Looking for a powerful way to rejuvenate your skin? The N1o1 Nitric Oxide Activating Anti-Aging Skincare System is scientifically designed to restore your skin’s natural nitric oxide levels, improving circulation, reducing fine lines, and promoting a youthful glow. Powered by groundbreaking Nobel Prize-winning science, this advanced skincare system works at the cellular level to enhance hydration, elasticity, and overall skin health.
Featuring:
Maximum of 1 bundle per order due to popular demand
Original price was: $299.92.$269.92Current price is: $269.92. — available on subscription
| Weight | 3.0 oz |
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Nitric oxide plays a vital role in promoting skin and overall health. This naturally occurring molecule helps improve blood flow, delivering essential nutrients and oxygen to the skin, which can enhance its radiance and elasticity. It also supports the body’s ability to reduce inflammation and combat oxidative stress, contributing to a healthier complexion and faster healing of damaged skin.
While we’re born with the ability to produce nitric oxide naturally, its levels decline significantly as we age. This decrease can impact blood flow, skin health, and overall vitality. Beyond skin health, nitric oxide is crucial for cardiovascular health, as it helps relax blood vessels, regulate blood pressure, and improve circulation. Its multifunctional benefits make nitric oxide an essential component in maintaining both skin vitality and overall well-being.
Created by Dr. Nathan S. Bryan, a leading expert in nitric oxide research, this innovative skincare system is backed by science and designed to optimize your skin’s natural processes.
Nitric oxide is vital for maintaining healthy skin circulation and hydration. This skincare system helps your skin produce nitric oxide effectively, promoting a brighter, smoother, and healthier complexion.
Visibly reduce wrinkles, improve skin elasticity, and diminish signs of aging while enhancing overall skin health.
Developed by Dr. Nathan S. Bryan, a world-renowned nitric oxide researcher, this system uses advanced biochemistry to deliver real, lasting results.
This system fits seamlessly into your daily skincare routine, delivering fast-acting results that you can feel and see.
Beyond visible improvements, the N1o1 Skincare System supports long-term skin health with continued use, leaving you with radiant, resilient skin that defies age.
Support your skin’s natural processes with the N1o1 Nitric Oxide Activating Anti-Aging Skincare System and discover the transformative benefits of nitric oxide for your skin.
The gel cleanser is designed to gently remove dirt, oil, and makeup without stripping the skin. It removes impurities and preps the skin for optimal absorption of active ingredients. With its advanced formula, it supports overall skin health and vitality.
Key benefits include:
The Nitric Oxide Activating Serum boosts nitric oxide levels to improve circulation, stimulate collagen production, and deliver essential nutrients to the skin. With 20% Vitamin C, it targets wrinkles and skin damage for a radiant, youthful complexion.
Key benefits include:
The Nitric Oxide Age-Defiance Eye Cream is formulated with peptides, hyaluronic acid, and other active ingredients to restore nitric oxide levels, improve hydration, and promote collagen production.
Key benefits include:
The Nitric Oxide Age-Defiance Face Cream penetrates deeply to restore skin health at a cellular level. Nitric oxide enhances circulation, peptides rejuvenate skin, and EGF stimulates collagen and elastin production, leaving your skin firm, radiant, and youthful.
Key benefits include:
Stimulation of collagen and elastin production for firmer, rejuvenated skin.
Nitric oxide enhances circulation, peptides restore and rejuvenate, and EGF boosts collagen and elastin, leaving your skin firm, healthy, and youthful.
Yes, the Age-Defiance Skincare System is designed to work with all skin types, providing hydration, nourishment, and anti-aging benefits.
Our N1o1 Nitric Oxide Activating Age-Defiance Serum is scientifically formulated and clinically proven in 5 peer-reviewed published studies to deliver results inspired by a Nobel Prize-winning discovery.
For best results, use the cleanser, serum, eye cream, and face cream daily as part of your skincare routine. Follow the instructions on each product for optimal usage.
MEET THE FOUNDER
Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.
