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Defy Aging

Get Youthful Skin with N.O.

The Science of N1O1 – A Nobel Prize Winning Discovery

Nitric Oxide Depletion Is Responsible For Accelerated Aging Skin!

Starting in your 20’s, your body slowly loses the ability to produce the anti-aging molecule—nitric oxide. By age 40, your body loses 50% of the nitric oxide it needs to function at peak efficiency. As a result, skin cells become dysfunctional, your skin ages, and wrinkles appear.

N1O1 replaces the age-related loss of nitric oxide to repair wrinkled or damaged skin and restore a youthful appearance.

What Is Nitric Oxide?

Nitric oxide (NO) is known as the anti-aging molecule and is one of the essential molecules naturally produced in humans. This simple molecule regulates cellular communication by aiding oxygen and nutrient delivery to every cell in the body. When you don’t produce enough nitric oxide, your cells can’t maintain optimal health and start to malfunction.

How Nitric Oxide Loss Affects Your Skin

Cells malfunction or age when they do not get enough oxygen and nutrients. Skin cells are no different. Healthy cells are hydrated and have sufficient collagen. However, unhealthy cells lose collagen and hydration, creating fine lines and wrinkles on the skin. Nitric oxide helps the body provide nutrients and oxygen so the skin cells can restore their function. This includes collagen deposition, improved hydration, the loss of fine lines and wrinkles, and improved skin tone, quality, and texture.

Why Pneuma Nitric Oxide?

Healthy skin cells are like little buckets filled with nutrients, oxygen, and water. Keeping the tone, quality, and texture of your skin makes you appear youthful and healthy. As you age, your body loses its ability to produce enough nitric oxide. Your little buckets spring holes allowing the nutrients and moisture to leak from the cells. Other anti-aging skincare products try to keep filling a leaky bucket. But without fixing the holes, they can never keep up even with continuous use. You have to use more or more vital anti-aging skincare or resort to injections, fillers, and surgery. N1O1 works by fixing the holes in your buckets so that skin cells can retain their vital nutrients, moisture, and collagen production. N1O1 essentially reverses the effects of the aging process to visibly reduce wrinkles and improve the tone, quality, texture, and clarity of your skin.

Woman's Face

Ten Facts about Nitric Oxide (NO)

  1. Nitric oxide is one of the most important molecules produced in the human body.
  2. NO is a potent vasodilator that keeps your arteries open and blood flowing to every cell in your body.
  3. Nitric oxide is made by every cell in your body; however, production declined by 10-12% per decade starting in the early 20s. By age 40-50, we make only 50%.
  4. Loss of NO production is associated with the normal aging process.
  5. Prescription drugs, such as proton pump inhibitors, NSAIDS, antibiotics, antiseptic mouthwash, and cholesterol-lowering statin drugs block the production of NO.
  6. Most people do not know what nitric oxide is or why it is critical that they employ strategies to restore nitric oxide.
  7. NO has been shown to dilate blood vessels and recruit new blood vessels, improving circulation to regions as it is produced or supplied.
  8. NO has potent anti-inflammatory properties that help combat free radicals that damage cells and cause premature aging.
  9. NO is responsible for cellular energy production and cell metabolism that keeps cells healthy and functional.
  10. Due to diet, lifestyle, and many drug therapies, most Americans are deficient in nitric oxide.
Girl Doing Her Facial Skin Care
 elderly woman with gray hair

Flawless Skin

Get Radiant Skin

Nitric oxide repairs wrinkled and damaged skin by reversing cell aging. Give your skin the love it deserves with the N1O1 Serum by Pneuma Nitric Oxide.


Nitric Oxide Discoveries Win Nobel Prize

Nitric Oxide is so important, it was named “Molecule of the Year” by Science Magazine in 1992 and in 1998, a Nobel Prize in Physiology or Medicine was awarded to the three US scientists responsible for its discovery.

The Nobel Prize in Physiology & Medicine 1998 “For… discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system”


GROUNDBREAKING SKINCARE Backed by 20 Years of Scientific Research and Peer-Reviewed Published Clinical Studies.

