Nitric Oxide Oral Wellness Duo

Did you know that the secret to a healthy heart might actually live in your mouth?

For decades, we’ve treated oral care and heart health as separate disciplines. You see a dentist for your teeth and a cardiologist for your heart. However, groundbreaking science has revealed a critical “oral-systemic link.” Your mouth is not just a tool for eating and speaking; it is the gateway to your overall cardiovascular wellness.

At the center of this connection is a foundational molecule called nitric oxide.

As we age, our body’s ability to produce nitric oxide declines by over 50% by the age of 40, leading to reduced circulation, lower energy, and weaker heart health. While the body produces this molecule naturally, it relies heavily on a healthy oral microbiome to do so. Unfortunately, harsh antiseptic mouthwashes and fluoride toothpastes often destroy the beneficial bacteria needed for this process.

To address this, nitric oxide leader, Dr. Nathan S. Bryan, developed a revolutionary two-step system to restore this vital connection: CardioSmile Nitric Oxide Boosting Toothpaste and N1o1 Nitric Oxide Lozenges. Together, they cleanse, prime, and replenish your body to support optimal oral health and cardiovascular function.

The Science: How Your Mouth Powers Your Heart

The oral microbiome—the community of bacteria living in your mouth—is responsible for the first step in nitric oxide production. When this microbiome is disrupted by harsh chemicals or poor hygiene, your nitric oxide levels plummet.

Nitric oxide is the master signaling molecule in the cardiovascular system. It signals your blood vessels to relax and widen, allowing for:

Healthy blood pressure regulation
Improved oxygen delivery to organs
Enhanced athletic performance and recovery
Better cognitive function

By nurturing your oral microbiome rather than sterilizing it, you create the optimal environment for heart health to flourish.

Additional information

Weight	8 oz

How To Use

Step 1: Prime the Microbiome

CardioSmile Nitric Oxide Boosting Toothpaste

Most toothpastes are designed to sterilize. CardioSmile is designed to revitalize.

This is the world’s first nitric oxide-enhancing toothpaste. Unlike conventional products that strip your mouth of its natural defenses, CardioSmile is a fluoride-free formula crafted to support a healthy oral microbiome. It prepares the “soil” of your mouth, encouraging the growth of beneficial bacteria that convert dietary nitrates into nitric oxide.

Key Benefits May Support:

Oral Microbiome Support: Nurtures the beneficial bacteria essential for nitric oxide production.
Enhanced Gum Health: Improves micro-circulation in the gums to fight inflammation and bleeding.
Enamel Remineralization: Features Hydroxyapatite, a natural alternative to fluoride that rebuilds and strengthens tooth enamel.
Tartar Control: Zinc Citrate prevents plaque from hardening into tartar without harsh abrasion.
Natural Freshness: A blend of essential oils (Peppermint, Spearmint, Wintergreen) freshens breath while providing gentle antimicrobial benefits.

Step 2: Restore Systemic Levels

N1o1 Nitric Oxide Lozenges

Once you have primed your oral environment, the next step is to directly replenish your body’s nitric oxide levels.

N1o1 Nitric Oxide Lozenges are scientifically formulated to release nitric oxide gas as they dissolve in your mouth. This unique delivery system bypasses the digestive tract, allowing the molecule to be absorbed directly into the bloodstream through the oral mucosa. This mimics the body’s natural production mechanism, delivering immediate benefits to your circulation and energy levels.

Key Benefits May Support:

Circulatory Boost: Rapidly dilates blood vessels to improve flow throughout the entire body.
Heart Health Support: Helps maintain healthy blood pressure levels already within the normal range.
Cognitive Function: Increases blood flow to the brain, supporting focus and mental clarity.
Energy & Vitality: Enhances oxygen and nutrient delivery to muscles, reducing fatigue and boosting stamina.

The Combined Power of the N1o1 System

Using these products together creates a synergistic effect that addresses both the cause of nitric oxide decline (a disrupted microbiome) and the symptom (low systemic levels).

