The N1O1 collection

MOISTURIZERFind your routine.

Unlock the secret to hydrated, glowing skin with Dr. Nathan S. Bryan's N1o1 moisturizers. Infused with potent nitric oxide, our moisturizers deliver deep hydration and enhance skin elasticity, leaving your complexion soft, smooth, and revitalized. Experience the luxury of advanced skin care designed for maximum moisture and radiance. Shop now to transform your skin care routine.

MOISTURIZER4 products

Age-Defiance Gel Cleanser

Skin Care

4.93 / 5 · 15 reviews from the migrated n1o1.com product reviews

Age-Defiance Gel Cleanser

A gel cleanser with alpha hydroxy acids, fruit extracts and hydrating ingredients. Use it as the first step before serum and moisturizer.

$31.98 Subscribe, save 20%

$39.98 one-time

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Nitric Oxide Activating Age-Defiance Serum

Skin Care

4.94 / 5 · 31 reviews from the migrated n1o1.com product reviews

Nitric Oxide Activating Age-Defiance Serum

The N1O1 dual-chamber serum keeps the two formulas separate until use. Mix them in your palm, then apply to the face and neck.

$95.98 Subscribe, save 20%

$119.98 one-time

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Nitric Oxide Boosting Age-Defiance Eye Cream

Skin Care

4.93 / 5 · 15 reviews from the migrated n1o1.com product reviews

Nitric Oxide Boosting Age-Defiance Eye Cream

An eye cream formulated with a peptide complex, ceramides and hydrating ingredients. Gently pat a small amount around the eyes as part of...

$47.98 Subscribe, save 20%

$59.98 one-time

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Nitric Oxide Age-Defiance Face Cream

Skin Care

4.85 / 5 · 13 reviews from the migrated n1o1.com product reviews

Nitric Oxide Age-Defiance Face Cream

A face cream with peptides, growth factors, humectants and nourishing lipids. Finish your morning and evening skincare routine with a moi...

$63.98 Subscribe, save 20%

$79.98 one-time

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Your skincare questions, answered

Find your skincare routine.

From the first cleanse to the final cream.

Where do I start?

Start with the step your routine needs. The collection includes a cleanser, serum, face cream, and eye cream.

Explore the cleanser
Age-Defiance Gel Cleanser Age-Defiance Gel Cleanser

Which step is the serum?

The serum is a separate step from cleansing and moisturizing. Its product page explains the ingredients and application directions so you can fit it into your existing routine.

Explore the serum
Nitric Oxide Activating Age-Defiance Serum Nitric Oxide Activating Age-Defiance Serum

Face cream or eye cream?

They are separate products for different areas. Compare their ingredients and follow each product’s application directions.

Explore face cream
Nitric Oxide Age-Defiance Face Cream Nitric Oxide Age-Defiance Face Cream

Can I focus on my eye area?

The eye cream has its own product page, ingredients, and directions. The Bright Eyes collection is another option to compare if you want a combination.

Explore eye cream
Nitric Oxide Boosting Age-Defiance Eye Cream Nitric Oxide Boosting Age-Defiance Eye Cream

Can I get the whole system?

The skincare system brings together several steps. Check its product page for the exact included products and instructions rather than assuming every skincare item is included.

See the skincare system
N1o1 Nitric Oxide Age-Defiance Skincare System N1o1 Nitric Oxide Age-Defiance Skincare System

How do I choose a bundle?

Compare what you already own with the contents of the bundle. Choose a combination that adds the steps you want, rather than duplicating products in your routine.

Explore Bright Eyes
N1o1 Nitric Oxide Age-Defiance Bright Eyes Collection N1o1 Nitric Oxide Age-Defiance Bright Eyes Collection

A place for every step.

Build around the products your routine actually needs.

Meet the formulator

Dr. Nathan S. Bryan.
The science behind N1O1.

Dr. Bryan formulates the N1O1 lineup himself. Hear the brand story, then explore the science and directions behind the products you choose.

Meet Dr. Bryan

Understand the steps before adding more.

A skincare routine is easier to understand when every product has a role. The N1O1 range separates cleansing, serum, face cream, and eye cream, so you can explore one step or a complete system.

Check the ingredient list and directions on each product page, especially when combining N1O1 with products you already use. Bundles are a way to buy products together; the individual application directions still matter.

A little more clarity

Your moisturizer questions,
answered.

What products are in the skincare collection?

The collection includes the N1O1 cleanser, serum, face cream, and eye cream.

Do I need the complete system?

You can shop individual products. Choose the steps you want to add and compare the system contents if you prefer a combination.

Where can I see the application order?

Open the product page for its application instructions. Follow those directions when building your routine.

Are face cream and eye cream interchangeable?

They are listed as separate products. Use each for the area and application described in its directions.

Where can I check the ingredients?

Each skincare product has its own ingredient information on its product page. Do not assume one formula represents the entire collection.

What if my skin is sensitive?

Review the ingredients and product directions before use. If you have a skin condition or a concern about your existing routine, ask your healthcare professional.

Still have a question?

Ask the N1O1 team

Find your next step.

Explore the range, read the details, and choose the routine that fits.

Back to the products