Clinical Wound Healing Study Published in Surgical Case Reports doi: 10.31487/j.SCR.2020.09.04. Volume 3(9): 2-4. “The Utilization of a Nitric Oxide Generating Serum for Improving Vascularity in Wound Healing.”
Clinical Aesthetic Medicine Study Published in J Surg 5: 1329. DOI: 10.29011 2575-9760.001329. “The Utilization of a Topical Nitric Oxide Generating Serum in Aesthetic Medicine.”

Clinical Aging Skin Study Published in the Annals of Plastic and Reconstructive Surgery “The Utilization of a Topical Nitric Oxide Generating Serum in the Aging Skin Population”
Clinical Active Acne Study Published in the International Journal of Pharmaceutica Analytica Acta “The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne Scarred Patients”

 elderly woman with gray hair

‘‘The discovery of nitric oxide and its function is one of the most important in the history of cardiovascular medicine.

Valentine Fuster, M.D. 1998 President of the American Heart Association Head of Cardiology at Mount Sinai Hospital in Manhattan

Lab testing confirms incredible results.

Creating Nitric Oxide on the Surface of the Skin With N1o1

Infrared thermography can be used to detect changes in radiation. The amount of radiation emitted by an object increases with temperature. Therefore, thermography allows one to see variations in temperature. 

The image above is the thermogram of same person 4 minutes after application of Pneuma Nitric Oxide Skin Serum to face, next and chest. The increase in nitric oxide production is apparent.

4-Minute Progression After Application

Nitric Oxide (NO) is considered one of the most important molecules naturally produced in humans. This simple molecule controls oxygen and nutrient delivery to every cell in the body, it regulated cellular communication. All of which affects the signs of aging. In fact, this molecule is so important it was named “Molecule of the Year” by Science Magazine in 1992 and in 1998 a Nobel Prize in Physiology or Medicine was awarded to the three US scientists responsible for its discovery. Loss of nitric oxide production is part of the normal aging process.


Berkowitz, D.E., et al., Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation, 2003. 108(16): p. 2000-6. Taddei, S., et al., Age-related reduction of NO availability and oxidative stress in humans. Hypertension, 2001. 38(2): p. 274-9. Egashira, K., et al., Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation, 1993. 88(1): p. 77-81. Gerhard, M., et al., Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension, 1996. 27(4): p. 849-53. Lundberg, J.O., et al., Nitrate, bacteria and human health. Nat Rev Microbiol, 2004. 2(7): p. 593-602. Hord, N.G., Y. Tang, and N.S. Bryan, Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr, 2009. 90(1): p. 1-10. Kapil, V., et al., Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension, 2010. 56(2): p. 274-81. Kapil, V., et al., Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med, 2013. 55: p. 93-100. Bryan, N.S., et al., Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol, 2005. 1(5): p. 290-7. Bryan, N.S. and J.L. Ivy, Inorganic nitrite and nitrate: evidence to support consideration as dietary nutrients. Nutr Res, 2015. 35(8): p. 643-54. Bryan, N.S., K. Bian, and F. Murad, Discovery of the nitric oxide signaling pathway and targets for drug development. Front Biosci, 2009. 14: p. 1-18.

Nitric oxide production in the skin is a normal process that declines with age 1,2.

  1. Nitric Oxide. 2004 Jun;10(4):179-93.
  2. Hypertension, 2001. 38(2): p. 274-9

Indeed, loss of production of nitric oxide leads to advanced aging and the appearance of fine lines and wrinkles along with poor complexion and tone of the skin.


The N1o1 Money-Back Guarantee

There's nothing to lose, except Your wrinkles.

Pneuma Nitric Oxide

Mailing Address

Pneuma Nitric Oxide, LLC

2407 S. Congress

Suite E 134

Austin, TX. 78704


(877) 476-3862


Developed and manufactured in the USA by Pneuma Nitric Oxide LLC.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat,
cure, or prevent any disease

© 2023 Pneuma Nitric Oxide LLC
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