Your Daily Heart-Health Routine

Brush (Morning & Night): Use CardioSmile Toothpaste to clean teeth, remineralize enamel, and establish a nitrate-reducing microbiome.
Dissolve (Twice Daily): Place one N1o1 Nitric Oxide Lozenge in your mouth. Move it around slowly above your tongue as it dissolves (about 5-6 minutes). This floods your system with nitric oxide.

- Pro Tip: For best results, take one lozenge, twice daily 12 hours apart to maintain steady nitric oxide levels all day. Hydrate before use.
- If you’re finding sensitivity, alkalize your mouth with a baking soda and water mixture prior to taking the lozenge.

Watch & Learn

Discover how to maximize your daily nitric oxide routine for better circulation, heart health, and oral microbiome support. Learn how these two products work together to support healthy blood flow, cardiovascular function, energy, and overall wellness — starting in your mouth.

Dr. Nathan Bryan,
Founder of N1o1 Nitric Oxide

Ingredients

Clean, Clinical Ingredients

We believe in ingredients that work with your body, not against it.

CardioSmile Toothpaste

Highlights

Hydroxyapatite: For enamel strength.
Zinc Citrate: For plaque control.
Xylitol & Erythritol: To reduce harmful bacteria while sparing the good ones.
Botanical Blend: Peppermint, Tea Tree, Cinnamon, and Wintergreen oils.
No Fluoride, No Sulfates, No Harsh Antiseptics.

Nitric Oxide Lozenge

Highlights

Vitamin C (Magnesium Ascorbate): 164mg for antioxidant support.
Magnesium: Supports muscle function and reduces fatigue.
N1o1 Proprietary Blend: A specialized mix including Sodium Nitrite designed to generate nitric oxide gas upon dissolution.
Gluten-Free, Vegan, Non-GMO.

FAQs

Why shouldn't I just use regular mouthwash?

Most antiseptic mouthwashes kill 99.9% of bacteria indiscriminately. This includes the “good” bacteria your body relies on to produce nitric oxide. Using them can actually increase your blood pressure by shutting down this natural pathway. CardioSmile is formulated to clean without disrupting this delicate balance.

Are the toothpaste and lozenges safe for daily use?

Yes! Both CardioSmile Toothpaste and N1o1 Lozenges are formulated for daily usage, using safe, non-toxic, and clinically backed ingredients. They are vegan, gluten-free, and free of harsh chemicals and artificial additives.

Can I use these products together?

Absolutely. CardioSmile Toothpaste and N1o1 Nitric Oxide Lozenges are designed to be used as a system. Using both together amplifies the benefits for oral microbiome support and nitric oxide production, supporting both oral and systemic health.

When will I start to notice results?

Many users notice fresher breath and a cleaner mouth right away. Benefits like improved gum health, reduced sensitivity, and better energy or blood pressure typically become noticeable within a few days to a few weeks of consistent use.

Do these products replace my regular toothpaste and supplements?

Yes, you can use CardioSmile Toothpaste in place of your traditional toothpaste. N1o1 Nitric Oxide Lozenges are unique and can complement your supplement routine, focusing specifically on nitric oxide and circulatory wellness.

Can children use these products?

CardioSmile Toothpaste is safe and suitable for anyone including children. N1o1 Nitric Oxide Lozenges are formulated for adults; check with a healthcare provider for guidance for minors.

Are there any side effects?

Both products are generally well tolerated. On occasion, those with very sensitive mouths may experience mild irritation from the lozenges, which can usually be resolved by alkalizing the mouth before use (e.g., rinsing with baking soda water).

What makes these products different from others?

Unlike conventional oral care products that may harm your oral microbiome, our system prioritizes beneficial bacteria, stimulates nitric oxide naturally, and leverages the latest scientific research linking oral and cardiovascular health.

How quickly do the lozenges work?

Physiological effects begin within seconds. As the lozenge dissolves, carotid arteries begin to dilate, increasing blood flow to the brain and body within minutes. Long-term benefits to the oral microbiome and arterial health compound with consistent use over weeks and months.

Can I use the toothpaste if I have sensitive teeth?

Yes. CardioSmile contains Potassium Nitrate, a compound clinically proven to soothe nerves and reduce tooth sensitivity, along with Hydroxyapatite to strengthen the enamel barrier.

