What is nitric oxide and why is it important?

Nitric oxide (NO) is a signaling molecule produced naturally in your body that plays a critical role in cardiovascular health, blood pressure regulation, immune function, and cellular communication. Production declines with age, making supplementation beneficial.

How do N1O1 nitric oxide lozenges work?

N1O1 lozenges dissolve on the tongue and deliver a patented nitric oxide formula directly through the oral mucosa, bypassing the digestive system for faster absorption. They help restore nitric oxide levels that naturally decline with age.

Who is Dr. Nathan S. Bryan?

Dr. Nathan S. Bryan is a world-renowned nitric oxide biochemist and the founder of N1O1. He has over 20 years of research in nitric oxide science, authored multiple books, and holds numerous patents in nitric oxide technology.

What are the benefits of nitric oxide supplements?

Nitric oxide supplements may support healthy blood pressure, improved circulation, cardiovascular health, enhanced athletic performance, immune function, cognitive health, and anti-aging at the cellular level.

N.O. Beetz is N1O1's beet-based nitric oxide supplement that harnesses the natural nitrate content of beets to boost nitric oxide production. Available individually or in a buy-3-get-1-free bundle.

Does N1O1 offer skincare products?

Yes, N1O1 offers a complete Age-Defiance Skincare System including an activating serum, face cream, eye cream, and gel cleanser — all formulated with nitric oxide technology to promote skin health and anti-aging.

How should I take N1O1 lozenges?

Place one lozenge on your tongue and allow it to fully dissolve. Do not chew or swallow whole. For best results, use daily as directed on the product label.

Are N1O1 products backed by science?

Yes, N1O1 products are developed by Dr. Nathan S. Bryan based on decades of peer-reviewed nitric oxide research. The formulations are protected by multiple patents and supported by clinical data.

What is CardioSmile toothpaste?

CardioSmile is N1O1's nitric oxide-boosting toothpaste that supports oral and cardiovascular health. Unlike conventional toothpastes that contain antiseptics that kill beneficial oral bacteria needed for nitric oxide production, CardioSmile promotes a healthy oral microbiome.

Do you offer bundle deals?

Yes, N1O1 offers several bundles including the Nitric Oxide Booster Bundle, Anti-Aging Bundle, Dyno Duo, Couples Performance Bundle, Body & Mind Essentials, and buy-3-get-1-free deals on lozenges and N.O. Beetz.

Is N1O1 suitable for athletes?

Yes, nitric oxide plays a key role in blood flow and oxygen delivery to muscles. Many athletes use N1O1 lozenges to support performance, recovery, and endurance.

What is the Nitric Oxide Oral Wellness Duo?

The Oral Wellness Duo combines N1O1 nitric oxide lozenges with CardioSmile toothpaste for comprehensive oral and cardiovascular support through nitric oxide restoration.

Do you ship internationally?

Shipping details and policies are available on the N1O1 website. Visit the Shipping and Returns Policy page for the most current information.

Can nitric oxide help with aging?

Research shows nitric oxide production declines with age, contributing to cardiovascular issues, reduced energy, and skin aging. Restoring NO levels through supplementation may help address these age-related changes.

Where can I learn more about nitric oxide?

N1O1 offers extensive educational resources including the Nitric Oxide Knowledge Base, Nitric Oxide Glossary, featured podcasts, press features, and Dr. Bryan's books 'The Secret of Nitric Oxide' and 'Nitric Oxide Nutrition'.

N1O1 Fresh and Bright Bundle | Cleanser + Eye Cream Set

Name: N1O1 Fresh and Bright Bundle | Cleanser + Eye Cream Set
Brand: Pneuma Nitric Oxide
SKU: FNB-1
Price: 89.96 USD
Availability: InStock

What's Inside

Step 1: Age-Defiance Gel Cleanser

A refreshing, science-driven gel cleanser that gently removes impurities while supporting microcirculation and prepping skin for maximum absorption.

Key Benefits:

Removes dirt, oil, sunscreen, and makeup without stripping.
Brightens and refines skin tone.
Gently exfoliates with AHAs & fruit enzymes.
Energizes skin for a fresh, healthy glow.
Optimizes performance of eye cream and treatments.

Step 2: Nitric Oxide Boosting Age-Defiance Eye Cream

A targeted eye treatment that works at the cellular level to improve microcirculation, hydration, and elasticity where skin is thinnest and aging shows first.

Key Benefits:

Potentiates nitric oxide production to support healthy, radiant skin.
Minimizes puffiness and under-eye circles, leaving you looking bright and refreshed.
Smooths the appearance of fine lines and wrinkles for a more youthful look.
Firms and improves skin texture and elasticity.
Provides deep hydration to the delicate skin around your eyes.

Why Nitric Oxide?

Why Nitric Oxide Matters for Your Eyes

Nitric oxide serves as a vital signaling molecule within the body, playing a crucial role in supporting microcirculation. By maintaining healthy blood flow at the surface, it helps to efficiently deliver essential oxygen and life-giving nutrients directly to your skin cells. However, as we age, our natural nitric oxide production begins to decline. This reduction means the delicate under-eye area can become more prone to a dull appearance, persistent puffiness, and other visible signs of aging.

To address these changes, the N1o1 Nitric Oxide Fresh & Bright Bundle has been specifically designed to support nitric oxide activity through topical application. By assisting the skin’s natural processes, this bundle helps the eye area look visibly brighter, smoother, and more refreshed. Start by cleansing the skin with the Age-Defiance Gel Cleanser, a blend of AHAs and glycolic acid from fruit enzymes to prep your skin. To enhance its effects, apply the Nitric Oxide Activating Age-Defiance Serum for optimal absorption. Then, apply the Nitric Oxide Boosting Eye Cream to target fine lines and dark circles, locking in essential moisture. With consistent daily use, you can better manage the effects of declining levels and maintain a more rejuvenated appearance.

