How To Use
EXFOLIATING GEL CLEANSER
NITRIC OXIDE ACTIVATING SERUM
NOTE: Within a few seconds your face may turn a slight pink due to an increase in Nitric Oxide. This may last up to 5 minutes.
EYE CREAM
FACE CREAM
- Apply to damp skin.
- Massage until a creamy, moisturizing foam develops.
- Rinse off thoroughly.
NITRIC OXIDE ACTIVATING SERUM
- Apply a single pump from each chamber to the palm of your hand, mix together and apply to the entire face and neck.
- Allow to fully absorb 1-2 minutes before applying other products.
- Continue as a daily routine, applying morning and night to a clean face.
NOTE: Within a few seconds your face may turn a slight pink due to an increase in Nitric Oxide. This may last up to 5 minutes.
EYE CREAM
- Using clean hands, apply cream to the eye area in the AM and PM.
- Dab gently around the eyes being careful not to get any product in the eyes.
- Allow cream to fully absorb 1-2 minutes.
FACE CREAM
- Use after cleaning and applying the Nitric Oxide activating serum.
- Apply with clean hands in the AM and PM.
- Allow to fully absorb 1-2 minutes.
Mariann –
The Nitric Oxide Age-Defiance Skincare System is fantastic! My wrinkles have softened, and my skin looks radiant. The serum and moisturizer feel luxurious and absorb quickly. Highly recommend this for anyone looking to combat signs of aging!!
Carly S. –
This system is a game-changer. The gel cleanser leaves my face feeling clean but not dry, and the activating serum has really evened out my skin tone. I’ve also noticed my skin feels firmer. Highly recommend!
Alexis B. –
I wasn’t expecting such a quick lift, but wow—my skin feels tighter and looks noticeably smoother. I started using the Nitric Oxide Age-Defiance Serum morning and night, then followed with the Face Cream. Within two weeks, my cheeks felt so smooth and those tiny texture bumps on my forehead softened. My pores also look more refined.
What I love:
The serum sinks in fast with a gentle pink flush that fades in minutes.
The face cream locks everything in without heaviness, so makeup goes on like a dream.
I’m 47, a fitness coach who’s in front of clients all day, and I feel camera-ready without filters. This combo gave me the smooth, taut look I’ve been chasing for years.
— Jenna P. –
I was dealing with dull, congested skin that never looked truly clear, no matter what I tried. The Nitric Oxide Age-Defiance Skincare System changed that within weeks. The routine is straightforward—cleanser, serum, eye cream, face cream—and it takes me less than five minutes morning and night. My complexion looks clearer, pores appear more refined, and there’s a healthy glow that wasn’t there before. Even on no-makeup days, my skin looks bright and fresh. If you want visible clarity and a youthful radiance without a complicated routine, this system delivers.
Danielle M. –
As someone with melasma and uneven tone, I’ve tried a lot of systems that overpromise. This one actually delivered. The gel cleanser gives a fresh, clean feel without stripping—my skin looks brighter right after washing. The activating serum is the star: within 3 weeks, my cheeks and forehead looked more even, and my jawline feels noticeably firmer. Makeup sits better, and I’m confident going bare-faced more often. It’s simple, effective, and worth it.
Kelly R. –
I’d been frustrated with deepening crow’s feet and a rough, uneven texture that made makeup settle into lines. After a month with the Nitric Oxide Age-Defiance Skincare System, the change is obvious—my wrinkles look softer and my skin feels smoother to the touch. The serum and creams feel downright luxurious, glide on like silk, and absorb fast without any greasy residue. I love that I can layer them and get on with my day. This is the first routine that’s made my skin look and feel refined again. Absolutely thrilled with the results.
Victoria Davids –
I’m a huge fan of Dr. Bryan and his work. This skincare system is unlike anything else on the market. Five stars!!
Polly –
I love how this skincare system has replaced my previously mis-matched routine. Instead of buying random “trendy” products that I see on social media, this is now my go-to. It’s such a simple routine that I am happy to use daily!
Annie Lo –
This is truly next level science and skincare. Who would have thought the benefits of nitric oxide could be seamlessly infused into a skincare products? So so smart. The clinical studies speak for themselves.
Rozzy Liu –
The age-defiance skincare system is cutting-edge science meets skincare. After months of using the nitric oxide serum, I decided to try the entire system—and I couldn’t be happier with the results. The difference it makes in how my skin feels is remarkable.
Nickey Renzo –
I recently turned 43 and realized my current skincare products just weren’t doing the job anymore. I wanted something with cleaner, more effective ingredients and I’ve been hearing a lot about dr. bryan and his work. this skincare system is not complicated and worth the splurge