Take control of your health right where it starts.
By switching to a nitric oxide-focused oral care routine, you aren’t just getting a brighter smile—you are investing in better circulation, sustained energy, and a healthier heart.

Dr. Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

Clinical Studies

[1] Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria
PubMed
Sandesh C S Nagamani, Philippe M Campeau, Oleg A Shchelochkov, Muralidhar H Premkumar, Kilian Guse, Nicola Brunetti-Pierri, Yuqing Chen, Qin Sun, Yaoping Tang, Donna Palmer, Anilkumar K Reddy, Li Li, Timothy C Slesnick, Daniel I Feig, Susan Caudle, David Harrison, Leonardo Salviati, Juan C Marini, Nathan S Bryan, Ayelet Erez, Brendan Lee
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Download the PDF

[2] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF

[3] Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease
PubMed
Nathan S Bryan
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek Building for Biomedical Research R-850, Houston, TX, 77030, USA.
Read the Study

[4] Nitric oxide enhancement strategies
PubMed
Nathan S Bryan
Department of Molecular & Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Private Practice, Chernoff Cosmetic Surgeons, Ascension St. Vincent Hospital, Indianapolis IN, USA
Download the PDF

[5] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA
Download the PDF

[6] Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
PubMed
Nathan S Bryan, Gena Tribble, Nikola Angelov
Department of Molecular and Human Genetics, Baylor College of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Periodontics, The University of Texas Health Science Center at Houston, 7000 Fannin, Houston, TX, 77030, USA.
Read The Study

[7] Nathan S. Bryan, PhD, points out how using antiseptic mouthwash can reduce good oral bacteria and cause high blood pressure and other conditions.
Dental Sleep Practice
Nathan S Bryan
Read the Study

[8] Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
PubMed
Nathan S Bryan, John W Calvert, John W Elrod, Susheel Gundewar, Sang Yong Ji, David J Lefer
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
Download the PDF

[9] Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
PubMed
Allison E DeVan, Lawrence C Johnson, Forrest A Brooks, Trent D Evans, Jamie N Justice, Charmion Cruickshank-Quinn, Nichole Reisdorph, Nathan S Bryan, Matthew B McQueen, Jessica R Santos-Parker, Michel B Chonchol, Candace J Bassett, Amy L Sindler, Tony Giordano, Douglas R Seals

Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
Integrated Department of Immunology, National Jewish Health, Denver, Colorado
Baylor College of Medicine, Houston, Texas
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado
TheraVasc, Cleveland, Ohio

Download the PDF

[10] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile

Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

Download the PDF

4 reviews for Nitric Oxide Oral Wellness Duo

Rated 5 out of 5

Daniel H. – 03/09/2026

“Changing the Dental Industry”
Convenient, effective, refreshing AND good for my health! Couldn’t ask for more! Dr. Bryan is a genius —changing the dental industry!
Rated 5 out of 5

Michael D. – 03/09/2026

“Immediate Impact”
I’ve been trying to lower my blood pressure naturally… 24h after starting this product I saw a drop. It really works.
Rated 5 out of 5

Allan – 03/09/2026

“Oral Health Transformation”
After just two weeks… my dental hygienist commented on how much cleaner my teeth looked. The plaque that used to accumulate so quickly has been dramatically reduced.
Vincent – 04/01/2026

I’ve been using N1o1 products for about a year, and the products in the Oral Wellness Bundle have been a great.

The Cardio Smile toothpaste is easy to use and supports nitric oxide production while helping to keep good oral health. I switched from a traditional fluoride toothpaste with some hesitation—but after two six-month dental checkups, my dentist confirmed everything looks great. No cavities, no issues.

The lozenges have been just as impressive. I started taking one before bed, and the difference has been noticeable. I fall asleep faster, sleep more deeply, and wake up feeling refreshed—something I’ve struggled with for years.

Simple to use. Real results. Highly recommend.

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Boost Heart Health and Oral Wellness

N1o1 Nitric Oxide Lozenges

Enhance Circulation, Vitality, and Overall Wellness

CardioSmile Nitric Oxide Boosting Toothpaste

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The Science: How Your Mouth Powers Your Heart

Additional information