Scientific Breakthrough in Nitric Oxide Delivery
DALLAS, TX – June 12, 2023 – N1o1 announced the launch of a groundbreaking nitric oxide supplement that represents a major advancement in vasodilation technology. This orally disintegrating tablet generates nitric oxide directly in the mouth, bypassing traditional enzymatic pathways and delivering measurable improvements in blood flow, cardiovascular markers, and sexual health.
Developed by world-renowned nitric oxide researcher Dr. Nathan S. Bryan, this innovation is the result of over 25 years of scientific research. It addresses the shortcomings of conventional supplements like L-arginine, which often fail in aging adults or those with poor vascular health. Learn more about Dr. Bryan’s work.
“Most nitric oxide products depend on your body working perfectly. Ours doesn’t,” says Dr. Bryan. “That’s what makes N1o1 revolutionary—it works because your body doesn’t have to.”
Why This Delivery System Works
Traditional NO supplements struggle with three major issues: age-related enzyme decline, poor bioavailability, and breakdown in the digestive tract. N1o1 overcomes these problems with an enzyme-independent system that creates nitric oxide directly in the oral cavity.
The lozenge initiates a redox reaction with saliva, using carefully formulated nitrite and reductant ingredients to convert nitrite into nitric oxide. This mimics the body’s natural NO production without relying on enzymes or oral bacteria. See lozenge details.
Within seconds, NO is released and absorbed through the oral mucosa into systemic circulation, creating immediate vasodilation. This results in consistent, predictable effects across all age groups and health conditions.
Clinical Evidence of Effectiveness
Human trials have confirmed N1o1’s superior performance compared to traditional vasodilators. Participants using N1o1 experienced faster, more measurable increases in salivary and exhaled NO than those using L-arginine-based supplements. See the PubMed research.
N1o1 users also showed improved endothelial function, reduced blood pressure, and better microcirculation. These benefits were especially pronounced in older adults or those with vascular impairment.
Who Benefits Most
- Men over 40 with erectile dysfunction
- Women over 45 seeking firmer, healthier skin
- Athletes aiming to enhance stamina and recovery
- Individuals with poor circulation or high blood pressure
- Anyone nitric oxide-deficient due to diet, stress, or inactivity
Proven Safe and Effective
It took over eight years of research and trials to develop N1o1’s formula. The product has been tested in multiple IRB-approved human studies, showing no significant adverse events even with long-term use.
The ingredients are GRAS and free of metals, preservatives, synthetics, or allergens. The product is manufactured in a GMP-certified U.S. facility with rigorous testing and third-party validation.
How N1o1 Compares to L-Arginine
L-arginine relies on an enzyme system that weakens with age and requires a healthy endothelium. It also competes for absorption in the gut. In contrast, N1o1 works non-enzymatically in the mouth, delivering nitric oxide directly and quickly—within seconds.
Dr. Bryan says, “L-arginine is like giving a car gas with a broken engine. N1o1 is the repair and the fuel—delivering what your body no longer makes efficiently.” Watch Dr. Bryan’s interview.
What Users Report
Many users feel a warm sensation or increased alertness within minutes. By day three, many report better blood flow and energy. After two weeks, sustained improvements in performance, stamina, and cardiovascular health are common.
One user said, “By day three, I noticed better circulation. By week two, I felt ten years younger.” Another shared, “I tried L-arginine and other ED products. Nothing worked until I tried N1o1.”
Market Impact and What’s Ahead
N1o1 is reshaping expectations in nitric oxide supplementation. By avoiding the limitations of precursors and delivering measurable NO directly, it’s poised to disrupt the market.
The company plans to expand into cognitive support, immunity, metabolism, and skincare. They’re also developing diagnostic tools to help users track real-time NO levels and plan to enter international markets soon.
“Our mission is to make nitric oxide optimization accessible, measurable, and effective for everyone,” says Dr. Bryan. See ongoing research.
About N1o1
N1o1 is a science-first health tech company focused on delivering nitric oxide through innovative systems. Founded on the work of Dr. Nathan S. Bryan, one of the top experts in NO biology, N1o1 creates products that improve vascular health, performance, and wellness.
Media Contact
Alan Morell
amorell@creativemanagementpartners.com
9440 Santa Monica Blvd. Suite 301, Beverly Hills, CA 90210
Direct: 508-292-7900
Additional Resources
- N1o1 Lozenges
- About Dr. Bryan
- Cardiovascular Benefits of NO
- Amazon Listing
- YouTube Interview
- Dr. Bryan on LinkedIn