With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 Nitric Oxide Age-Defiance Skincare System you’re about to experience.
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
Annals of Plastic & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF
[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF
[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF
[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF
[5] A Novel Combination Therapy in Aesthetic and Reconstructive Surgery: Sea Salt Exfoliation, Cavitating Ultrasound, and High Intensity Multiwavelength LED Treatment: (SaltFacial)
Sciforschen Journal of Clinical and Cosmetic Dermatology
Greg Chernoff, BSc, MD, FRCSC*
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF
AS SEEN IN
Mariann –
The Nitric Oxide Age-Defiance Skincare System is fantastic! My wrinkles have softened, and my skin looks radiant. The serum and moisturizer feel luxurious and absorb quickly. Highly recommend this for anyone looking to combat signs of aging!!
Carly S. –
This system is a game-changer. The gel cleanser leaves my face feeling clean but not dry, and the activating serum has really evened out my skin tone. I’ve also noticed my skin feels firmer. Highly recommend!
Alexis B. –
I wasn’t expecting such a quick lift, but wow—my skin feels tighter and looks noticeably smoother. I started using the Nitric Oxide Age-Defiance Serum morning and night, then followed with the Face Cream. Within two weeks, my cheeks felt so smooth and those tiny texture bumps on my forehead softened. My pores also look more refined.
What I love:
The serum sinks in fast with a gentle pink flush that fades in minutes.
The face cream locks everything in without heaviness, so makeup goes on like a dream.
I’m 47, a fitness coach who’s in front of clients all day, and I feel camera-ready without filters. This combo gave me the smooth, taut look I’ve been chasing for years.
— Jenna P. –
I was dealing with dull, congested skin that never looked truly clear, no matter what I tried. The Nitric Oxide Age-Defiance Skincare System changed that within weeks. The routine is straightforward—cleanser, serum, eye cream, face cream—and it takes me less than five minutes morning and night. My complexion looks clearer, pores appear more refined, and there’s a healthy glow that wasn’t there before. Even on no-makeup days, my skin looks bright and fresh. If you want visible clarity and a youthful radiance without a complicated routine, this system delivers.
Danielle M. –
As someone with melasma and uneven tone, I’ve tried a lot of systems that overpromise. This one actually delivered. The gel cleanser gives a fresh, clean feel without stripping—my skin looks brighter right after washing. The activating serum is the star: within 3 weeks, my cheeks and forehead looked more even, and my jawline feels noticeably firmer. Makeup sits better, and I’m confident going bare-faced more often. It’s simple, effective, and worth it.
Kelly R. –
I’d been frustrated with deepening crow’s feet and a rough, uneven texture that made makeup settle into lines. After a month with the Nitric Oxide Age-Defiance Skincare System, the change is obvious—my wrinkles look softer and my skin feels smoother to the touch. The serum and creams feel downright luxurious, glide on like silk, and absorb fast without any greasy residue. I love that I can layer them and get on with my day. This is the first routine that’s made my skin look and feel refined again. Absolutely thrilled with the results.
Victoria Davids –
I’m a huge fan of Dr. Bryan and his work. This skincare system is unlike anything else on the market. Five stars!!
Polly –
I love how this skincare system has replaced my previously mis-matched routine. Instead of buying random “trendy” products that I see on social media, this is now my go-to. It’s such a simple routine that I am happy to use daily!
Annie Lo –
This is truly next level science and skincare. Who would have thought the benefits of nitric oxide could be seamlessly infused into a skincare products? So so smart. The clinical studies speak for themselves.
Rozzy Liu –
The age-defiance skincare system is cutting-edge science meets skincare. After months of using the nitric oxide serum, I decided to try the entire system—and I couldn’t be happier with the results. The difference it makes in how my skin feels is remarkable.
Nickey Renzo –
I recently turned 43 and realized my current skincare products just weren’t doing the job anymore. I wanted something with cleaner, more effective ingredients and I’ve been hearing a lot about dr. bryan and his work. this skincare system is not complicated and worth the splurge