Debunking Nitric Oxide Myths
Another widespread claim in the supplement world is that L-arginine is nitric oxide. For decades, companies have promoted L-arginine powders and capsules as a way to improve circulation, boost nitric oxide, and support everything from workouts to sexual health.
It sounds logical at first, but it’s another nitric oxide myth that doesn’t hold up under closer look.
Why L-Arginine Looked Promising
Scientists have known for years that your body can make nitric oxide from an amino acid called L-arginine. That discovery sparked excitement in the supplement industry. If the body uses L-arginine to make nitric oxide, why not just take more of it?
That’s the theory. But the science, and the clinical results, don’t back it up.
The Problem With L-Arginine Supplements
Here’s what’s important to know:
- Your body already has plenty of L-arginine. It’s found in many protein-rich foods and produced naturally by your metabolism.
- Adding more L-arginine doesn’t guarantee more nitric oxide. The body tightly controls the process and requires multiple cofactors to make it happen.
- In people with health issues like high blood pressure, diabetes, or heart disease, the enzyme that converts L-arginine into nitric oxide often doesn’t work properly. That means no matter how much you take, it won’t fix the problem.

The Clinical Evidence
Several studies have tested L-arginine supplements, and the results have been disappointing, and in some cases, alarming.
One major trial looked at patients recovering from a heart attack. Those who took L-arginine had a higher death rate compared to patients taking a placebo. Because of this risk, researchers concluded that L-arginine should not be recommended after heart attacks.
Another study on people with peripheral artery disease found the same thing: no benefit, and in fact, worse outcomes for those who took L-arginine compared to placebo.
Why the Myth Continues
So why is L-arginine still being sold as a nitric oxide booster?
- It’s cheap to manufacture.
- The basic science about nitric oxide production sounds convincing.
- The marketing is powerful, even if the results don’t match.

Unfortunately, many supplement companies put profit before science, and L-arginine continues to be pushed despite the evidence.
The Takeaway on L-Arginine
L-arginine is not nitric oxide. While your body can use it in one of its pathways, supplementing with extra L-arginine doesn’t reliably increase nitric oxide levels, especially in people who need it most. Worse, some studies show it may even cause harm.
If you see nitric oxide products that include L-arginine or L-citrulline, that’s a red flag that the company doesn’t fully understand nitric oxide science.
Conclusion
I know how critical it is to protect the integrity of nitric oxide science. If misleading products dominate the market, consumers lose faith and the real solutions risk being overlooked. That’s why education is essential, once people understand how nitric oxide really works, they won’t fall for products that can’t deliver.
The reality is that supplements are not always reliable, and too many companies put profit ahead of people. Nitric oxide is not a substance you can bottle up. It’s a gas your body has to create. At N1o1, we’ve developed technology that does more than any capsule or beet powder ever could: it directly generates nitric oxide and helps restore your body’s natural production systems. It’s the only technology of its kind, and it works.