The Science Of Age Defiance



The Science of Age-Defiance


Don’t just age with grace. Age better with advanced science.

Explore our range of products that are based on groundbreaking research into replenishing the Nitric Oxide (NO) that’s lost as we age.

Featured on The Human Upgrade with Dave Asprey

No Risk - 60-day Money Back Guarantee

Made in America

Nitric Oxide Products Backed by 20+ Years of Science

Our products are clinically proven to enhance Nitric Oxide in the body so that you feel the effects of aging less.

You loved us – too much!

We are currently sold out of our N1o1 Lozenges. We apologize for any inconvenience this has caused. We understand the importance of Nitric Oxide Lozenges to your health and daily routines. So you don’t miss a day, we can provide the same exact lozenge formula from our sister company, Bryan Nitriceuticals. We thank you for allowing us to be your trusted source of Nitric Oxide products! To your health!

Changing the Way We Age for the Better

We’re all going to age. It’s just a matter of how you’re going to do it. We believe in aging on your
own terms, and for us that means maintaining a high quality of health all around. One of the
common factors for making that happen is Nitric Oxide.

Properly formulated Nitric Oxide products have the ability to:

  • Improve Nitric Oxide production
  • Enhance the delivery of oxygen and nutrients to cells
  • Provide antioxidant support
  • Reduce wrinkles and fine lines
  • Correct dark spots and even skin tone
  • Improve skin texture and moisture
  • Increase elasticity
  • Create tighter, smoother skin
  • Repair damaged skin
  • Increase energy levels
  • Improve sexual function
  • Support cognitive function and memory
  • Support cardiovascular health
  • Promote normal heart function
  • Aid in healthy blood circulation and blood pressure
  • Create healthy blood flow to the brain and other organs

From the surface of your skin to the arteries underneath, Nitric Oxide is the factor that can make
aging better.


Backed by 20 Years of Scientific Research and Peer-Reviewed Published Clinical Studies. View the clinical studies click here.


A recently published study in the Journal of Surgery by Gregory Chernoff, M.D., F.R.C.S.(C) demonstrated the successful use of N1O1 a topical Nitric Oxide serum on aging skin, acne, wound healing, and scar therapy. View the study here. 


Dr. Bryan, CEO & Founder, has been a pioneering figure in the field of nitric oxide research for over 20 years. In addition to creating N1O1 by Pneuma Nitric Oxide, he is the holder of more than a dozen issued U.S. and International patents for breakthrough techniques that have revolutionized human physiology and disease management. The revolutionary N1O1 Nitric Oxide Activating Anti-Aging Serum is his next breakthrough patent.


N1o1 Anti-aging serum

the Aesthetic guide featuring n1o1 serum

“Early intervention with skincare keeps you looking younger, longer, sooner and often without expensive procedures.” – Dr. Chernoff


What Causes Clogged Pores?

What Causes Clogged Pores? Do you get breakouts that don’t ever seem to go away? Have you tried everything and for some reason you can’t get rid of a few blackheads or whiteheads? Clogged pores might be the reason your skin hasn’t been able to...

read more
Daily Beauty Habits That Are Aging Your Eyes

Daily Beauty Habits That Are Aging Your Eyes

Sometimes there just aren’t enough hours in the day—add in genetics, gravity, stress, and years of squinting and smiling, you get crow's feet, dark circles, and under-eye puffiness-factors that instantly add years to your appearance. But these aren’t the only things...

read more

What real n1o1 users are Saying...

[db_pb_slider arrows_custom_color="#333333" dot_nav_custom_color="#333333" _builder_version="4.20.4" _module_preset="default" background_color="RGBA(0,0,0,0)" custom_margin="0px||||false|false" custom_padding="56px||56px|0px|true|false" hover_enabled="0" box_shadow_style="preset2" global_colors_info="{}" module_class="remove-shortcode-error" sticky_enabled="0" _i="1" _address="" admin_label="db_pb_slider" /]

The N1o1 Money-Back Guarantee

There's nothing to lose, except Your wrinkles.

Developed and manufactured in the USA by Pneuma Nitric Oxide LLC.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat,
cure, or prevent any disease

© 2024 Pneuma Nitric Oxide LLC
Pneuma Nitric Oxide

Mailing Address

Pneuma Nitric Oxide, LLC

2407 S. Congress

Suite E 134

Austin, TX. 78704

Skip to content