What Makes the N1o1 Nitric Oxide Fresh & Bright Bundle Different?

Unlike traditional eye products that only address surface concerns, this bundle works synergistically to cleanse, activate, and replenish skin from the first step to the last.

Powered by Advanced Skin Science

Nitric Oxide–Activating Technology – Supports healthy microcirculation
Multi-Peptide Complex – Helps restore firmness and smooth wrinkles
Hyaluronic Acid & Sodium PCA – Deep hydration for plumper skin
Ceramide Complex – Strengthens the skin barrier
Botanical Antioxidants – Calm and protect delicate under-eye skin

Backed by decades of nitric oxide research and Nobel Prize-recognized science.

How To Use

Morning & Night Ritual

Cleanse:
Apply 2–3 pumps of Age-Defiance Gel Cleanser to damp skin. Massage gently over face and eye area for 30–60 seconds. Rinse and pat dry. * For a deeper exfoliation, let the cleanser sit a little longer than usual before rinsing off.
Treat:
Apply a small amount of Age-Defiance Eye Cream around the orbital bone. Gently pat with your ring finger until absorbed.

Storage:

Store in a cool, dry place. Use before the expiration date printed on the package.

What to Expect

Immediately

Skin feels clean, refreshed, and hydrated
Eyes appear brighter and more awake

Within 30 Days

Visible improvement in dark circles and puffiness
Smoother-looking fine lines
Firmer, more youthful-appearing under-eye skin

Results improve with consistent daily use.

Key Ingredients

Age-Defiance Gel Cleanser

Highlights

Multi-AHA Complex (Glycolic, Lactic, Citric, Malic, Tartaric Acids) – Gently exfoliates, smooths skin texture, and promotes cell renewal.
Fruit Enzymes (Pineapple, Passionfruit, Grape) – Naturally dissolves dead skin cells for a brighter, more radiant complexion.
Aloe Vera & Glycerin – Provides deep hydration and soothes the skin, leaving it soft and comfortable.
Vitamin C & Green Tea – Delivers brightening antioxidant support to protect against environmental stressors and even skin tone.
Green Tea, Cucumber, Dunaliella Salina – Antioxidant protection.

Nitric Oxide Boosting Age-Defiance Eye Cream

Highlights

Sodium Nitrite – Nitric oxide–activating component that improves circulation and reduces puffiness.
Palmitoyl Tripeptides & Tetrapeptides – Firms and smooths the skin to reduce the appearance of fine lines and wrinkles.
Ceramides (NP, NS, EOS, EOP, AP) – Provides barrier support to lock in moisture and protect the delicate under-eye area.
Sodium Hyaluronate & Tremella Mushroom – Delivers advanced hydration to plump the skin and restore its youthful bounce.

FAQs

What is the N1o1 Nitric Oxide Fresh & Bright Bundle?

A two-step routine that includes the Age-Defiance Gel Cleanser and Nitric Oxide Boosting Age-Defiance Eye Cream to help cleanse, hydrate, and visibly improve the appearance of dark circles, puffiness, fine lines, and dryness.

How does nitric oxide support the look of the under-eye area?

Nitric oxide is a signaling molecule associated with healthy microcirculation, which helps support delivery of oxygen and nutrients to skin—promoting a brighter, smoother, more refreshed appearance.

Who is this for?

Anyone concerned with puffiness, dark circles, fine lines, dehydration, or dullness—and anyone who wants a daily eye routine that supports a more youthful-looking under-eye area.

Is it safe for sensitive skin?

The bundle is formulated to be gentle for most skin types, including sensitive skin. If you have highly reactive skin, we recommend a patch test first, as the cleanser contains AHAs and fruit acids.

How do I use it for best results?

Use morning and night: cleanse, pat dry, then apply a small amount of eye cream around the orbital bone and gently pat until absorbed.

When will I see results?

Many users notice a refreshed look quickly (hydration + smoother appearance). With consistent use, most people see visible improvements in 30 days.

Can it help with puffiness and dark circles?

It’s formulated to help reduce the appearance of puffiness and dark circles by supporting microcirculation and hydration, plus skin-soothing ingredients that help the under-eye look calmer and brighter.

Will it help with wrinkles and fine lines?

Yes—peptides, hydration boosters, and barrier-supporting ingredients help visibly smooth the look of fine lines and improve the look of firmness over time.

Is it vegan and cruelty-free?

Yes, our products are vegan, cruelty-free, gluten-free, non-GMO.

What other products can I use with this bundle?

For the optimum results, use this collection alongside our N1o1 Nitric Oxide Age-Defiance Skincare System. Used together, they provide a comprehensive routine that targets visible aging to reveal a more radiant, youthful complexion over time.

Reveal Brighter Eyes

Reveal Brighter, More Youthful-Looking Eyes

Upgrade your routine with the N1o1 Nitric Oxide Fresh & Bright Bundle—two science-powered steps designed to cleanse, activate, and visibly transform the delicate under-eye area.

Dr. Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

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N1o1 Nitric Oxide Fresh & Bright Bundle

Cleanse. Activate. Revitalize.

Revitalize Your Appearance with the Power of Nitric Oxide

Nitric Oxide Boosting Age-Defiance Eye Cream

Revitalize Your Eyes with the Power of Nitric Oxide

Age-Defiance Gel Cleanser