Research
[1] Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
PubMed
Nathan S Bryan, Gena Tribble, Nikola Angelov
Department of Molecular and Human Genetics, Baylor College of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Periodontics, The University of Texas Health Science Center at Houston, 7000 Fannin, Houston, TX, 77030, USA.
Read The Study
[2] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF
[3] Nathan S. Bryan, PhD, points out how using antiseptic mouthwash can reduce good oral bacteria and cause high blood pressure and other conditions.
Dental Sleep Practice
Nathan S Bryan
Read the Study
[4] Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
PubMed
Nathan S Bryan, John W Calvert, John W Elrod, Susheel Gundewar, Sang Yong Ji, David J Lefer
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
Download the PDF
[5] Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
PubMed
Allison E DeVan, Lawrence C Johnson, Forrest A Brooks, Trent D Evans, Jamie N Justice, Charmion Cruickshank-Quinn, Nichole Reisdorph, Nathan S Bryan, Matthew B McQueen, Jessica R Santos-Parker, Michel B Chonchol, Candace J Bassett, Amy L Sindler, Tony Giordano, Douglas R Seals
- Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
- Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
- Integrated Department of Immunology, National Jewish Health, Denver, Colorado
- Baylor College of Medicine, Houston, Texas
- Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado
- TheraVasc, Cleveland, Ohio
Download the PDF
[6] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile
- Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
- Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
- Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
- Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA
Download the PDF
Courtney P –
I recently started using the CardioSmile Nitric Oxide Toothpaste and WOW, it tastes amazing! I have been using another brand of toothpaste without flouride for the past 7 years, but was so excited to change to this one that has the extra benefits of increasing my nitric oxide production. Give it a try, you will love it!
B. McLaughlin –
The clean ingredients and fluoride-free formula while boosting your nitric oxide production makes this a standout product.
Amanda J. –
This is the ultimate upgrade to oral care. I love how it optimizes oral health while staying free of harmful chemicals.
Michael S. –
Not only does CardioSmile keep my mouth feeling fresh all day, but the focus on nitric oxide benefits is a total game-changer for my health!
Daniel H. –
Convenient, effective, refreshing AND good for my health! Couldn’t ask for more! Dr. Bryan is a genius—changing the dental industry!
Sophie C. –
Finally, a product that combines science and clean living! My mouth feels fantastic, and I love knowing it’s made with good ingredients.
J. Ahn –
Instant clean! Fresh and invigorating.
Christian P. –
CardioSmile tastes great and I highly recommend it! I’ve tried several other fluoride-free toothpaste brands and they don’t even come close. Dr. Bryan, hats off to you for this creation.
Catherine L. –
I love how this supports both my cardiovascular and oral health! What a revolutionary step in science!
KF (verified owner) –
I’ve been using the toothpaste for about a month. My teeth are very sensitive and I find less issues while using N1O1 toothpaste then sensodyne. My mouth feels fresher and I will be using this from now on. On top of the quality TP I get a nitric oxide boost .
David Johnson (verified owner) –
Honestly the best toothpaste I’ve tried in years. It tastes super fresh and I love knowing it’s actually helping my health too
Jeff Howarth (verified owner) –
I was skeptical at first, but this toothpaste feels so clean and natural. My mouth feels fresh all day without the chemical aftertaste.
Alan Grodon (verified owner) –
Finally found a toothpaste that’s good for me and doesn’t feel harsh. Love that it helps with nitric oxide too.
Melissa Pressler (verified owner) –
I’ve switched my whole family over to this. The flavor is great, and it just feels healthier than what we were using before
Larry Barron (verified owner) –
Never thought I’d notice a difference with toothpaste, but this one really does make me feel better overall. Definitely sticking with it.
CJ –
I do like all the benefits this toothpaste provides, but why so expensive? I use a product without fluoride that is half the cost and as someone on a fixed income, this double price is just too mush for me. A sample came with my last order, but won’t be buying until the price is more in keeping with my budget.
Allan –
I’ll admit, I was skeptical about switching from my regular toothpaste, but CardioSmile has completely transformed my oral care routine! As someone who drinks coffee daily and has always struggled with plaque buildup despite regular brushing, I was looking for something that could make a real difference.
After just two weeks of using CardioSmile, my dental hygienist commented on how much cleaner my teeth looked—and this was during my regular cleaning appointment! The plaque that used to accumulate so quickly has been dramatically reduced, and my teeth feel smooth and clean all day long.
What I love most is how fresh my breath stays throughout the day. I used to reach for mints after lunch, but now my mouth still feels clean and fresh hours after brushing. The fluoride-free formula was a huge selling point for me since I’ve been trying to reduce chemical exposure, and knowing that it’s actually supporting my oral microbiome while boosting nitric oxide production makes me feel great about my choice.
