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CardioSmile Nitric Oxide Toothpaste Bundle (Bundle of 3)

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Boost your oral and systemic health with the world’s first nitric oxide-enhancing toothpaste for peak oral wellness. Free from fluoride and harmful toxins, it supports your mouth’s natural nitric oxide production. Developed by Dr. Nathan Bryan, Biomedical Scientist.

  • Boosts Your Mouth’s Natural Microbiome
  • Freshens Breath
  • Remineralizes Enamel
  • Fluoride-Free Formula
  • Enhances Gum Health

$74.97 — or subscribe to save 5%

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Healthier Gums. Brighter Smiles. More Confidence.

Your oral health thrives on strong circulation, healthy gums, optimal microbiome and optimal performance. But as you age, nitric oxide production declines—leading to weaker gum health, reduced blood flow, and less vibrant oral health.  Furthermore, the use of fluoride toothpastes, antiseptic mouthwashes lead to a loss of nitric oxide production. 

That’s why we created the CardioSmile Nitric Oxide Toothpaste—a revolutionary formula designed to boost nitric oxide levels, improve circulation, and support gum health, so you can enjoy a healthier smile every day.

Get Your Nitric Oxide Toothpaste

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  • Freshens Breath
  • Boost Nitric Oxide Production
  • Revitalize a Healthy Oral Microbiome
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“We have known for more than 100 years that poor oral hygiene leads to increased risk of cardiovascular disease. Today we know that the oral microbiome responsible for optimizing nitric oxide production accounts for the oral systemic link. Stringent antiseptics, fluoride and poor oral hygiene all disrupt the oral microbiome. Our nitric oxide focused line of oral care products supports the oral microbiome, improving nitric oxide production thereby improving oral and systemic health.”

—Dr. Nathan S. Bryan
International Expert in Nitric Oxide Biochemistry and Physiology

Oral Health

Dr. Nathan Bryan Talks Nitric Oxide on FOX & FRIENDS

Dr. Nathan Bryan joins FOX & FRIENDS to discuss the critical role of nitric oxide in overall health, energy, and longevity.

As a leading expert in the field, Dr. Bryan breaks down how this essential molecule supports circulation, heart health, brain function, and immune support—and why so many people may be unknowingly deficient.


How Nitric Oxide Impacts Your Oral Health

This fluoride-free toothpaste is thoughtfully crafted to support a healthy oral microbiome while boosting nitric oxide production, enhancing gum circulation, and promoting cardiovascular wellness. Its natural remineralizing properties strengthen enamel, offering protection against tooth decay. Perfect for those seeking a clean, fluoride-free alternative, it effectively controls tartar, reduces sensitivity, and supports both oral and overall health. With every use, it leaves your mouth feeling fresh, clean, and revitalized.  The only toothpaste targeting the nitric oxide microbiome.

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Freshens Breath Naturally

Nitric oxide helps prevent tooth decay by inhibiting the growth of cavity-causing bacteria.

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Boost Blood Flow & Circulation

Helps boost circulation for healthier gums and improved cardiovascular function.

N1O1 nitric oxide oral health and nitric oxide microbiome and nitric oxide production

Oral Microbiome Support

Formulated to nurture a healthy oral microbiome, fostering beneficial bacteria for optimal oral health.

N1O1 nitric oxide gum health and oral nitric oxide nitric oxide signaling molecule

Support Gum Health

Nitric oxide supports gum health by promoting blood flow and fighting off harmful bacteria.

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Reduce Plaque Build-up

Nitric oxide helps promote healthy saliva pH and production, which aids in neutralizing acids and reducing plaque buildup.

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Elevate Mood & Energy

Feel more vibrant and energized with the natural boost Nitric Oxide provides.

Support Your Oral Health Today

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Benefits

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Key Benefits May Support

  • Fluoride-Free Formula: Natural protection without fluoride.
  • Nitric Oxide Support: Enhances circulation for healthier gums and cardiovascular wellness.
  • Remineralizes Enamel: Hydroxyapatite strengthens and rebuilds tooth enamel for long-lasting protection.
  • Tartar Control: Zinc Citrate helps prevent plaque from hardening into tartar.
  • Oral Microbiome Support: Formulated to nurture a healthy oral microbiome, fostering beneficial bacteria for optimal oral health. 
  • Fights Sensitivity: Potassium Nitrate soothes nerves to reduce tooth sensitivity.
  • Freshens Breath Naturally: Peppermint, Spearmint, Wintergreen, and essential oils refresh your mouth while providing antimicrobial benefits.
  • Gentle Cleaning: Hydrated Silica and Calcium Carbonate gently polish teeth for a brighter smile.
  • No Harsh Chemicals: Formulated with natural, effective ingredients that are safe for you and the environment.
Get Your Nitric Oxide Toothpaste

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Directions

oral care products for health and wellness

Directions

Brush thoroughly, at least twice a day, or as directed by a healthcare provider.

