N1o1 Nitric Oxide Lozenges
$53.98
Releases nitric oxide as the lozenge dissolves in your mouth.
Formulated by Dr. Nathan S. Bryan, PhD
N1o1 is designed to support your body’s declining nitric oxide production with science-backed nutritional, oral care, and skincare solutions, working from the inside out.
Meet the N1o1 lineup.
$53.98
Releases nitric oxide as the lozenge dissolves in your mouth.
$23.74
Breath of Life supports the mouth’s natural nitric oxide pathway without fluoride.
$55.98
Plant based, with fermented beetroot powder and patented PEAK ATP.
$95.98
A dual chamber formula that activates on contact, with Vitamin C and E.
$179.94
Buy three, get one free. Limited to one bundle per order.
Dr. Natalie Ledbetter, @drnatalieledbetter
Bauman Medical, @baumanmedical, on the serum for scalp care
@emiliavlogs on N.O. Beetz
Brianna Prather, medical aesthetician at @chernoffcosmeticsurgery, on the skincare system
@n1o1life
From food to circulation. Follow the nitric oxide pathway.
Leafy greens and beets provide dietary nitrate.
Bacteria on your tongue convert nitrate into nitrite.
Nitrite converts into nitric oxide in your tissues.
Nitric oxide signals blood vessel walls to relax.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Built for daily routines
Build nitric oxide support into the routines you already have.
Nitric oxide is a signalling molecule the body makes itself. Its best understood job is telling blood vessels to relax and widen.
Nitric oxide carries a message between cells. It tells the smooth muscle in vessel walls to relax.
The body's own nitric oxide production declines with age. That is the gap every product here is aimed at.
N1o1 offers dissolving lozenges and a beet powder drink. Healthy oral bacteria also play a role in the body’s natural nitrate-to-nitric-oxide pathway.
A lozenge that dissolves in the mouth, a toothpaste that protects the oral pathway, and topicals for skin.
Formulated by Dr. Nathan S. Bryan, PhD
N1o1 lozenges next to two common nitric oxide formats, compared on format, ingredients and pathway.

N1o1
Nitric Oxide Lozenges
Lozenge
Typical beet powder
Powder drink
Typical nitrate capsule
CapsuleComparison reflects common product types in each category, based on publicly available labels, November 2026. Formulas vary by brand; read the label on any product you take. Images in the other columns illustrate the format only.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
With over 30 years of nitric oxide research, Dr. Bryan personally formulates the N1o1 collection, science-backed nutritional supplements, oral care, and advanced skincare designed to support your body's nitric oxide system from the inside out.
The science, in his own words. Watch the full conversations.
The Diary of a CEO
The Human Upgrade
The Empowering Neurologist
Find your routine
Choose the routine you want to build. We will show you the clearest place to begin.
Recommended starting point
N1o1 lozenges release nitric oxide as they dissolve in the mouth. NO Beetz adds a fermented beetroot powder option.
N1o1 offers a 60-day money-back guarantee on all orders. The 60-day return window begins the day your order is received. Shipping charges for your original purchase are non-refundable. Please allow up to 30 days for returns to be processed. Read the Shipping and Returns Policy for exclusions and return instructions.
Nitric oxide is one of the most studied molecules in cardiovascular medicine, and one of the least understood outside it. Two places to begin.

Featured science
Most of the category sells precursors and hopes your body does the rest. Here is how the approaches differ and what to look for on a label.

Keep reading
Beet shots, powders and functional drinks all promise the same thing. A look at where the chemistry holds up.
Sales, bundle pricing and new product drops, a few times a month.
A signalling molecule the body produces itself. Its best understood role is telling the smooth muscle in blood vessel walls to relax, which widens the vessel.
Dr. Nathan S. Bryan, PhD, a nitric oxide researcher who has worked in the field for more than thirty years. He has authored or edited six books, two of which are carried in this catalog.
Most people start with the lozenges. It is the most reviewed product in the range.
No. It covers supplements, oral care and the Age-Defiance skincare line, plus bundles that group them.
Each bottle holds 60 lozenges. N1o1 recommends one lozenge twice a day, 12 hours apart, so one bottle is a 30-day supply. Follow the directions on your current bottle.
Because one stage of the pathway happens in your mouth. Bacteria on the back of the tongue perform a conversion the human body cannot do on its own, and antiseptic mouthwash disrupts them. The toothpaste is built to work with those bacteria rather than against them, which is also why it uses hydroxyapatite rather than fluoride.
The lozenge gives a sustained release and is the most reviewed product in the range. N.O. Beetz is a fermented beetroot powder you mix into water, it is oxalate-free, and it carries none of the usual beet taste or colour. Space the two at least four hours apart.
Check with your healthcare provider first. That is the honest answer rather than a reassuring one. If you have low blood pressure or take medication, have that conversation before you start.
Most people start with the lozenges, add the toothpaste to protect the oral step, and move into the Age-Defiance skincare if they want the same chemistry applied topically. Nothing requires anything else to work.