along with the serum 😍

  7. Shelly

    My skin has never felt this refreshed after cleansing! The Age-Defiance Gel Cleanser removes every trace of makeup and dirt without stripping my skin, leaving it soft, smooth, and visibly brighter. The natural ingredients like green tea and aloe give it a lovely, gentle touch, and the light foam texture feels invigorating. It’s now a staple in my routine—I can’t start my day without it!

  8. Jess K.

    As someone who struggles with dull, uneven skin, I was amazed at how quickly the Age-Defiance Gel Cleanser made a difference. The AHAs in the formula gently exfoliate without irritation, leaving my skin super smooth and radiant after every use. It’s like a mini facial in a bottle! My complexion feels renewed and looks brighter, making this cleanser a must-have in my skincare routine. I can’t recommend it enough!

  9. Laura T.

    I have sensitive skin that reacts to almost everything, but the Age-Defiance Gel Cleanser has been a dream come true. The soothing combo of aloe and green tea calms any redness while providing a deep, refreshing clean. After every use, my skin feels balanced, comfortable, and noticeably healthier. Can’t live without it!

  10. Michelle D.

    Removing makeup at the end of a long day used to feel like such a chore, but the Age-Defiance Gel Cleanser has completely changed my routine. Its lightweight formula glides on effortlessly, dissolving every bit of foundation, mascara, and dirt in one go. Best of all, it leaves my skin feeling fresh and clean without any greasy residue. My face feels light and breathable afterward, and I love how simple and effective it is. I’ll never go back to my old cleansers!

  11. Lydia

    What I love most about this cleanser is how it leaves my skin feeling fresh, clean, and never oily. My face feels light, refreshed, and revitalized. It’s a perfect blend of simplicity and effectiveness.

  12. Randy

    As a guy who’s always kept skincare simple, I wasn’t expecting much from the Age-Defiance Gel Cleanser—but it’s been a pleasant surprise. It gives my skin a deep, thorough cleanse without that tight, over-scrubbed feeling I get from most face washes. The natural ingredients like aloe and green tea make it gentle enough for daily use, and it actually leaves my skin feeling refreshed and smooth. It’s become part of my morning routine, and I’ve noticed my skin looks clearer and less dull. Simple, effective, and worth the upgrade from my old drugstore cleanser.

  13. David P.

    I work in construction and spend most of my days outdoors, so my skin takes a beating from dust, sweat, and sun. Regular soap just wasn’t cutting it—my face always looked rough and felt grimy even after washing. The Age-Defiance Gel Cleanser changed everything. The exfoliating action gets all the grime out of my pores without being harsh, and I was shocked at how much brighter my skin looked after just a week.
    What really impressed me was how it handles the daily buildup from my job. After a long day on-site, this cleanser actually makes my skin feel clean and fresh again. My girlfriend even commented that my complexion looks healthier and more even. For a guy who never paid much attention to skincare, this stuff delivers real results. It’s become essential for my post-work routine—wouldn’t go without it now.

  14. Patrick

    As a man who never put much thought into skin care beyond using bar soap, I didn’t think you’d would do much for me. But wow. What a difference. When I look into the mirror, I feel like I’m looking back at my younger self.

  15. Ari Kim

    This cleanser is really refreshing! But I find that if I use this twice a day on my face, it’s a little drying.. so I started to use it only at night. I’ve heard from a lot of dermatologists that you don’t actually need to wash your face twice because it strips away the natural oils. Now that I’m only using the cleanser once a day, my skin is still fresh in the morning. This small change in routine has made a difference without drying out my skin.

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