Lilian chung –
The taste is absolutely perfect—refreshing without being overwhelming, and it leaves my mouth feeling genuinely clean, not just masked with artificial flavors. This toothpaste has exceeded every expectation I had. Dr. Bryan has created something truly revolutionary for oral health!
Graclyn Parie –
I’ve struggled with sensitive teeth and gum irritation, trying everything from prescription toothpastes to expensive dental treatments. When my dentist mentioned that my gums were showing more signs of inflammation, I knew I needed to find a better solution. After a month of using cardiosmile, my tooth sensitivity decreased noticeably. My gums feel so much healthier and less tender, and I love that the clean, natural ingredients are actually supporting my mouth’s microbiome instead of disrupting it like harsh chemicals do
Jeff Abouaf (verified owner) –
I’ve been fluoride-free for years because I care about what goes in my body, but switching to CardioSmile Toothpaste has been a total win. It tastes incredible and the added nitric oxide support makes it feel like I’m doing something good for my health every time I brush. Highly recommend.
Mike Zapata (verified owner) –
Brushing my teeth is usually just another task to check off, but this toothpaste actually makes it enjoyable. The flavor is incredibly fresh, and I love knowing it’s providing me with extra health benefits beyond just cleaning my teeth. Finally, a toothpaste I actually look forward to using!
Fitness Junkie (verified owner) –
I’m all about performance and recovery, so finding a toothpaste that helps boost nitric oxide was a surprise. CardioSmile doesn’t just taste great, it ties right into my lifestyle. A simple swap that supports my workouts and my overall health — I’m hooked.
Amanda Klass (verified owner) –
Honestly, I thought all toothpaste was basically the same. But after trying CardioSmile, I get why people rave about it. The taste is awesome, my mouth feels cleaner than ever, and the idea of boosting nitric oxide while brushing? Pretty amazing.
Vincent –
I switched to CardioSmile right shortly after a dental checkup. I have used it consistently since then. I had a dental checkup last week. The dentist was very pleased with what he found. My teeth and my gums are in fantastic shape. Best dental checkup I’ve had in a long time. It tastes good tood.
Matthew –
After using this product since launch my gums feel healthier and my stays fresh. I specifically love that it’s fluoride free. It’s nice knowing my toothpaste is doing more than just cleaning my teeth. Highly recommend!
Derrick R –
Hands down the best toothpaste I’ve ever used. My smile looks better than it has in years and my mouth just feels cleaner & healthier. I will be recommending this to my dentist the next time I see him!
Sam B. (verified owner) –
Love that it has heart health boosting benefits in addition to oral health. Wish is was mintier
lydia p. (verified owner) –
Great formula and I’m a huge fan of Dr. Bryan’s work on nitric oxide. The toothpaste tub is kinda hard to squeeze out especially when you get to the bottom.
Kim (verified owner) –
At 70 years old they R making a difference thank U
Kim (verified owner) –
It’s really making a difference thank U regards kim
Carolyn Page (verified owner) –
Could not be happier. Dr Bryan, you deserve every accolade you receive. This is a total game changer. Fresh breath, clean mouth, and overall health support is becoming obvious with every brush. Thank you so much.
Jeff R. (verified owner) –
I am very thankful for Dr. Nathan Bryan’s 30 years of research on Nitric Oxide. I use the toothpaste and also use the nitric oxide tablets and am seeing results from both. I had no idea how important N.O. is until I found out from Dr. Bryan’s podcasts. Low levels of N.O. can affect blood pressure and A1C and me being a mouth breather isnt good either since mouth breathing doesnt naturally produce nitric oxide. Thanks for the creation of these products and I will keep using them.
Jeff R.
Shane Bruno (verified owner) –
Science-backed and effective — this is the future of toothpaste!
matt nichol (verified owner) –
Fresh breath + stronger teeth + nitric oxide boost 🔥
jarret finley (verified owner) –
The detail and research behind this is amazing! Love how Dr. Bryan always brings science and health together
zoe cruise (verified owner) –
Cardiosmile is literally changing the game for oral health!!!
JA –
I’ve been using Cardio Smile toothpaste for a while now, and I absolutely love it! It leaves my mouth feeling incredibly fresh and clean without that harsh, artificial aftertaste some toothpastes have. I really appreciate that it’s fluoride-free and made with clean ingredients, which gives me peace of mind about what I’m putting in my body every day. My teeth feel smooth, my gums feel healthy, and I actually look forward to brushing. Highly recommend this toothpaste to anyone looking for a natural, effective option that truly works!
V Newhoff –
I received my order of Cardiosmile and a few weeks before I was referred to an oral surgeon. I had to get a tooth removed and afterwards, I was given antibiotics. A few days after I started the antibiotics, I noticed my tongue was completely turning white. I decided not to finish my old toothpaste and I started brushing with Cardiosmile and within two days my tongue returned to its normal status. This is definitely my toothpaste.