Use desired amount on a toothbrush.

oral care products Dr. Nathan Bryan

Ingredients

Natural & Powerful ingredients
For Boosting Nitric Oxide and Supporting Oral Health

nitric oxide signaling molecule nitric oxide molecule

Nitric Oxide Support

This toothpaste enhances nitric oxide production, which supports blood flow to the gums, helping to promote healthy tissues and may help cardiovascular function. Nitric oxide also plays a vital role in reducing gum inflammation and improving overall oral health.

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Fluoride-Free Formula

Free from fluoride, this toothpaste provides natural protection using ingredients like Xylitol and Erythritol, which help reduce harmful bacteria while balancing the beneficial bacteria in your mouth. This supports a healthy oral microbiome and helps prevent cavities—without the use of fluoride.

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Tartar Control

Zinc Citrate actively prevents plaque from hardening into tartar, while Hydrated Silica and Calcium Carbonate gently polish teeth, removing surface stains and plaque to maintain a clean and smooth enamel surface.

N1O1 nitric oxide oral care products nitric oxide signaling molecule

Oral Microbiome Support

Ingredients such as Xylitol and Erythritol work to reduce harmful bacteria, promoting a balanced microbiome that supports oral health naturally.

N1O1 nitric oxide oral care products nitric oxide signaling molecule

Essential Oils

(Peppermint, Spearmint, Wintergreen, Tea Tree, Cinnamon)
These powerful essential oils provide antimicrobial benefits to fight plaque while freshening breath and soothing gums.

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Hydroxyapatite

This fluoride-free alternative helps rebuild and strengthen enamel, providing effective protection against decay while enhancing nitric oxide production to support gum health.

Full Ingredients List

FAQs

What is Nitric Oxide?
Nitric Oxide (NO) is a molecule that helps relax and widen blood vessels, improving circulation, oxygen delivery, and overall cardiovascular health. It also supports energy levels, endurance, cognitive, oral, and sexual function.

Nitric oxide plays a crucial role in maintaining good oral health. It helps to improve blood flow and supports the body’s natural defenses against harmful bacteria. Additionally, it aids in saliva production, which is essential for keeping the mouth clean and neutralizing acids that can erode tooth enamel. Without enough nitric oxide, these functions can become compromised, leading to various oral health problems.

Brush thoroughly, at least twice a day, or as directed by a healthcare provider. Use desired amount on a toothbrush.

Many users report an immediate clean mouth feeling with fresh breath.  Within a couple of days, an improvement in the oral microbiome and normal salivary pH.  Many people also report an increased energy and better circulation within days. However, consistent use over a few weeks yields the best long-term benefits.

Glycerin, Water, Sorbitol, Hydrated Silica, Calcium Carbonate, Potassium Nitrate, Xylitol, Hydroxyapatite Ψ Mentha Piperita (Peppermint) Oil, Xanthan Gum, Mentha Spicata (Spearmint) Leaf Oil, Gaultheria Procumbens (Wintergreen) Leaf Oil, Menthol, Cocos Nucifera (Coconut) Oil, Zinc Citrate, Citrus Aurantium Dulcis (Orange) Peel Oil, Citrus Limon (Lemon) Peel Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Cinnamomum Zeylanicum Bark Oil, Eucalyptus Globulus Leaf Oil, Thymus Vulvaris (Thyme) Flower/Leaf Oil, Erythritol, Cellulose Gum, Sodium Lauroyl Sarcosinate

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🚚 Fast Delivery within 2-6 business days

About Dr. Nathan Bryan

Dr. Nathan Bryan Dr. Nathan Bryan nitric oxide researcher

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

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A Pioneer in Nitric Oxide Science

With over 25 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

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Clinically Backed & Scientifically Proven

His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 Nitric Oxide Lozenges you’re about to experience.

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On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

Clinical Studies

[1] The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population: A Pilot Study
Annals of Plastic  & Reconstructive Surgery
Greg Chernoff* MD, FRCS(C)
Chernoff Plastic Surgery, Indianapolis, Indiana, Santa Rosa, California, US
Download the PDF

[2] The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients
International Journal of Pharmaceutica Analytica Acta
Greg Chernoff
Department of Otolaryngology, Head and Neck Surgery, St. Vincent Hospital, Indianapolis, Indiana, United States
Download the PDF

[3] The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing
Science Repository
Greg Chernoff
Ascension St. Vincent Hospital, USA
Download the PDF

[4] The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine
Gavin Publishers
Gregory Chernoff BSc, MD, FRCS(C)
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF

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